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Inflammation linked with Alzheimer’s, reduced cognition and brain fog

Several newly published studies are reporting evidence affirming a growing hypothesis that links inflammation with cognitive deficits. As well as associating inflammation with the cognitive deficits seen in conditions such as bipolar disorder and Alzheimer’s, some research is even suggesting low-grade systemic inflammation in healthy subjects can result in mental sluggishness.

For some time patients suffering from chronic inflammatory conditions such as rheumatoid arthritis or inflammatory bowel disease have reported mild cognitive deficits in association with their disease. Despite a number of correlational studies finding connections between inflammation and cognitive performance, homing in on any clear causal links has been a little tricky for scientists.

“Scientists have long suspected a link between inflammation and cognition, but it is very difficult to be clear about the cause and effect,” explains Ali Mazaheri, from the University of Birmingham. “For example, people living with a medical condition or being very overweight might complain of cognitive impairment, but it’s hard to tell if that’s due to the inflammation associated with these conditions or if there are other reasons.”

Rejuvenation: If I could turn back time … — Longevity.Technology

Last week, the BBC reported on the plight of axolotls in Mexico City, which are under threat of extinction. [1] The risk to these creatures is made doubly concerning when you consider their incredible ability to regenerate and apparent immunity to cancer, which is of great interest to scientists and companies working in the Longevity sector. One such company is Bioquark, a Philadelphia-based life sciences company that is working on the development of combinatorial biologics for the rejuvenation and repair of human organs and tissues. Among its clinical plans, it lists the development of therapeutic products for cancer reversion, organ repair and regeneration, and even brain death resuscitation. Nothing major then!

Bioquark has developed a novel combinatorial biologic called BQ-A, which mimics the regulatory biochemistry of the living human egg (oocyte) immediately following fertilization. While ooplasm-based reprogramming has been studied in experiments such as in-vitro fertilization and cloning, Bioquark claims it is the first company to apply it to somatic tissue in mammals.

We spoke with Bioquark’s CEO, Ira Pastor, a 30-year veteran of the pharmaceutical industry, to find out more about the company and where it’s headed.

The Ethical Implications of Mind-Machine Meld | Future You | NPR

The fast-moving development of brain-machine interfaces got a boost when Elon Musk announced the work for Neuralink, his new company devoted to implantable devices to enhance cognition and better marry our brains with super-computing. His competitor, fellow tech entrepreneur Bryan Johnson of Kernel, weighs in on why he thinks advancing cognition can solve all the other problems in the world. But tech ethicist Tristan Harris says not so fast — we haven’t properly accounted for what existing tech has already done to us. Think things through with this brainy episode of Future You with Elise Hu.

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Longevity And Health

Education and bravery are the key to our survival. In this article we dig into the correlation between health and longevity.


With so many supplement salesman and scientists talking about longevity it can get confusing as to exactly what that might mean. Of course we all want to live as long as we can but most would agree to it only if they were able to be healthy and active. After all how would life be worth it if you were confined to a bed or wheelchair in constant pain?

As we improve health we also extend life. One drawback to extending life is that we face health problems we might have avoided by simply not being alive. However as we extend life we will also extend health and find ways to cure all diseases. For most of humanity throughout the ages Cancer or Alzheimer’s was rarely a cause for concern. Cancer and Alzheimer’s was not as prevalent because most people did not live long enough to be stricken with them. Many humans died from infections, starvation, and injury and thus the expected life span was much lower than today. Every time a new advancement is made in healthcare we improve the odds of living longer. Hospitals, handwashing, and vaccines all improved a human beings chance of survival and also their chance of contracting a new or otherwise unusual disease.

Brent Nally interviews Dr. Michael Fossel about Telocyte and telomerase gene therapy on 11/16/2019

Haven’t heard from Fossel in awhile. This is long but well indexed in the notes.


My mission is to drastically improve your life by helping you break bad habits, build and keep new healthy habits to make you the best version of yourself.

This video me, Brent Nally, interviewing Dr. Michael Fossel about Telocyte and telomerase gene therapy on November 16, 2019.

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