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DNA-binding proteins from volcanic lakes could improve disease diagnosis

Scientists have uncovered new DNA-binding proteins from some of the most extreme environments on Earth and shown that they can improve rapid medical tests for infectious diseases. The work has been published in Nucleic Acids Research. The international research team, led by Durham University and working with partners in Iceland, Norway and Poland, analyzed genetic material from Icelandic volcanic lakes and deep-sea vents more than two kilometers below the surface of the North Atlantic Ocean.

Nature is the world’s largest source of useful enzymes, but many remain undiscovered. By using next-generation DNA sequencing, the researchers were able to search huge databases containing millions of potential proteins.

This approach allowed them to identify previously unknown proteins that bind to single-stranded DNA and remain stable under harsh conditions such as high temperatures, extreme pH or high salt levels.

Deep learning detects foodborne bacteria within three hours by eliminating debris misclassifications

Researchers have significantly enhanced an artificial intelligence tool used to rapidly detect bacterial contamination in food by eliminating misclassifications of food debris that looks like bacteria. Current methods to detect contamination of foods such as leafy greens, meat and cheese, which typically involve cultivating bacteria, often require specialized expertise and are time-consuming—taking several days to a week.

Luyao Ma, an assistant professor at Oregon State University, and her collaborators from the University of California, Davis, Korea University and Florida State University, have developed a deep learning-based model for rapid detection and classification of live bacteria using digital images of bacteria microcolonies. The method enables reliable detection within three hours. The findings are published in the journal npj Science of Food.

Their latest breakthrough involves training the model to distinguish bacteria from microscopic food debris to improve its accuracy. A model trained only on bacteria misclassified debris as bacteria more than 24% of the time. The enhanced model, trained on both bacteria and debris, eliminated misclassifications.

New nanoparticles remove melanoma tumors in mice with low-power near-infrared laser

Researchers at Oregon State University have developed and tested in a mouse model a new type of nanoparticle that enables the removal of melanoma tumors with a low-power laser. After the systemically administered nanoparticles accumulate in cancerous tissue, exposure to near-infrared light causes them to heat up and destroy the melanoma cells, leaving healthy tissue unharmed.

The study led by Olena Taratula and Prem Singh of the Oregon State University College of Pharmacy represents a huge step toward solving a persistent problem with using photothermal therapy to treat melanoma, the deadliest form of skin cancer: Conventional nanoparticles require lasers with power densities that are unsafe for the skin. Findings were published in Advanced Functional Materials.

Taratula, associate professor of pharmaceutical sciences, and Singh, a postdoctoral researcher in Taratula’s lab, based their new theranostic platform —it can be used for both treatment and diagnosis—on gold nanorods. The nanorods are coated with an iron-cobalt shell and tightly loaded with a dye that heats up upon exposure to near-infrared light—invisible, low-frequency radiation able to penetrate deeply into human tissue.

Anthropic’s ‘anonymous’ interviews cracked with an LLM

In December, the artificial intelligence company Anthropic unveiled its newest tool, Interviewer, used in its initial implementation “to help understand people’s perspectives on AI,” according to a press release. As part of Interviewer’s launch, Anthropic publicly released 1,250 anonymized interviews conducted on the platform.

A proof-of-concept demonstration, however, conducted by Tianshi Li of the Khoury College of Computer Sciences at Northeastern University, presents a method for de-anonymizing anonymized interviews using widely available large language models (LLMs) to associate responses with the real people who participated. The paper is published on the arXiv preprint server.

Anomalous magnetoresistance emerges in antiferromagnetic kagome semimetal

Researchers from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences (CAS), in collaboration with researchers from the Institute of Semiconductors of CAS, revealed anomalous oscillatory magnetoresistance in an antiferromagnetic kagome semimetal heterostructure and directly identified its corresponding topological magnetic structures. The results are published in Advanced Functional Materials.

Antiferromagnetic kagome semimetals, characterized by a strong interplay of geometric frustration, spin correlations, and band topology, have emerged as a promising platform for next-generation antiferromagnetic topological spintronics.

In this study, the researchers fabricated an FeSn/Pt heterostructure based on an antiferromagnetic kagome semimetal. By breaking inversion symmetry at the interface, the researchers introduced and tuned the Dzyaloshinskii-Moriya interaction, enabling effective control of spin configurations in the FeSn layer.

How charges invert a long-standing empirical law in glass physics

If you’ve ever watched a glass blower at work, you’ve seen a material behaving in a very special way. As it cools, the viscosity of molten glass increases steadily but gradually, allowing it to be shaped without a mold. Physicists call this behavior a strong glass transition, and silica glass is the textbook example. Most polymer glasses behave very differently, and are known as fragile glass formers. Their viscosity rises much more steeply as temperature drops, and therefore they cannot be processed without a mold or very precise temperature control.

There are other interesting differences between different glass formers. Most glasses exhibit relaxation behavior that deviates strongly from a single-exponential decay; this means that their relaxation is characterized by a broad spectrum of relaxation times, and is often associated with dynamic heterogeneities or cooperative rearrangements.

A long-standing empirical rule links the breadth of the relaxation spectrum to the fragility of the glass: strong glass formers such as silica tend to have a narrow relaxation spectrum, while fragile glass formers such as polymers have a much broader relaxation spectrum.

When heat flows backwards: A neat solution for hydrodynamic heat transport

When we think about heat traveling through a material, we typically picture diffusive transport, a process that transfers heat from high-temperature to low-temperature as particles and molecules bump into each other, losing kinetic energy in the process. But in some materials, heat can travel in a different way, flowing like water in a pipeline that—at least in principle—can be forced to move in a direction of choice. This second regime is called hydrodynamic heat transport.

Heat conduction is mediated by movement of phonons, which are collective excitations of atoms in solids, and when phonons spread in a material without losing their momentum in the process, you have phonon hydrodynamics.

The phenomenon has been studied theoretically and experimentally for decades, but is becoming more interesting than ever to experimentalists because it features prominently in materials like graphene, and could be exploited to guide heat flow in electronics and energy storage devices.

Five ways quantum technology could shape everyday life

The unveiling by IBM of two new quantum supercomputers and Denmark’s plans to develop “the world’s most powerful commercial quantum computer” mark just two of the latest developments in quantum technology’s increasingly rapid transition from experimental breakthroughs to practical applications.

There is growing promise of quantum technology’s ability to solve problems that today’s systems struggle to overcome, or cannot even begin to tackle, with implications for industry, national security and everyday life.

So, what exactly is quantum technology? At its core, it harnesses the counterintuitive laws of quantum mechanics, the branch of physics describing how matter and energy behave at the smallest scales. In this strange realm, particles can exist in several states simultaneously (superposition) and can remain connected across vast distances (entanglement).

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