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Universal Vaccine Blocks Viruses, Bacteria, And Allergies With a Nasal Spray

Imagine getting a nasal spray in the fall months that protects you from all respiratory viruses, including COVID-19, influenza, respiratory syncytial virus, and the common cold, as well as bacterial pneumonia and early spring allergens.


As vital as vaccines are, they can be frustratingly selective about their targets.

Scientists from institutions across the US have now developed a strikingly “universal” vaccine, which has protected mice against a range of viruses, bacteria, and even allergies.

The new GLA-3M-052-LS+OVA vaccine can be delivered as a nasal spray. Three doses protected mice from infection from SARS-CoV-2 and other coronaviruses for three months, and reduced the viral load in their lungs 700-fold, compared to unvaccinated mice.

Encryption: A Key Guardian of Our Digital Future

By Chuck Brooks and Bill Bowers.


Every time you send a text, pay for groceries with your phone, or use your health site, you are relying on encryption. It’s an invisible shield that protects your data from prying eyes. Encryption is more than just a technological protection; it is the basis for digital trust.

Encryption is more than just safeguarding data; it is also about protecting people. It helps ensure privacy by protecting persons from spying and exploitation. And it is widely adopted to help ensure digital transaction security. For National Security it serves to protect key infrastructure and government communications. And it has a human rights function by providing citizens with peace of mind by ensuring the safety of their personal information. In places where surveillance is widespread, encryption can even defend free expression and opposition. It is a human right in this digital age.

In my book Inside Cyber: How AI, 5G, IoT, and Quantum Computing Will Transform Privacy and Security, I referred to encryption as the “linchpin of privacy and commerce in a connected society.” Without it, the digital economy would crumble under the strain of criminality, fraud, and spying.

DHL-11, a novel prieurianin-type limonoid isolated from Munronia henryi, targeting IMPDH2 to inhibit triple-negative breast cancer

Breast cancer destroyed by a plant compound.


Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by the poorest prognosis, and poses a significant threat to women’s health. In this study, we identified two novel prieurianin-type limonoids extracted from Munronia henryi, one of which, named DHL-11, exhibited antitumor activity against TNBC cells. DHL-11 suppressed cell proliferation and migration, induced G2/M cell cycle arrest and apoptosis, and effectively increased the accumulation of reactive oxygen species (ROS) and cellular DNA damage in TNBC cells. Mechanistically, we found that DHL-11 binds to the non-catalytic pocket of IMPDH2 and disrupts the interaction between IMPDH2 and FANCI, leading to the degradation of the IMPDH2 protein. The decrease of IMPDH2 protein reduced guanine synthesis, increased ROS levels, and induced DNA damage.

CISA flags VMware Aria Operations RCE flaw as exploited in attacks

The U.S. Cybersecurity and Infrastructure Security Agency (CISA) has added a VMware Aria Operations vulnerability tracked as CVE-2026–22719 to its Known Exploited Vulnerabilities catalog, flagging the flaw as exploited in attacks.

Broadcom also warned that it is aware of reports indicating the vulnerability is exploited but says it cannot independently confirm the claims.

VMware Aria Operations is an enterprise monitoring platform that helps organizations track the performance and health of servers, networks, and cloud infrastructure.

Abstract: This study challenges the long-standing notion of fibroblasts as passive bystanders in atopic dermatitis

Richard L. Gallo & team discover dermal fibroblasts respond to IL4 and IL13, producing Ccr3-binding chemokines, and driving T cell recruitment in atopic dermatitis:

The figure shows reduction of T cells (red) in an CCR3 antagonist-treated mouse model of atopic dermatitis.


Address correspondence to: Richard L. Gallo, Department of Dermatology, MC0869, UCSD, 9,500 Gilman Dr., La Jolla, California, 92,093, USA. Phone: 858.822.4608; Email: [email protected].

Find articles by Numata, T. in: | Google Scholar |

Department of dermatology, UCSD, la jolla, california, USA.

Does This ED Drug Harm the Retina?

Men with erectile dysfunction (ED) who used sildenafil had a higher risk for serous retinal detachment than those who did not use the drug, a new study finds.

“Our results extend prior claims-based signals of an association between” phosphodiesterase type 5 (PDE5) inhibitors and serous retinal detachment, the researchers reported.


The absence of associations with retinal vascular occlusion and ischemic optic neuropathy suggest sildenafil’s ocular risks may be specific to serous retinal pathology rather than ischemic events affecting the vessels or optic nerve, they wrote.

The study was led by Jaffer Shah of Weill Cornell Medicine in New York City. It was published online on February 21 in Eye.

The use of electronic health records may have introduced residual confounding and misclassification of the use of sildenafil.

SRIC4 Newsletter #04 — What is Quality of Life?

What truly defines “Quality of Life” (QoL), and why we have titled the SRI IV World Congress on it?QoL is a broad concept, including all of the aspects of the life of us, human inhabitants of the third planet of this Solar System. Traditionally, we define QoL through the essentials—food, shelter, health, and education. These are the pillars of economic and cultural development, and they are non-negotiable. Yet, at Space Renaissance, we believe QoL aims higher. It is the freedom to pursue our highest ideals, to have a beautiful life, to explore spirituality, and to seek a global reduction in suffering. Interestingly, the perception of QoL varies wildly across our globe today. The Western post-industrial societies are often clouded by a lack of confidence and a fading hope for what lies ahead. The Eastern emerging societies, fueled by rapid industrial growth, look toward the horizon with immense anticipation. If we could measure QoL through the lens of hope, these emerging societies might actually outrank the West. Why? Because the belief that one is part of a “great project”—one that glorifies human intelligence and potential—is the ultimate antidote to social suffering.

Whether we progress or regress, fall into crisis or rise in a renaissance, it all depends on the mass-psychological mood of the people. When survival is secured, and economic growth creates opportunities for all, social fear dissolves. And as John Lennon famously sang, when fear fades, we finally “give peace a chance.”

We align ourselves with this progressive spirit, like a modern Promethean manifesto. However, we must be realistic: this hope has an expiration date. Without the launch of civil space development by 2030, the “closed world” will inevitably reach its limits. Eastern hopes will be dashed, and Western lifestyles will suffer a sharp decline.

Social Risk Prevalence in AYAs With and Without a History of Cancer

About one-third of adolescents and young adults, with or without Cancer, reported at least one social risk such as financial hardship or food insecurity, highlighting the need for routine screening.


This cross-sectional study used data from KPNW, an integrated health care system serving more than 620 000 members in northwest Oregon and southwest Washington, representing approximately 16% of the region’s population. The KPNW Institutional Review Board deemed the study exempt from review and informed consent under category 4 of the Common Rule, meaning that this research was determined to be low risk as it involves the use of secondary data. The study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline for cross-sectional studies.

Members of KPNW are demographically similar to the surrounding community, with a broad age distribution (approximately 23% aged 18–35 years and 40% aged 36–64 years), a nearly equal sex distribution (52% female), and a racial and ethnic composition comparable to that of the regional population. Approximately 18% of members live below 200% of the federal poverty level, and approximately 80% receive coverage through employer-sponsored plans, contributing to high annual retention rates (approximately 88%). In early 2020, KPNW implemented a social risk screening tool via the EPIC-based (Epic Systems Corp) HealthConnect system. Full details of the screening process have been previously described.22,23

We included KPNW members aged 15 to 40 years who received care at KPNW; completed the social determinants of health screener between January 1, 2022, and December 31, 2024 (the first screening was defined as the index date); and had at least 6 months of follow-up data (eFigure 1 in Supplement 1).

Pearls & Oy-sters: Reversible Leukoencephalopathy and Parkinsonism Due to CNS Involvement in Cryoglobulinemia

What is metabolic dysfunction–associated steatotic liver disease?

Metabolic dysfunction–associated steatotic liver disease (MASLD) involves accumulation of fat in the liver and may progress to liver inflammation and scarring.

The main risk factors for MASLD are obesity and type 2 diabetes.

Usually people with MASLD show no symptoms but some may feel tired or have pain or discomfort in the upper right side of their abdomen.

Eating a low-carbohydrate, low-fat, and low-calorie diet; avoiding alcohol; and exercise are the first-line of treatment for MASLD. sciencenewshighlights ScienceMission https://sciencemission.com/What-Is–MASLD


This JAMA Patient Page describes metabolic dysfunction–associated steatotic liver disease (MASLD) and its risk factors, symptoms and complications, diagnosis, and treatment.

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