Scientists from the Berlin Institute of Health at Charité (BIH) and Open Targets together with colleagues from the University of Cambridge, and Addenbrooke’s Hospital in Cambridge, U.K., uncovered mechanisms driving regeneration of the liver during chronic liver disease. This regenerative process allows the liver to repair itself when chronically injured but could also result in progression toward cancer.
The researchers were able to demonstrate this first by performing single-cell analyses on many biopsies obtained from patients with progressive metabolic dysfunction-associated steatotic liver disease (MASLD).
The results obtained in vivo were validated using cultured organoids in the laboratory. The scientists have now published their results in the journal Nature.
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