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Jan 17, 2023

Machine learning dissection of human accelerated regions in primate neurodevelopment

Posted by in categories: biotech/medical, robotics/AI

Whalen et al. couple deep learning with functional assays in chimpanzee and human cells to interrogate the neurodevelopmental enhancer potential of 2,645 human accelerated regions (HARs). Activity is dominated by cis rather than trans effects, and compensatory changes are identified as a driver of rapid HAR evolution.

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