Lifeboat Foundation

This is excellent news for Epilepsy.

Epilepsy, a disorder in which nerve cell activity in the brain is disturbed, causing seizures, is the fourth most common neurological problem, following only migraine, stroke and Alzheimer’s. There is no cure for epilepsy, but there are a variety of treatment options. The disease is estimated to affect 2.2 million people in the U.S., with 150,000 people developing the condition each year.

Personalized medicine Scientists at AES discussed how new technologies, such as gene editing using CRISPR-Cas9, and next-generation sequencing, are empowering them to take a new crack at the human genome and find new ways to diagnose and treat epilepsy.

Continue reading “Genomics, Cannabidiols Drive Epilepsy Research” »

With a decision imminent on permitting UK gene-editing research using human embryos, New Scientist explains the potential pay-off and limitations of the work.

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This is an interesting conjecture.

We may be able to keep our gut in check after all. That’s the tantalizing finding from a new study published today that reveals a way that mice—and potentially humans—can control the makeup and behavior of their gut microbiome. Such a prospect upends the popular notion that the complex ecosystem of germs residing in our guts essentially acts as our puppet master, altering brain biochemistry even as it tends to our immune system, wards off infection and helps us break down our supersized burger and fries.

In a series of elaborate experiments researchers from Harvard Medical School and Brigham and Women’s Hospital discovered that mouse poop is chock full of tiny, noncoding RNAs called microRNAs from their gastrointestinal (GI) tracts and that these biomolecules appear to shape and regulate the microbiome. “We’ve known about how microbes can influence your health for a few years now and in a way we’ve always suspected it’s a two-way process, but never really pinned it down that well,” says Tim Spector, a professor of genetic epidemiology at King’s College London, not involved with the new study. “This [new work] explains quite nicely the two-way interaction between microbes and us, and it shows the relationship going the other way—which is fascinating,” says Spector, author of The Diet Myth: Why the Secret to Health and Weight Loss Is Already in Your Gut.

Continue reading “Does our Microbiome Control Us or Do We Control It?” »

Early detection by Grail (leveraging illumina’s gene sequencing technology) looks promising. This truly will be beneficial for early detection. And, I will be very interested in seeing how it benefits those who are genetically pre-disposed to cancer related gene mutations especially around Esaphogus, Glioblastoma, and Pancreatic cancers since these are often hard to detect in their earliest stages.

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Wow — now, I know who to blame for my hay fever allergy.

If you want someone to thank for your immunity to a whole host of pathogens — or, someone to blame for your allergies — look no further than Neanderthals.

Humans carry three important genes that hail from two ancient, human-like species: Neanderthals and Denisovans, both of which have been extinct for tens of thousands of years.

Continue reading “Neanderthals may be to blame for your allergies” »

Dr Millers paper here hits the nail on the head for me about aging research and how we can speed it up.

“The time spent by gerontologists debating whether aging is a single process or many would be better devoted to trying to figure out the mechanistic links between the master clock whose existence is strongly suggested by the unitarian argument and the many cell-specific, organ-specific, and organism-wide processes that march in crude synchrony at species-specific rates.”

Yes! This is exactly the attitude to take. Too much debate and argument instead of buckling down and getting the research done to prove or disprove aging hypotheses. Cut to the chase and lets just do it.

Continue reading “The historical assumption has been that, human aging is a natural process, and one that is non optional with regard to medical interventions” »

Zoltan Istvan, you re in the Daily Mail.

California-based, Zoltan Istvan, is leader of the Transhumanst party, and believes that mind uploading, cyborg body augmentation, and genetic manipulation could help us live forever.

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https://soundcloud.com/kelly-tang-9/sets/nasa-sounds-of-earth

“Programming ‘indestructible’ bacteria to write poetry.”

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At one time or another, we’ve all been encouraged to “maximize our potential.” In a recent interview, Academic and Entrepreneur Juan Enriquez said that mankind is making progress toward expanding beyond its potential. And the changes, he believes, could be profound.

To illustrate the process, Enriquez theorized what might happen if we were to bring Charles Darwin back to life and drop him in the middle of Trafalgar Square. As Darwin takes out his notebook and starts observing, Enriquez suggested he would likely see what might appear to be a different species. Since Darwin’s time, humans have grown taller, and with 1.5 billion obese people, larger. Darwin might also notice some other features too that many of us take for granted — there are more senior citizens, more people with all their teeth, a lot fewer wrinkles, and even some 70-year-olds running in marathons.

“There’s a whole series of morphologies that are just different about our bodies, but we don’t notice it. We don’t notice we’ve doubled the lifespan of humans in the last century,” Enriquez said. “We don’t notice how many more informations (sic) come into a brain in a single day versus what used to come in in a lifetime. So, across almost every part of humanity, there have been huge changes.”

Part of the difference that Darwin would see, Enriquez noted, is that natural selection no longer applies as strongly to life and death as it once did. Further, random gene mutations that led to some advantages kept getting passed down to generations and became part of the species. The largest difference, however, is our ongoing move toward intelligent design, he said.

Continue reading “Can We Evolve Ourselves To Expand Beyond Human Potential?” »