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Category: health – Page 2

Pressing pause: A small genetic stop may have helped complex life evolve

Humans have it. So does Drosophila. But not yeast. That “it” is a small pause at the start of gene activity—a brief molecular halt that may have helped life evolve from simple cells to complex animals.

A new study by Charles Danko, associate professor in life science and technology at Cornell’s Baker Institute for Animal Health and in the Department of Biomedical Sciences in the College of Veterinary Medicine, and colleagues explores how this key step in gene regulation—promoter-proximal pausing—evolved across species.

Promoter-proximal pausing occurs just after a cell’s molecular “copy machine”– RNA polymerase II—is activated. The polymerase temporarily stops, usually after about 20 to 60 nucleotides or “letters” of the gene, waiting for further signals.

Online psychoeducation underperforms existing digital cognitive behavioral therapy in trial

Big Health Inc, along with paid academic investigators, reports higher remission rates and lower anxiety symptom scores with their smartphone-delivered digital cognitive behavioral therapy, DaylightRx, compared with an online psychoeducation, also created by Big Health Inc.

Generalized anxiety disorder involves excessive, persistent, and uncontrollable anxiety with lifetime prevalence reported as 6%, alongside reduced quality of life, impaired social and occupational functioning, and increased health care utilization.

Cognitive behavioral therapy and pharmacotherapy are considered first-line treatments. Despite strong tolerability, efficacy, and cost-effectiveness, access remains limited due to a shortage of trained therapists, time burdens, and stigma.

Women are better at recognizing illness in faces compared to men, study finds

Most people have either been told that they don’t look well when they were sick, or thought that someone else looked ill at some point in their lives. People often use nonverbal facial cues, such as drooping eyelids and pale lips, to detect illness in others, potentially to prevent infection in themselves. A new study, published in Evolution and Human Behavior, finds that women are more sensitive to these subtle cues than men.

In past studies, participants have been asked to rate signs of illness in the faces of others, but some of these studies used manipulated photos or people who had artificially induced sicknesses in the photos. In the new study, the team wanted to see whether naturally sick individuals would be rated as sick-looking, or as having an expression of “lassitude,” by other individuals and whether the recognition differed by sex.

To do this, the team recruited 280 undergraduate students, of which 140 were male and 140 were female, to rate 24 photos. The photos consisted of 12 different faces in times of sickness and health.

Why some brains switch gears more efficiently than others

The human brain is constantly processing information that unfolds at different speeds—from split-second reactions to sudden environmental changes to slower, more reflective processes such as understanding context or meaning.

A new study from Rutgers Health, published in Nature Communications, sheds light on how the brain integrates these fast and slow signals across its complex web of white matter connectivity pathways to support cognition and behavior.

Different regions of the brain are specialized for processing information over specific time windows, a property known as intrinsic neural timescales, or INTs for short.

Five ways microplastics may harm your brain

Microplastics could be fueling neurodegenerative diseases like Alzheimer’s and Parkinson’s, with a new study highlighting five ways microplastics can trigger inflammation and damage in the brain.

More than 57 million people live with dementia, and cases of Alzheimer’s and Parkinson’s are projected to rise sharply. The possibility that microplastics could aggravate or accelerate these brain diseases is a major public health concern.

Pharmaceutical scientist Associate Professor Kamal Dua, from the University of Technology Sydney, said it is estimated that adults are consuming 250 grams of microplastics every year—enough to cover a dinner plate.

Thrombolysis With Tenecteplase for Minor Disabling Stroke: Secondary Analysis of the TEMPO-2 Randomized Clinical Trial

A secondary analysis of the TEMPO-2 RCT found no significant improvement in outcomes for minor ischemic stroke patients treated with intravenous tenecteplase, regardless of the presence of disabling deficits.

Question Did outcomes following intravenous tenecteplase for minor ischemic stroke vary based on the presence of disabling deficits?

Findings In this secondary analysis of the TEMPO-2 randomized clinical trial including 884 patients with minor ischemic stroke and proven intracranial occlusion, both patients with and without disabling deficits defined according to US National Institutes of Health Stroke Scale (NIHSS)–based criteria showed a neutral treatment effect from intravenous tenecteplase, with no significant effect modification.

Meaning Current definitions of disabling stroke did not modify the neutral treatment effect of intravenous tenecteplase in patients with minor stroke and intracranial occlusion.

Molecular basis of DNA cross-linking by bacteria

The relevance of the gut microbiome, the community of microorganisms living in the digestive tract, to human health is a topic of intense interest. However, among the numerous benevolent bacteria living in the gut, there are some species that are harmful to humans.

For example, certain strains of Escherichia coli produce the genotoxin colibactin, which causes DNA damage and is linked with colon cancer. However, the colibactin molecule is complex and unstable, which has made it challenging to elucidate its chemical structure and the mechanism by which it damages DNA. In the culmination of years of research from multiple laboratories, researchers in a new Science study reveal the structure of the active form of colibactin bound to DNA.

The findings go a long way toward explaining the mutation signatures associated with colibactin exposure and provide substantial insight into how colibactin contributes to colorectal carcinogenesis.

Learn more in a new Science Perspective.

The structure of the bacterial genotoxin colibactin bound to DNA shows how it might contribute to cancer risk.

Orlando D. Schärer Authors Info & Affiliations

Continue reading “Molecular basis of DNA cross-linking by bacteria” | >

MXene-based e-tattoos harvest energy and monitor health in real time

Researchers at Boise State University have developed a breakthrough in wearable electronics: a multifunctional electronic tattoo (e‑tattoo) that integrates energy harvesting, energy storage, and real‑time biometric sensing into a single, skin‑conformal platform.

The innovation leverages electrospun poly(vinyl butyral‑co‑vinyl alcohol‑co‑vinyl acetate) (PVBVA) fibers coated with titanium carbide (Ti₃C₂Tₓ) MXenes, offering a scalable, biocompatible, and durable alternative to conventional wearable devices that often rely on rigid substrates or external gels.

The work is published in the journal Advanced Science.

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