Lifeboat Foundation

Recently, the first attempt in the United States to use the gene editing tool CRISPR to combat cancer appears to have gone well, according to the initial results of a small human trial to determine safety for the approach.

Gene editing is a way to permanently change DNA in order to potentially cure a disease by attacking the root causes. CRISPR is a tool that can cut DNA at a specific spot, allowing genes to be removed or replaced or new genes to be inserted. CRISPR and other similar gene editing tools have long been used in the lab and are finally, after many years, starting to reach human trials for cancer and other diseases.

The approach involved doctors harvesting immune T cells from three cancer patients’ bloodstreams and modifying those cells with CRISPR to make them better able to detect and destroy cancer. Two of the patients have multiple myeloma, and the third has a sarcoma. Essentially, this therapy uses the body’s own immune cells to fight the disease rather than going with the traditional route of using drugs to disrupt the growth and spread of cancer.

Currently over 6,300 people in the UK are waiting for an organ transplant, and sadly everyday around three people die waiting. In efforts to reduce the reliance on organ donors and improve the outlook for patients, alternative sources of organs are being explored by several research groups.

In a study recently published in Nature Biomedical Engineering, bioengineered livers created by decellularization and recellularization were implanted into pigs, where they were able to sustain continuous perfusion for up to 15 days. We spoke to Miromatrix’s CEO, Dr Jeff Ross, to learn more about the study and how it advances the state of bioengineering organs.

Anna MacDonald (AM): What are some of the main challenges faced when creating bioengineered organs?

NASA has tentative plans for a manned mission to Mars sometime in the 2030s. Between now and then, there’s still much that needs to be sorted. To start, massive dust storms, high levels of radiation, low temperatures and a lack of water make the Martian surface an unfriendly place for long-term visits. Taming it for human life will likely prove one of the most demanding and complex engineering puzzles in human history. With those extraordinary obstacles in mind, in 2015 NASA announced the 3D-Printed Habitat Challenge: an open call asking designers and architects outside the traditional aerospace industry to create plans for Martian living centred around 3D printing. One of 10 finalists announced in 2019, this plan from the design practices HASSELL and Eckersley O’Callaghan envisions teams of 3D-printing robots building a protective shield on the Martian surface several months in advance of a human landing. Upon arrival, astronauts would then work alongside the autonomous robots to piece together an inflatable, modular habitat.

Video by LightField London.

I am in shock… Google suddenly as yahoo are allowing conjecture and mendacity be seen as public or scientific opinion. Here is another confused mind who towards the end of her rant quotes Christian scripture as basis to stop Life extension-Transhumanism???

When I say to these minds Behold the leader of Christianity stood for Life abundant-Super Longevity and I can prove such. No matter what lost evangelist or preacher tells you Jesus was a medical researcher of extraordinary magnitude…

NOW BEHOLD THE LOST in this article… https://www.rodofironministries.com/…/transhumanism-and-imm… Respect r.p.berry & AEWR wherein aging now ends we have found the many causes of aging and we have located an expensive cure. We search for partners-investors to now join us in agings end… gerevivify.blogspot.com/

Continue reading “Transhumanism and Immortality” »

The quest to live longer and healthier is not new. But the concept of reversing aging has recently stunned both the scienftific community and the public in general. Scientists have been able to reverse aging by 2.5 years to some participants in a groundbreaking experiment in the field of age reversal.

World leading scientists in the field of aging like David Sinclair think that aging is the ultimate disease that needs a cure. If scientsits were able to shed 2.5 years to the participants genomic age, the question raises itself, are we going to see an age reversal of a decade or more in the coming years?

Continue reading “Can We Live Longer” »

Amidst rising hopes for using CRISPR gene editing tools to repair deadly mutations linked to conditions like cystic fibrosis and sickle cell disease, a study in Communications Biology describes a new innovation that could accelerate this work by rapidly revealing unintended and potentially harmful changes introduced by a gene editing process.

“We’ve developed a new process for rapidly screening all of the edits made by CRISPR, and it shows there may be many more unintended changes to DNA around the site of a CRISPR repair than previously thought,” said Eric Kmiec, Ph.D., director of ChristianaCare’s Gene Editing Institute and the principle author of the study.

The study describes a new tool developed at the Gene Editing Institute that in just 48 hours can identify “multiple outcomes of CRISPR-directed gene editing,” a process that typically required up to two months of costly and complicated DNA analysis.

Over 116,000 people in the US are on organ transplant waiting lists because of a shortage in healthy donated organs. Dr. Wells and his team have been harnessing the power of stem cells to grow miniature versions of human organs in the laboratory. Today, mini organs are being used to help diagnose patients and improve care and Dr. Wells and colleagues are working to generate lab grown organs for future transplantation into patients. Screen reader support enabled. FB: James Wells, LinkedIn: James Wells As a Developmental Biologist, Jim Wells has spent the past two decades trying to uncover how a single cell gives rise to tissues, organs and eventually a whole organism. With this information as a roadmap, he has pioneered approaches to generate mini organs (organoids) from stem cells in the laboratory. Dr. Wells is now part of a team that is using tissue engineering to generate bigger and more functional organs in the lab that can be used for transplantation into patients in the future. Dr. Wells is a professor of Pediatrics at the Cincinnati Children’s Hospital Medical Center. He is in the Division of Developmental Biology and where he established the human pluripotent stem cell facility. He is also the Director for Basic Research in the Division of Endocrinology and was appointed Chief Scientific Officer of the Center for Stem Cell and Organoid Medicine. As a Developmental Biologist, Jim Wells has spent the past two decades trying to uncover how a single cell gives rise to tissues, organs and eventually a whole organism. With this information as a roadmap, he has pioneered approaches to generate mini organs (organoids) from stem cells in the laboratory. Dr. Wells is now part of a team that is using tissue engineering to generate bigger and more functional organs in the lab that can be used for transplantation into patients in the future. Dr. Wells is a professor of Pediatrics at the Cincinnati Children’s Hospital Medical Center. He is in the Division of Developmental Biology and where he established the human pluripotent stem cell facility. He is also the Director for Basic Research in the Division of Endocrinology and was appointed Chief Scientific Officer of the Center for Stem Cell and Organoid Medicine. This talk was given at a TEDx event using the TED conference format but independently organized by a local community.