Lifeboat Foundation

New research on brain ageing and mitochondria from Salk Institute.

Thanks to a new technique, researchers from the Salk Institute’s Gage laboratory have shown that impaired energy production might be a reason why human brains are susceptible to age-related diseases in the first place [1].

In particular, Salk scientists observed that induced neurons (iNs) obtained from fibroblasts of older individuals had dysfunctional mitochondria and therefore decreased energy levels compared to younger neurons. Out-of-shape mitochondria have previously been implicated in degenerative brain diseases, such as Alzheimer’s and Parkinson’s, and this finding might help reveal more about the connection between these diseases and this particular hallmark of aging.

Continue reading “Mitochondrial dysfunction in aged brain cells” »

http://www.thepathmag.com/can-you-actually-hack-your-dna-to-slow-down-aging/

Many technologies / interventions progressing down the development pathways in the coming years — but there are a lot of free, common sense adjustments you can make today:

http://www.blogtalkradio.com/entrepreneursempower/2018/06/03…ira-pastor

I t’s an odd thing for someone to say about neurons: “Let’s see if anyone is awake.” And it’s an even odder thing to hear in a cavernous, half-furnished office suite where one whole room is occupied only by copy machines and a lonely foosball table.

Not far from that foosball table, Oshiorenoya Agabi and Benjamin Sadrian are sitting in a lab at their startup, Koniku, in Berkeley, California. Agabi founded the company, and Sadrian is a senior neuroscientist. They are toggling between a microscope and a screen full of blue graphs, looking for signs of activity in a cluster of neurons. Sadrian pauses as he scrolls through slightly fuzzy readouts on the screen, reminiscent of stock charts with buzz cuts. “I wish you’d come later, even tomorrow,” he sighs.

These readouts measure signals inside cells, and Agabi and Sadrian are looking for spikes that would show Koniku’s neurons reacting to a chemical Sadrian exposed them to moments ago. When we examined them under the microscope, they glowed a faint neon green, which indicates they’re starting to mature. A few tentative dendrites reached out into the void, the neurons just beginning to form connections with one another. But the telltale spikes don’t materialize on the screen. At just six days old, these neurons are still too young to do the jobs they’ve been engineered to do.

Continue reading “The Birth of Wetware” »

With the ability to be coaxed into different kinds of mature cell types, induced pluripotent stem cells (iPSCs) hold all kinds of potential in the world of regenerative medicine. One of the many possibilities could be repairing damaged hearts, something that will soon be put to the test for the first time ever in newly approved clinical trials in Japan.

Since emerging from the laboratory of researcher Shinya Yamanaka in Japan in 2006, the potential of iPSCs has been explored in all kinds of promising research efforts. We have seen them implanted into rabbits to restore their vision, become brain tumor predators, and turned into precursor cells for human organs.

IPSCs are created by first harvesting cells from body tissues and then infecting them with a virus, in turn introducing them to carefully selected genes that return them to their immature state. From there they can develop into any cell in the body, a capability so powerful it earned Yamanaka a Nobel Prize in 2012.

On Thursday, an international team of scientists announced a new explanation for the evolution of brain size expansion: Unique genes that, to date, have only been found in humans. They’re called NOTCHN2NL genes and so far the scientists have identified eight different versions of them.

Microsoft’s CEO said the company could potentially use technology to help people with locked-in syndrome.

https://www.engadget.com/…/3D-printed-brain-medical-imagin…/

There are almost limitless possibilities when it comes to 3D printing. Design your own color-changing jewelry? Fine. Fabricate your own drugs? No problem. Print an entire house in under 24 hours? Sure! Now, researchers have come up with a fast and easy way to print palm-sized models of individual human brains, presumably in a bid to advance scientific endeavours, but also because, well, that’s pretty neat.

In theory, creating a 3D printout of a human brain has been done before, using data from MRI and CT scans. But as MIT graduate Steven Keating found when he wanted to examine his own brain following his surgery to remove a baseball-sized tumour, it’s a slow, cumbersome process that doesn’t reveal any important areas of interest.

Continue reading “You’ll soon be able to get a 3D printed model of your brain” »

A new wonderful breakthrough of our time.

Scientists raise ethical concerns as the brain cells of decapitated pigs are kept alive for 36 hours.