Lifeboat Foundation

Researchers have significantly improved gene-editing techniques. This new method, called eePASSIGE, can insert or replace entire genes in human cells with much higher efficiency than previous methods. This advancement could lead to a single gene therapy for diseases caused by various mutations in a single gene, like cystic fibrosis. Traditionally, gene therapy required a different treatment for each mutation.

EePASSIGE combines prime editing, which edits small stretches of DNA, with new enzymes that insert large pieces of DNA. This allows scientists to introduce a healthy copy of a gene directly where it belongs in the genome.

“This is one of the first examples of targeted gene integration with potential for therapeutic applications,” said Dr. David Liu, senior author of the study. “If these efficiencies translate to patients, many genetic diseases could be treated.”

David is one of the world’s best-known philosophers of mind and thought leaders on consciousness. I was a freshman at the University of Toronto when I first read some of his work. Since then, Chalmers has been one of the few philosophers (together with Nick Bostrom) who has written and spoken publicly about the Matrix simulation argument and the technological singularity. (See, for example, David’s presentation at the 2009 Singularity Summit or read his The Singularity: A Philosophical Analysis)

During our conversation with David, we discuss topics such as: how and why Chalmers got interested in philosophy; and his search to answer what he considers to be some of the biggest questions – issues such as the nature of reality, consciousness, and artificial intelligence; the fact that academia in general and philosophy, in particular, doesn’t seem to engage technology; our chances of surviving the technological singularity; the importance of Watson, the Turing Test and other benchmarks on the way to the singularity; consciousness, recursive self-improvement, and artificial intelligence; the ever-shrinking of the domain of solely human expertise; mind uploading and what he calls the hard problem of consciousness; the usefulness of philosophy and ethics; religion, immortality, and life-extension; reverse engineering long-dead people such as Ray Kurzweil’s father.

As always you can listen to or download the audio file above or scroll down and watch the video interview in full. To show your support you can write a review on iTunes, make a direct donation, or become a patron on Patreon.

Researchers from Tel Aviv University (TAU) have created a new type of glass with unique and even contradictory properties, such as being a strong adhesive (sticky) and incredibly transparent at the same time. The glass, which forms spontaneously when comes in contact with water at room temperature, could bring about a revolution in an array of different and diverse industries such as optics and electro-optics, satellite communication, remote sensing and biomedicine.

The glass was discovered by a team of researchers from Israel and the world, led by PhD student Gal Finkelstein-Zuta and Prof. Ehud Gazit from the Shmunis School of Biomedicine and Cancer Research at the Faculty of Life Sciences and the Department of Materials Science and Engineering at the Faculty of Engineering at TAU. The results of the research were recently published in the prestigious scientific journal Nature.

Find out how the recent discovery of a bacterial molecular oddity known as bridge RNA, has led to the creation of a novel gene editing tool.

A new gene editing technique derived from bacterial “jumping genes” can add, remove, recombine and invert DNA sequences, potentially overcoming some of the limitations of CRISPR.

The approach is made possible by a molecule called bridge RNA, the discovery of which came about through a joint effort led by scientists at the Arc Institute in Palo Alto, California, in collaboration with the University of Tokyo. They described their work in a pair of papers published June 26 in Nature.

Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind. But a team led by Penn State researchers has found a way to reprogram disease evolution and design tumors that are easier to treat.

They created a modular genetic circuit that turns cancer cells into a “Trojan horse,” causing them to self-destruct and kill nearby drug-resistant cancer cells. Tested in human cell lines and in mice as proof of concept, the circuit outsmarted a wide range of resistance.

The findings were published today, July 4, in the journal Nature Biotechnology. The researchers also filed a provisional application to patent the technology described in the paper.

Bioengineers demonstrated that an ATP biosensor can be used to reveal microbial energetic dynamics and facilitate bioproduction.

Aussie scientists have developed a new gene-editing technique that could be a major breakthrough. It could allow scientists to make accurate and more significant changes to DNA.

#Science #GeneEditing #genes

Giorgia Marucci of HORIBA explains how Jennifer Doudna, Emmanuelle Charpentier and their research teams revolutionized genetic engineering with their CRISPR-Cas9 discovery. Their groundbreaking approach to DNA editing elevated these two scientists to Nobel Laureate status when they received the Nobel Prize in Chemistry in 2020.

Read more about this story at: https://www.horiba.com/int/scientific…

Continue reading “CRISPR/Cas9: Big Discovery in Gene Editing” »