We evaluate the top-bottom interference contribution to the fully inclusive Higgs production cross section at next-to-next-to-leading order in QCD. Although bottom-quark-mass effects are power suppressed, the accuracy of state-of-the-art theory predictions makes an exact determination of this effect indispensable. The total effect of the interference at 13 TeV is −1.99_-0.15^+0.30 pb, while the pure mathcalO(alpha_s^4)$ correction is 0.43 pb. With this result, we address one of the leading theory uncertainties of the cross section.
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