Lifeboat Foundation

To help reduce this problem, Evitria says they’ve licensed Lonza’s bYlok^® technology to improve light chain pairing. The starting point involves antibodies with a “knob” or a “hole” in the heavy chains, so-called “knobs-into-holes” technology, to help improve correct bonding between parts of the bispecific, Schmidt explained.

“What you have are two variations, bYlok and non-loked, and another two combinations where one chain has a hole formation and the other a knob formation and vice versa,” he says. “And you can express these four combinations to see the impact of the expression level, the yields, heterodimer formation, and purity.”

By doing this early screening, he adds, it’s possible for customers to speed up their process development and move to commercial bsAb manufacturing.

Ancient cultures long thought the Sun had a mind of it’s own, but could life form in stars by nature or exist by artificial origins, and what would star with a mind of its own be like?

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Continue reading “Living Stars & Conscious Stellar Objects” »

Bifurcation parameter is a root point of period-2ⁿ component. This series converges to the Feigenbaum point c = −1.401155… The ratio in the last column converges to the first Feigenbaum constant.

“Lake Enigma” is living up to its name.

By measuring the melting temperature of iron under high transient pressure, researchers set a limit on the temperature at the boundary between the inner and outer cores.

We often imagine that our planet might be a sentient entity — Gaia — but could something like this evolve under known science? And might a conscious world be something we might create in the future?

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Continue reading “Sentient Planets & World Consciousnesses” »

Diving deep into the relationship between a concept’s frequency in the training dataset and the ability of a model to imitate it. We seek to determine the point at which a model was trained on enough instances to imitate a concept — the imitation threshold.

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Physicist, futurist, bestselling author, popularizer of science.