CRISPR gene editing has made it possible to cure sickle cell disease, which affects millions worldwide, but most people with the condition won’t be able to afford the cost of the treatment.
Recent advances in human stem cell-derived brain organoids promise to replicate critical molecular and cellular aspects of learning and memory and possibly aspects of cognition in vitro. Coining the term “organoid intelligence” (OI) to encompass these developments, we present a collaborative program to implement the vision of a multidisciplinary field of OI. This aims to establish OI as a form of genuine biological computing that harnesses brain organoids using scientific and bioengineering advances in an ethically responsible manner. Standardized, 3D, myelinated brain organoids can now be produced with high cell density and enriched levels of glial cells and gene expression critical for learning. Integrated microfluidic perfusion systems can support scalable and durable culturing, and spatiotemporal chemical signaling.
Forget about He Jiankui, the Chinese scientist who created gene-edited babies. Instead, when you think about gene editing you should think of Victoria Gray, the African-American woman who says she’s been cured of her sickle-cell disease symptoms.
This week in London, scientists are gathering for the Third International Summit on Human Genome Editing. It’s gene editing’s big event, where researchers get to awe the audience with their new ability to modify DNA—and ethicists get to worry about what it all means.
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In this Ask Me Anything interview, Prof. Matt Kaeberlein discusses the evidence (and lack thereof) behind popular anti-aging supplements and interventions. Starting from his current research on rapamycin for healthy longevity in dogs (The Dog Aging Project), he describes the promises and perils of anti-aging medicine and shares with us some tips on how to become better critical thinkers and protect us from hype and snake oil.
Continue reading “Anti-aging Supplements: Science, Snake Oil, and How Do We Know?” »
Artificial Intelligence AI
🖤 Become an AI & Robots fan & get access to perks: https://www.youtube.com/channel/UCi-vwe-lm_tgxEdlxf690Aw.
Continue reading “Singularity Timeline | Is Super Artificial Intelligence The END of Humanity?” »
A team of researchers from Michigan State University’s College of Veterinary Medicine has made a discovery that may have implications for therapeutic gene editing strategies, cancer diagnostics and therapies and other advancements in biotechnology.
Kathy Meek, a professor in the College of Veterinary Medicine, and collaborators at Cambridge University and the National Institutes of Health have uncovered a previously unknown aspect of how DNA double-stranded breaks are repaired.
Continue reading “DNA repair discovery could improve biotechnology” »
The substance can be administered via intravenous injection and holds the possibility of being used in the treatment of conditions such as heart attacks and traumatic brain injury, among others.
An innovative biomaterial has been developed that, when injected intravenously, reduces inflammation and stimulates cell and tissue repair. The efficacy of this biomaterial in treating heart attack-induced tissue damage was demonstrated through successful testing on both rodent and large animal models. The researchers also provided proof of concept, based on a rodent study, suggesting that the biomaterial may prove beneficial in the treatment of traumatic brain injury and pulmonary arterial hypertension.
“This biomaterial allows for treating damaged tissue from the inside out,” said Karen Christman, a professor of bioengineering at the University of California San Diego, and the lead researcher on the team that developed the material. “It’s a new approach to regenerative engineering.”
Engineers from UNSW Sydney have developed a miniature and flexible soft robotic arm which could be used to 3D print biomaterial directly onto organs inside a person’s body.
3D bioprinting is a process whereby biomedical parts are fabricated from so-called bioink to construct natural tissue-like structures.
Continue reading “3D bioprinting inside the human body could be possible thanks to new soft robot” »
By combining combine genetic and electrical engineering, scientists have developed a new technique for wiring electronics into living matter.
Hey folks, I’m excited to share a new essay with y’all on my proposed route towards nanoscale human brain connectomics. I suggest that synchrotron ‘expansion x-ray microscopy’ has the potential to enable anatomical imaging of the entire human brain with sub-100 nm voxel size and high contrast in around 1 year for a price of roughly $10M. I plan to continue improving this essay over time as I acquire more detailed information and perform more calculations.
For a brief history of this concept: I started exploring this idea during undergrad (working with a laboratory-scale x-ray microscope), but was cut short by the pandemic. Now, I’m working on a PhD in biomedical engineering centered on gene therapy and synthetic biology, but I have retained a strong interest in connectomics. I recently began communication with some excellent collaborators who might be able to help move this technology forward. Hoping for some exciting progress!
By Logan Thrasher Collins.
Continue reading “Feasibility of mapping the human brain with expansion x-ray microscopy” »
