Alzheimer’s disease has long thwarted our best efforts to pinpoint its underlying causes. Now, a new study in mice suggests that ‘poisonous flowers’ bulging with cellular debris could be the root source of one hallmark of the wretched disease and a beautifully sinister sign of a failing waste disposal system inside damaged brain cells.
The study, led by neuroscientist Ju-Hyun Lee of New York University (NYU) Langone, challenges the long-standing idea that the build-up of a protein called amyloid-beta between neurons is a crucial first step in Alzheimer’s disease, the most common form of dementia.
Instead, it suggests that damage to neurons may take root inside cells well before amyloid plaques fully form and clump together in the brain, a finding which could provide new therapeutic possibilities.
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