Nature uses 20 canonical amino acids as building blocks to make proteins, combining their sequences to create complex molecules that perform biological functions.
But what happens with the sequences not selected by nature? And what possibilities lie in constructing entirely new sequences to make novel (de novo) proteins bearing little resemblance to anything in nature?
That’s the terrain where Michael Hecht, professor of chemistry, works with his research group. Recently, their curiosity for designing their own sequences paid off.
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