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Category: life extension – Page 193

Advancing human healthspan: Longevity Summit Dublin’s agenda unveiled

The Longevity Summit Dublin is dedicated to the recognition of emerging research developments aimed at extending the human healthspan. This much-anticipated event brings together leading scientists from around the world, fostering collaboration and knowledge exchange in pursuit of this critical objective.

The summit serves as a premier platform for showcasing the latest research and innovations within the longevity industry. Notably, keynote presentations by esteemed experts in the aging field provide valuable insights into the advancements being made towards enhancing overall well-being and extending lifespans.

Longevity. Technology: Scheduled to take place from the 17th to the 20th of August 2023, the Longevity Summit Dublin boasts a remarkable lineup of over 40 pioneering scientists, researchers and executives, as well as high net-worth investors – all of the attendees share a common focus on addressing the challenges posed by chronic diseases.

Daniel Dennett on Consciousness, Virtual Immortality, and Panpsychism | Closer To Truth Chats

Daniel Dennett discusses the nature of consciousness, if consciousness is an illusion, artificial intelligence and virtual immortality, and how he covers all of this in his book, Just Deserts: Debating Free Will, co-authored with Gregg D. Caruso.

Just Deserts: Debating Free Will https://www.amazon.com/Just-Deserts-Debating-Free-Will/dp/15…atfound-20
Read an excerpt https://www.closertotruth.com/articles/book-excerpt-just-deserts.

Daniel Clement Dennett is a philosopher, writer, and cognitive scientist whose research centers on the philosophy of mind, philosophy of science, and philosophy of biology, particularly as those fields relate to evolutionary biology and cognitive science.

Watch more Closer To Truth interviews with Daniel Dennett: https://bit.ly/2N6W7Me.

Register for free at closertotruth.com for subscriber-only exclusives: http://bit.ly/2GXmFsP

Closer to Truth presents the world’s greatest thinkers exploring humanity’s deepest questions. Discover fundamental issues of existence. Engage new and diverse ways of thinking. Appreciate intense debates. Share your own opinions. Seek your own answers.

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Michael Levin | Cell Intelligence in Physiological and Morphological Spaces

Talk kindly contributed by Michael Levin in SEMF’s 2022 Spacious Spatiality.

https://semf.org.es/spatiality.

TALK ABSTRACT
Life was solving problems in metabolic, genetic, physiological, and anatomical spaces long before brains and nervous systems appeared. In this talk, I will describe remarkable capabilities of cell groups as they create, repair, and remodel complex anatomies. Anatomical homeostasis reveals that groups of cells are collective intelligences; their cognitive medium is the same as that of the human mind: electrical signals propagating in cell networks. I will explain non-neural bioelectricity and the tools we use to track the basal cognition of cells and tissues and control their function for applications in regenerative medicine. I will conclude with a discussion of our framework based on evolutionary scaling of intelligence by pivoting conserved mechanisms that allow agents, whether designed or evolved, to navigate complex problem spaces.

TALK MATERIALS
· The Electrical Blueprints that Orchestrate Life (TED Talk): https://www.ted.com/talks/michael_levin_the_electrical_bluep…trate_life.
· Michael Levin’s interviews and presentations: https://ase.tufts.edu/biology/labs/levin/presentations/
· Michael Levin’s publications: https://ase.tufts.edu/biology/labs/levin/publications/
· The Institute for Computationally Designed Organisms (ICDO): https://icdorgs.org/

MICHAEL LEVIN
Department of Biology, Tufts University: https://as.tufts.edu/biology.
Tufts University profile: https://ase.tufts.edu/biology/labs/levin/
Wyss Institute profile: https://wyss.harvard.edu/team/associate-faculty/michael-levin-ph-d/
Wikipedia: https://en.wikipedia.org/wiki/Michael_Levin_(biologist)
Google Scholar: https://scholar.google.com/citations?user=luouyakAAAAJ
Twitter: https://twitter.com/drmichaellevin.
LinkedIn: https://www.linkedin.com/in/michael-levin-b0983a6/

SEMF NETWORKS

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Probiotics vs Cognitive Decline: Gut Health Key to Aging Brain Fitness

Summary: Probiotics might play a vital role in preventing cognitive decline associated with aging. By providing participants suffering from mild cognitive impairment with the probiotic Lactobacillus rhamnosus GG for three months, researchers observed enhanced cognitive performance and gut microbiome modifications.

The study suggests that altering gut microbiome might be a strategic approach to enhancing cognitive function in individuals with mild cognitive impairment. If replicated, these findings could revolutionize preventive strategies in cognitive health using gut microbiome-focused approaches.

The (Secret)ome to Longevity — Summary # 1

A healthy immune system: the ultimate balancing act

The immune system is comprised of innate and adaptive immune responses, both of which are crucial in maintaining our health. The innate immune response is the first line of defense that immediately works to prevent the spread of pathogens and tumors.1 The adaptive immune response is a more sophisticated, secondary response that is specialized to clear specific pathogens and provide long-lasting immunity.2

The efficacy of these two systems depends on balanced inflammatory and anti-inflammatory responses, referred to as immunomodulation. For example, upon injury or infection, macrophages secrete molecules that promote inflammation to dilate blood vessels and recruit other immune cells to the damaged site. Once the infection is cleared, the immune system mounts an anti-inflammatory, reparatory response.

New Senolytics from Artificial Intelligence

Recent research published in Nature Communications has used machine learning algorithms to find new compounds that can eliminate senescent cells [1].

Senolytics are molecules that destroy senescent cells. Only a small number of such molecules have been identified, and only two have shown efficacy in clinical trials: dasatinib and quercetin in combination [2]. One of the biggest challenges is that senolytics often only work against specific types of cells. Additionally, some senolytics may work well for one cell type while being toxic to other, non-senescent cell types [3].

There is also a group of senolytics that are used in cancer therapies. However, most of them target pathways that are mutated in cancer. Therefore, they cannot be used as therapeutic agents in different contexts.

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