Lifeboat Foundation

I have created an educational guide to the adenovirus capsid! The adenovirus is one of the most frequently used types of viruses for gene therapy (along with AAV and lentivirus). It is a powerful vehicle for delivering DNA to cells in the body. But to work with adenovirus as a technology, it is important to understand its fundamental biological structure and function. This guide will help you to gain a more holistic comprehension of a particularly important part of adenovirus biology: the capsid. I made the images using PyMol.

PDF version: Guide to the Structure and Function of the Adenovirus Capsid

For this guide, I will explain the fundamental biology of adenovirus capsid proteins with an emphasis on the context of gene therapy. While the guide is meant primarily for readers with an interest in applying adenovirus to gene therapy, it will not include much discussion of the techniques and technologies involved in engineering adenoviruses for such purposes. If you are interested in learning more about adenovirus engineering, you may enjoy my review paper “Synthetic Biology Approaches for Engineering Next-Generation Adenoviral Gene Therapies” [1]. Here, I will focus mostly on the capsid of human adenovirus serotype 5 (Ad5) since it is the most commonly used type of adenovirus employed in gene therapy research, but I will occasionally describe other types of adenoviruses when necessary. Many of the presented concepts remain the same or similar across other types of adenoviruses.

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Thomas Fuller, an African sold into slavery in 1,724 at age 14, was sometimes known as the “Virginia Calculator” for his extraordinary ability to solve complex mathematical problems in his head. He was asked how many seconds there were in a year, he briefly answered 31,536,000 seconds.

He was asked again how many seconds a man who is 70 years old, 17 days and 12 hours lived, he answered in a minute and a half 2,210,500,800. One of the men was doing the problems on paper and informed Fuller that he was wrong because the answer was much smaller. Fuller hastily responded, “Nah, you forgot about leap years. When leap years were added to the account, the sums matched up.”

Fuller was one of the first cases recorded in the literature of the wise man syndrome, when in 1,789, Benjamin Rush, the father of American psychiatry, described his incredible ability to calculate, without having an education and training in mathematics, his ability was used as proof that enslaved African Americans were equal to whites in intelligence, fueling some pro-abolitionist discussions.

US-based architecture studio NBBJ has released designs for a net-zero school in Encino, California, that will cater to neurodiverse students.

The design of the Lower School campus of Westmark School uses acoustic technologies, as well as the integration of flora and natural materials, to create a comfortable environment for students with special needs.

“Designers selected a variety of sound-absorbing materials for different spaces, developed reading nooks and other niches for creative learning both inside and outside the classroom, and oriented views to green space to enhance different educational modes,” said NBBJ.

What’s on their curriculum? Organic farming, aquaculture and lots more.

The failures of One Laptop per Child have much to teach us about fixing educational inequities.

Remote robotic-assisted surgery is far from new, with various educational and research institutions developing machines doctors can control from other locations over the years. There hasn’t been a lot of movement on that front when it comes to endovascular treatments for stroke patients, which is why a team of MIT engineers has been developing a telerobotic system surgeons can use over the past few years. The team, which has published its paper in Science Robotics, has now presented a robotic arm that doctors can control remotely using a modified joystick to treat stroke patients.

That arm has a magnet attached to its wrist, and surgeons can adjust its orientation to guide a magnetic wire through the patient’s arteries and vessels in order to remove blood clots in their brain. Similar to in-person procedures, surgeons will have to rely on live imaging to get to the blood clot, except the machine will allow them to treat patients not physically in the room with them.

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By Ingemar Patrick Linden

A philosopher refutes our culturally embedded acceptance of death, arguing instead for the desirability of anti-aging science and radical life extension.

Ingemar Patrick Linden’s central claim is that death is evil. In this first comprehensive refutation of the most common arguments in favor of human mortality, he writes passionately in favor of antiaging science and radical life extension. We may be on the cusp of a new human condition where scientists seek to break through the arbitrarily set age limit of human existence to address aging as an illness that can be cured. The book, however, is not about the science and technology of life extension but whether we should want more life. For Linden, the answer is a loud and clear “yes.”

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To fully embrace the benefits of quantum computing in the future, we need to focus on education and workforce development and become quantum-ready today.

The 13-year-old daughter of a friend visiting my workplace — the IBM Research lab in Zurich — seemed puzzled. She knew I worked in a research lab and I that work with computers, but the computers she knows don’t typically resemble the chandelier-like structure that hung from the ceiling in front of us.

Yet, it is a computer – a quantum computer. And while someone in their early teens right now can be excused for not knowing what a quantum computer is, I would very much like that to change.

Watch the full documentary on TUBI (free w/ads):
https://tubitv.com/movies/613341/consciousness-evolution-of-the-mind.

IMDb-accredited film, rated TV-PG
Director: Alex Vikoulov.
Narrator: Forrest Hansen.
Copyright © 2021 Ecstadelic Media Group, Burlingame, California, USA

Continue reading “Towards The Cybernetic Theory of Mind | Part V of Consciousness: Evolution of the Mind Documentary” »