Lifeboat Foundation

Unless we solve the problem of consciousness, the endeavour remains a dead end.

Science and Technology: I don’t want to die.

A friend of the academic, who died in the US in 2021, says his brain has been cryonically preserved in accordance with his final wishes.

A new study suggests abdominal fat could impact brain health and cognition among people with a high risk of developing Alzheimer’s disease. Researchers found that middle-aged males at risk for Alzheimer’s who had higher amounts of pancreatic fat had lower cognition and brain volumes.

An exploration of brain augmentation especially that which involves neural dust. The new JMG Clips channel for sleep!https://youtu.be/Lf2iz6LqCxQ?si=S-qdipBH…

New study links dopamine and serotonin changes in a brain region to social perception and decision-making regarding offer acceptance.

Scientists unravel dopamine-serotonin dynamics in first-in-humans study, unveiling social decision-making during awake surgery in Parkinson’s patients’ tracking economic exchange.

Yang Dan aims to elucidate the mechanisms in the mammalian brain that control sleep. Find out more about Dan’s research in this feature.

Summary: Researchers have developed the first stem cell culture method that accurately models the early stages of the human central nervous system (CNS), marking a significant breakthrough in neuroscience. This 3D human organoid system simulates the development of the brain and spinal cord, offering new possibilities for studying human brain development and diseases.

By using patient-derived stem cells, the model can potentially lead to personalized treatment strategies for neurological and neuropsychiatric disorders. The innovation opens new doors for understanding the intricacies of the human CNS and its disorders, surpassing the capabilities of previous models.

A new study from a team of McGill University and Vanderbilt University researchers is shedding light on our understanding of the molecular origins of some forms of autism and intellectual disability.

For the first time, researchers were able to successfully capture atomic resolution images of the fast-moving ionotropic glutamate receptor (iGluR) as it transports calcium. iGluRs and their ability to transport calcium are vitally important for many brain functions such as vision or other information coming from sensory organs. Calcium also brings about changes in the signaling capacity of iGluRs and nerve connections, which are key cellular events that lead to our ability to learn new skills and form memories.

IGluRs are also key players in brain development and their dysfunction through genetic mutations has been shown to give rise to some forms of autism and intellectual disability. However, basic questions about how iGluRs trigger biochemical changes in the brain’s physiology by transporting calcium have remained poorly understood.

Researchers report in the journal Cell that ancient viruses may be to thank for myelin—and, by extension, our large, complex brains.

The team found that a retrovirus-derived genetic element or “retrotransposon” is essential for myelin production in mammals, amphibians, and fish. The gene sequence, which they dubbed “RetroMyelin,” is likely a result of ancient viral infection, and comparisons of RetroMyelin in mammals, amphibians, and fish suggest that retroviral infection and genome-invasion events occurred separately in each of these groups.

“Retroviruses were required for vertebrate evolution to take off,” says senior author and neuroscientist Robin Franklin of Altos Labs-Cambridge Institute of Science. “If we didn’t have retroviruses sticking their sequences into the vertebrate genome, then myelination wouldn’t have happened, and without myelination, the whole diversity of vertebrates as we know it would never have happened.”