Lifeboat Foundation

Eliminating old, dysfunctional cells in human fat also alleviates signs of diabetes, researchers from UConn Health report. The discovery could lead to new treatments for Type 2 diabetes and other metabolic diseases.

The cells in your body are constantly renewing themselves, with older cells aging and dying as new ones are being born. But sometimes that process goes awry. Occasionally damaged cells linger. Called senescent cells, they hang around, acting as a bad influence on other cells nearby. Their bad influence changes how the neighboring cells handle sugars or proteins and so causes metabolic problems.

Type 2 diabetes is the most common metabolic disease in the US. About 34 million people, or one out of every 10 inhabitants of the US, suffers from it, according to the Centers for Disease Control and Prevention (CDC). Most people with diabetes have insulin resistance, which is associated with obesity, lack of exercise and poor diet. But it also has a lot to do with senescent cells in people’s body fat, according to new findings by UConn Health School of Medicine’s Ming Xu and colleagues. And clearing away those senescent cells seems to stop diabetic behavior in obese mice, they report in the 22 November issue of Cell Metabolism. Ming Xu, assistant professor in the UConn Center on Aging and the department of Genetics and Genome Sciences at UConn Health, led the research, along with UConn Health researchers Lichao Wang and Binsheng Wang as major contributors. Alleviating the negative effects of fat on metabolism was a dramatic result, the researchers said.

“Fountain is an example of a biotech company emerging as a direct result of basic research, in this case the biology of aging,” said Dr Rando, founder and chairman of Fountain. “The company’s screening and discovery platform is built upon foundational research showing that the age of a cell can be modulated by factors in the cell’s environment. By identifying compounds that work through these pathways, we seek to restore youthful resilience to cells and tissues, leading to therapies that treat or even prevent chronic diseases of aging.”

Longevity funding: Eli Lilly and R42 Group join the party as Khosla-backed biopharma brings total Series A to $26 million.

Incredible new videos show stem cells escaping from hair follicles, which could provide insight on a new, potentially reversible mechanism of hair loss.

Stem cells contribute to tissue regeneration, and they are thought to play an important role in age-related decline — so much so that stem cell exhaustion is one of the hallmarks of aging. These stem cells reside in “compartments” in various tissues. In the hair, the stem cell compartment, known as the bulge, is adjacent to the hair follicle.

Continue reading “Hair Loss Reversal? Stem Cell Escape Identified!” »

In this videoclip, Professor David Sinclair from Harvard University addresses one of the most promising technologies his lab is working on to slow and reverse aging.

To watch the entire video from which this videoclip was made, please click here: https://youtu.be/9rB89ydZoRo

This month, the UW team upped their game.

Tapping into both AlphaFold and RoseTTAFold, they tweaked the programs to predict which proteins are likely to tag-team and sketched up the resulting complexes into a 3D models.

Using AI, the team predicted hundreds of complexes—many of which are entirely new—that regulate DNA repair, govern the cell’s digestive system, and perform other critical biological functions. These under-the-hood insights could impact the next generation of DNA editors and spur new treatments for neurodegenerative disorders or anti-aging therapies.

Very well said and in just one minute by Dr. Eric Verdin, CEO & President of the Buck Institute for Research on Aging.

Videoclip of the intervention of Dr. Eric Verdin, CEO & President of the Buck Institute for Research on Aging, referring to Longevity as an investment opportunity.

Continue reading “Longevity as an investment opportunity | Videoclip with Dr. Eric Verdin (S/T in Spanish)” »

It’s the BIG one! The FINAL LEVEL on the Kardashev Scale! In this video, Unveiled discovers what the world would be like if humanity could complete the Kardashev Scale and become the most advanced civilisation it’s possible to be… This goes beyond gods and monsters, to the incredible, immortal heart of the omniverse!

Let us know what you think in the comments!

Continue reading “What If Humanity Was a Type VII Civilization? | Unveiled” »

In one of the mysteries of mammalian development, every cell in the early female embryo shuts down one of its two copies of the X chromosome, leaving just one functional. For years, the mechanics behind this X chromosome inactivation have been murky, but scientists from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have now taken a major step forward in understanding the process.

Their findings, based on research on mouse stem cells, upend previous assumptions about how X inactivation is initiated in female embryos and could lead to new ways to treat some genetic disorders, as well as a better understanding of how genes on other chromosomes are silenced.

“X inactivation is one of the most fundamentally important processes in development, and I think this study is a slam dunk in finally understanding it,” said Kathrin Plath, a professor of biological chemistry and senior author of the paper, published in the journal Cell.

https://www.youtube.com/watch?v=X1TYqoR-qVA

We explore human enhancement and personal performance hacking with Matt Ward (@mattwardio), host of The Disruptors podcast, startup investor, adviser, and business innovation consultant. Matt and I thought it would be fun to do two episodes, one here on MIND & MACHINE and the other on The Disruptors, where we explore what we’ve learned, the ideas we’ve formed and our takeaways across all these different fields that we cover.

So with this episode here on MIND & MACHINE, we focus on human enhancement — technologies that are extending lifespan and enhancing human capability. Then we get into what Matt and I are doing currently to maximize our own performance capabilities — our ability to think more clearly, to live more energetic vibrant lives… which is all heavily informed by all these amazing guests across these different fields that we explore.

Continue reading “Human Enhancement & Personal Performance Hacking with Matt Ward of ‘The Disruptors’” »