In a recent study in Nature Communications, researchers increased synaptic serotonin through a selective serotonin-releasing agent (SSRA), fenfluramine, to investigate its impact on human behavior.
Neuroscience research concentrates on the function of central serotonin (5HT) in human behavior, specifically the impact of selective serotonin reuptake inhibitors (SSRIs). Serotonin is necessary for several actions, including eating, sexual function, and goal-directed cognition.
It is difficult to determine the causal relationship between increased synaptic 5-HT and behavior in humans via SSRIs due to SSRIs’ complicated effects on 5-HT and colocalized neurotransmitter systems. A low dose of fenfluramine, approved for the treatment of Dravet epilepsy in 2020, directly and swiftly elevates synaptic 5-HT without altering extracellular dopamine concentrations in mood control areas.
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