Reprogramming without having to insert genes.
When people think of cellular reprogramming, converting a differentiated cell into a stem cell, they often refer to the overexpression of Yamanaka factors[Oct4, Klf4, Sox2 & c-Myc]. Rightly so. But what if i told you that stem cells could be induced with just chemicals. Well you would reply “show me the data”. So, let’s take a look at this recent Nature paper that showed how combinations of small molecules/chemicals converted human differentiated cells to stem cells.
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