Lifeboat Foundation

28 to 34% lifespan increase in mice. I wonder if there would be side effects as a recent study showed Rapamycin and Metformin canceled each other’s side effects.

In a new study published in Aging Cell, researchers have tested several individual drugs and a combination of rapamycin plus acarbose as potential life extension agents in genetically heterogeneous mice [1].

Identification of successful anti-aging interventions is arguably one of the most challenging research problems to date. In addition to the complexity of aging, researchers have to deal with the biological heterogeneity of animals even within the same species and research reproducibility issues due to different experimental designs and approaches.

Continue reading “Combination of Rapamycin and Acarbose Extends Lifespan” »

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Continue reading “Improve Lung Function, Reduce Blood Pressure, Slow Brain Aging?” »

https://www.youtube.com/watch?v=lXTiqZGtnvc&list=PLr-AM3…mp;index=2

Today there might not be a cure to save your life. What if the cure were available tomorrow? Biostasis (cryonics) is a possibility for keeping you around long enough for the cure.

One of the hallmarks of aging, cellular senescence is what happens when aging cells do not die in the usual way (a process known as apoptosis) and start to accumulate in our bodies. The accumulation of these “senescent” cells is implicated in diseases including dementias, atherosclerosis, cancers, diabetes and arthritis. But senescence is not just part of the aging process – it tends to occur in individuals who develop frailty and multiple illnesses, and this can occur at any point during life.

In 2015, a team of researchers at the Mayo Clinic, led by Dr James L Kirkland, published a seminal paper in Aging Cell that introduced a new class of drugs called senolytics. Based on the idea that removing senescent cells may enhance human healthspan, these drugs were identified based on their ability to selectively target and eliminate those cells.

Longevity. Technology: Since the discovery of the first senolytics, hundreds of others have since been identified or created, and senotherapeutics is now one of the hottest areas in longevity, with a host of clinical trials under way and companies pursuing senolytic therapies for a range of age-related conditions. But what does the man who started it all think about the therapeutic field he helped create? In the first of two articles, we bring you Dr Kirkland’s unique perspective on the world of senolytics.

This video is the 1st of a series of “What is Aging” webinars that aims to unravel what aging is, how we age, why we age, and how to reverse it.

We welcome Jason C. Mercurio, MFE, Dr. Jose Cordeiro, and Dr. Ian Hale to discuss the topic.

Continue reading “Aging is a complex, multidimensional, non-linear and widely misunderstood reversible process” »

“The idea was to build a society like we have for all the other disciplines in medicine,” says Evelyne Bischof, a professor of medicine at Shanghai University of Medicine and Health Sciences and the inaugural vice president of the society. She has previously spearheaded educational efforts with Zhavoronkov and others, co-developing a formal course on longevity medicine for doctors. At the ARDD meeting, Bischof announced their course had just received continuing medical education (CME) accreditation from the American Medical Association.

“Longevity medicine is crystallizing as a discipline,” says Andrea Maier, an internal medicine specialist and geriatrician at National University of Singapore who is serving as the society’s inaugural president. One thing that’s not yet clear, several experts told me, is whether longevity will come to be established as a sub-discipline of geriatrics or internal medicine or whether it will become a separate medical specialty unto itself.

“Whichever way it goes,” Maier says, “it’s happening.”

Building A Clinically Credible Platform For Longevity Medicine — Prof. Dr. Andrea Maier MD, PhD, National University of Singapore, Centre for Healthy Longevity.

Professor Dr. Andrea B. Maier, MD, Ph.D., is the Oon Chiew Seng Professor in Medicine, Healthy Ageing and Dementia Research, and Co-Director of the Centre for Healthy Longevity, at the National University Of Singapore (https://discovery.nus.edu.sg/19564-andrea-britta-maier).

Continue reading “Prof. Dr. Andrea B. Maier, MD, PhD — Building A Clinically Credible Platform For Longevity Medicine” »

Just a matter of time for people.

Anti-Aging interview with David Sinclair by Mr. Myllet.

Continue reading “The Aging Process Is Unstoppable, Or Is It…?” »

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Continue reading “BI 103 Randal Koene and Ken Hayworth: The Road to Mind Uploading” »