Does the secret to reaching extreme old age lie in lifestyle or genetics? Story at a glance America’s population is aging, with more people living to be 100. Reaching extreme old age depends on multiple factors like location, gender, lifestyle and parental age of death.
Phil Newman, Founder and CEO, Longevity. Technology at Rejuvenation Startup Summit 2022.
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Advancing Geroscience & Gerotherapeutics — Dr. Nir Barzilai, MD, Albert Einstein College of Medicine.
Dr. Nir Barzilai, MD (https://www.einsteinmed.edu/faculty/484/nir-barzilai/) is the Director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. He is the Ingeborg and Ira Leon Rennert Chair of Aging Research, professor in the Departments of Medicine and Genetics, and member of the Diabetes Research Center and of the Divisions of Endocrinology & Diabetes and Geriatrics.
Dr. Barzilai’s research interests are in the biology and genetics of aging, with one focus of his team on the genetics of exceptional longevity, where they hypothesize and demonstrate that centenarians (those aged 100 and above) may have novel protective genes, which allow the delay of aging or for the protection against age-related diseases. The second focus of his work, for which Dr. Barzilai holds an NIH Merit award, is on the metabolic decline that occurs during aging, and his team hypothesizes that the brain leads this decline with some very interesting neuro-endocrine connections.
Dr. Barzilai is currently leading an international effort to approve drugs that can target aging (Gerotherapeutics). Targeting Aging with METformin (TAME) is a specific study designed to prove the concept that a basket of diseases (multi-morbidities) of aging can be delayed simultaneously, in this protocol by the drug metformin, working with the FDA to approve this approach which will serve as a template for future efforts to delay aging and its diseases in humans.
Dr. Barzilai has received numerous grants, among them ones from the National Institute on Aging (NIA), American Federation for Aging Research, the Ellison Medical Foundation and The Glenn Medical foundation. He has published over 280 peer-reviewed papers, reviews, and textbook chapters. He is an advisor to the NIH on several projects and serves on several editorial boards and is a reviewer for numerous other journals.
Rejuvenating an older person’s blood may now be within reach, based on recent findings from Passegué’s lab published in Nature Cell Biology(link is external and opens in a new window).
Passegué, with her graduate student Carl Mitchell, found that an anti-inflammatory drug, already approved for use in rheumatoid arthritis, can turn back time in mice and reverse some of the effects of age on the hematopoietic system.
Nature article:
https://www.nature.com/articles/s41556-022-01053-0
Young blood may be an elixir for older bodies, rejuvenating aging hearts, muscles, and brains. But how can old blood become young again? Columbia stem cell scientists may have found a way.
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How should we live when we know we must die? This question is posed by the first work of world literature, the Gilgamesh epic. More than 4,000 years ago, Gilgamesh set out on a quest for immortality. Like all Babylonian literature, the saga has survived only in fragments. Nevertheless, scholars have managed to bring two-thirds of the text into readable condition since it was rediscovered in the 19th century.
The Babylonians wrote in cuneiform characters on clay tablets, which have survived in the form of countless fragments. Over centuries, scholars transferred the characters imprinted on the pieces of clay onto paper. Then they would painstakingly compare their transcripts and—in the best case—recognize which fragments belong together and fill in the gaps. The texts were written in the languages Sumerian and Akkadian, which have complicated writing systems. This was a Sisyphean task, one that the experts in the Electronic Babylonian Literature project can scarcely imagine today.
Enrique Jiménez, Professor of Ancient Near Eastern Literatures at LMU’s Institute of Assyriology, and his team have been working on the digitization of all surviving cuneiform tablets since 2018. In that time, the project has processed as many as 22,000 text fragments.
This is more about the current landscape but a bit on the future near the beginning.
In this video Dr de Grey talks the future of LEVF and how the longevity field has evolved and some of the main participants.
Dr. Aubrey de Grey is internationally recognised as the visionary biomedical gerontologist who devised the Strategies for Engineered Negligible Senescence: a comprehensive set of methods to rejuvenate the human body, thereby preventing age-related ill health and mortality. He has co-founded multiple non-profit organizations – including Methuselah Foundation, SENS Research Foundation, and LEV Foundation – to enable and accelerate its development and clinical translation.
The Longevity Escape Velocity Foundation.
_https://www.levf.org/_
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Metaphysic’s new Live tool creates high-resolution photorealistic faceswaps and de-aging effects on top of actors’ performances live and in real-time without the need for further compositing or VFX work.
If we’re going to put an AI brain somewhere, it’s likely going to be a robot. The next step – making that robot immortal.
