Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: health – Page 8

1,000-year-old gut microbiome revealed for young man who lived in pre-Hispanic Mexico

Analysis of preserved feces and intestinal tissue has revealed specific types of bacteria that were present in the microbiome of a young adult man who lived in Mexico about 1,000 years ago, prior to Spanish colonization. Santiago Rosas-Plaza of Universidad Nacional Autónoma de México and colleagues present these findings in PLOS One.

The consists of microorganisms, including , that naturally live in people’s intestines. Certain types of bacteria are widely associated with the human gut microbiome, but a person’s particular mix of bacteria may vary depending on factors such as age, diet, health, and where they live. Studying ancient microbiomes using mummies and can therefore deepen understanding of ancient populations and show how the human microbiome may have changed over time.

A growing number of ancient microbiomes have been revealed, including for an ancient Incan person and Germany’s “Tyrolean Iceman.” To further expand the field, Rosas-Plaza and colleagues analyzed the exceptionally well-preserved remains of a man discovered in a in Zimapán, Mexico. Prior analyses suggest the “Zimapán man” was most likely a seasonal seminomadic hunter-gatherer who was part of the ancient Mesoamerican Otopame culture and died about 1,000 years ago between the ages of 21 and 35.

‘Traffic controller’ protein that protects DNA discovered, and it may help kill cancer cells

Mayo Clinic researchers have identified a protein that acts like a traffic controller for DNA, preventing damage during cell division—a discovery that could lead to new cancer therapies, according to a study published in Nature.

“DNA is the code of life. It’s critical for how a cell functions, but it’s also critical for our own being and defines what we are,” says Zhenkun Lou, Ph.D., the Swanson/Schmucker Endowed Professor to Support Health and Cancer Research at Mayo Clinic and the senior author of the new study.

When cells divide, DNA must be copied from one cell to the next—a process called replication. Dr. Lou’s research team discovered that a protein called KCTD10 plays a surprising role in protecting DNA during this critical stage. Acting like a built-in sensor, KCTD10 helps shield the DNA replication from damage.

Alzheimer’s disease research in brain tissue from African American donors points to roles for many novel genes

The prevalence of Alzheimer’s disease (AD) is approximately two times higher in African Americans (AA) compared to white/European-ancestry (EA) individuals living in the U.S. Some of this is due to social determinants of health such as disparities in health care access and quality of education, biases in testing and higher rates of AD risk factors such as cardiovascular disease and diabetes in those who identify as African American.

Although many studies have examined differences in (a measure of the amount of protein encoded by a gene) in from AD cases and controls in EA or mixed ancestry cohorts, the number of AA individuals in these studies was unspecified or too small to identify significant findings within this group alone.

In the largest AD study conducted in brain tissue from AA donors, researchers from Boston University Chobanian & Avedisian School of Medicine have identified many genes, a large portion of which had not previously been implicated in AD by other , to be significantly more or less active in tissue from AD cases compared to controls. The most notable finding was a 1.5 fold higher level of expression of the ADAMTS2 gene in brain tissue from those with autopsy-confirmed AD.

Smart microfibers turn everyday objects into health care monitors and energy devices

New research led by the University of Cambridge, in collaboration with Hong Kong University of Science and Technology (GZ) and Queen Mary University of London, could redefine how we interact with everyday tools and devices—thanks to a novel method for printing ultra-thin conductive microfibers.

Imagine fibers thinner than a human hair (nano-to micro-scale in diameter) that can be tuned on-demand to add sensing, energy conversion and electronic connectivity capabilities to objects of different shapes and surface textures (such as glass, plastic and leather). This is what the researchers have achieved, including in unconventional materials like porous graphene aerogels, unlocking new possibilities for human-machine interaction in various everyday settings.

The researchers present a one-step adaptive fiber deposition process using 3Dprinting, set up to satisfy the fast-changing demands of users. The process enables the on-demand deployment of conductive material layers on different surface areas, dependent on the model’s geometry, at the point of use. The findings are reported in the journal Advanced Fiber Materials.

Sleep patterns linked to variation in health, cognition, lifestyle and brain organization

Researchers led by Aurore Perrault at Concordia University, Canada and Valeria Kebets at McGill University, Canada, have used a complex data-driven analysis to uncover relationships among multiple aspects of sleep and individual variation in health, cognition, and lifestyle.

Published in PLOS Biology, the study reveals five –biopsychosocial profiles and their associated patterns of functional connectivity among brain regions.

Most studies of sleep focus on a single aspect, such as duration, and examine how it relates to a single outcome, like poor mental health. However, trying to understand and predict outcomes by combining the results of many different single-association studies invariably fails. The new study by Perrault and team takes a different approach. Using a sample of 770 people from the Human Connectome Project dataset, they conducted a multivariate, data-driven analysis.

AI-radar system tracks subtle health changes by assessing patient’s walk

Engineering and health researchers at the University of Waterloo have developed a radar and artificial intelligence (AI) system that can monitor multiple people walking in busy hospitals and long-term care facilities to identify possible health issues.

The new technology—housed in a wall-mounted device about the size of a deck of cards—uses AI software and radar hardware to accurately measure how fast each person is walking. A paper on their work, “Non-contact, non-visual, multi-person hallway gait monitoring,” appears in Scientific Reports.

“Walking speed is often called a functional vital sign because even subtle declines can be an early warning of health problems,” said Dr. Hajar Abedi, a former postdoctoral researcher in electrical and computer engineering at Waterloo.

Geomagnetic disturbances caused by sun may influence occurrence of heart attacks, especially among women

An article published in the journal Communications Medicine points to a correlation between disturbances in Earth’s magnetic field resulting from solar storms and an increase in the frequency of heart attacks, especially among women.

The authors reached this conclusion by analyzing data from the public health network of São José dos Campos, in the state of São Paulo, Brazil, recorded between 1998 and 2005, a period considered to be one of intense solar activity.

Focusing on hospital admissions for myocardial infarction, the analysis included information from 871 men and 469 women. Data from the Planetary Index (Kp-Index), an indicator of variations in Earth’s geomagnetic field, were also incorporated into the statistical analysis.

Social threat perceptions in youth linked to altered brain connectivity

Researchers at UCL Institute of Education, King’s College London, Harvard T.H. Chan School of Public Health, and UCLA report that perceived social threats in early adolescence are associated with altered connectivity in default mode, dorsal attention, frontoparietal, and cingulo-opercular networks and with higher mental health symptom scores months later.

Adolescence is a difficult age, a time of rapid neurobiological and psychological change amidst shifting . In 2021, CDC reported that 40% of U.S. struggled with persistent sadness or hopelessness, and more than one in six had made a suicide plan.

Perceived threats in a child’s social environment, within the family, at school, and in the neighborhood, are known risk factors for adolescent psychopathology.

Epigenetic shifts link maternal infection during pregnancy to higher risk of offspring developing schizophrenia

The health of mothers during pregnancy has long been known to play a role in the lifelong mental and physical health of offspring. Recent studies have found that contracting an infection during pregnancy can increase the risk that offspring will develop some neurodevelopmental disorders, conditions that are associated with the atypical maturation of some parts of the brain.

An infection is an invasion of pathogens, such as bacteria, viruses, fungi or parasites, which can then multiply and colonize host tissues. Findings suggest that when an expecting mother contracts an infection, her immune system can respond to it in ways that could impact the development of the fetus.

Researchers at University of Manchester and Manchester Metropolitan University recently carried out a study aimed at further investigating the processes through which maternal infections during pregnancy could increase the risk that offspring will develop schizophrenia later in life. Schizophrenia is a typically debilitating mental health condition characterized by hallucinations, false beliefs about oneself or the world (e.g., delusions) and cognitive impairments.

/* */