CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg have expanded this extensive toolbox. Their novel method, called PUMA, enables the detection of RNA with Cas12 nucleases, which naturally target DNA. PUMA promises a wide range of applications and high accuracy.
The team published its results in the journal Nature Communications (“TracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases”).
Bacteria have developed special defense mechanisms to protect themselves against viruses, which by no means infect only humans. As part of these so-called CRISPR-Cas systems, a CRISPR ribonucleic acid (crRNA), which serves as a “guide RNA,” recognizes regions of a foreign genome, such as viral DNA. The CRISPR-associated (Cas) nuclease, directed by a crRNA, then renders it harmless by cutting it like a pair of scissors.
Proposed lunar biorepository could store genetic samples without electricity or liquid nitrogen. New research led by scientists at the Smithsonian proposes a plan to safeguard Earth’s imperiled biodiversity by cryogenically preserving biological material on the moon. The moon’s permanently shadowed craters are cold enough for cryogenic preservation without the need for electricity or liquid nitrogen, according to the researchers.
The paper, published today in BioScience and written in collaboration with researchers from the Smithsonian’s National Zoo and Conservation Biology Institute (NZCBI), Smithsonian’s National Museum of Natural History, Smithsonian’s National Air and Space Museum and others, outlines a roadmap to create a lunar biorepository, including ideas for governance, the types of biological material to be stored and a plan for experiments to understand and address challenges such as radiation and microgravity. The study also demonstrates the successful cryopreservation of skin samples from a fish, which are now stored at the National Museum of Natural History.
“Initially, a lunar biorepository would target the most at-risk species on Earth today, but our ultimate goal would be to cryopreserve most species on Earth,” said Mary Hagedorn, a research cryobiologist at NZCBI and lead author of the paper. “We hope that by sharing our vision, our group can find additional partners to expand the conversation, discuss threats and opportunities and conduct the necessary research and testing to make this biorepository a reality.”
Robert J. Sternberg has devoted much of his career to the study of various conceptions of human intelligence. Starting with his Triarchic Theory of Human Intelligence (Sternberg, 1985), he has expanded on his view of human ability and success. Successful intelligence is defined as that set of mental abilities used to achieve one’s goals in life, given a socio-cultural context, through adaptation to, selection of, and shaping of environments. Successful intelligence involves three aspects that are interrelated but largely distinct: analytical, creative, and practical thinking (Sternberg, 1998). Practical Intelligence is the ability to size up a situation well, to be able to determine how to achieve goals, to display awareness to the world around you, and to display interest in the world at large (Sternberg, 1990; Sternberg et al., 2000; Wagner, 2000). Prof. Sternberg is working on several projects that examine the interrelation of his various conceptions of ability in applied settings.
Sternberg has proposed what he refers to as a “triarchic theory” of human intelligence.14 The original version of the theory is triarchic in that it argues that intelligence comprises three sets of skills: creative, analytical, and practical. In its augmented version, it specifies the importance of wisdom-based skills as well. According to this theory, people are intelligent in their lives to the extent that they: (i) formulate and achieve goals that help them attain what they seek in life, given their cultural context; (ii) by capitalizing on their strengths and compensating for or correcting weaknesses; (iii) in order to adapt to, shape, and select environments; (iv) through a combination of essential skills. As mentioned above, the essential skills are: (i) creative skills to generate novel ideas; (ii) analytical skills in order to assure that the ideas are good ones; (iii) practical skills in order to implement their ideas and persuade others of their value; and (iv) wisdom-based skills in order to ensure that the ideas help to achieve a common good over the long as well as the short term through the infusion of positive ethical values.
The various aspects of the theory—analytical, creative, practical, wisdom—are measurable. Sternberg has shown that when they are measured, they improve prediction of both academic and nonacademic performance in university settings and reduce ethnic-group differences.15 Teaching that incorporates the various aspects of intelligence Increases academic performance relative to conventional teaching.16 Sternberg has argued that intelligence is at least somewhat malleable throughout the lifespan.
While generative AI tools have been heralded as the future of education, more than 40 years of academic research suggests that it could also harm learning in realms from online tutoring to employee training for three reasons. First, the best student-teacher relationships are empathetic ones but it is biologically impossible for humans and AI to develop mutual empathy. Second, AI might help us bypass the boring task of knowledge accumulation but it is only through that process that we develop higher order thinking skills. Finally, digital tools are notoriously distracting and multitasking diminishes learning. As we think about the benefits of new technology, we must also consider the risks.
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Three fundamental problems with using LLMs as teachers, tutors, and trainers.
While AI has the potential to automate many tasks, there are certain jobs that require human skills and abilities that AI cannot replicate. These include jobs that require creativity, empathy, critical thinking, and human interaction. According to the World Economic Forum, AI is unlikely to be able to replace jobs requiring human skills such as judgement, creativity, physical dexterity and emotional intelligence. Some examples of jobs that AI cannot replace include psychologists, caregivers, most engineers, human resource managers, marketing strategists, and lawyers. In this video, Dr. Michio Kaku mentioned three specific types of jobs that AI cannot replace: blue-collar jobs that are not repetitive, emotional jobs, and jobs requiring imagination. These types of jobs require human skills and abilities that are difficult for AI to replicate. For example, blue-collar jobs that are not repetitive often require physical dexterity and mobility. Emotional jobs require empathy and the ability to connect with others on a personal level. Jobs requiring imagination involve creativity and innovation. In conclusion, while AI has the potential to automate many tasks and change the job landscape, there are certain jobs that require human skills and abilities that AI cannot replicate. These include blue-collar jobs that are not repetitive, emotional jobs, and jobs requiring imagination. It is important for individuals to develop these skills in order to thrive in the future job market. Fair Use Disclaimer : Copyright disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, commenting, news reporting, teaching, scholarship and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. Disclaimer: The video and audio content used in this video is for educational purposes only and does not belong to me. I have given credit to the respective owners and creators of the content. This video is intended to provide information and knowledge to its viewers, and no copyright infringement is intended. I have made every effort to ensure that the content used in this video is properly credited and used in accordance with fair use guidelines. If you are the owner of any content used in this video and have any concerns, please contact me. Legal Disclaimer : The video clips incorporated into this project are the sole property of their respective owners and creators. I do not claim ownership or rights to any of the content used. All credit is attributed to the original sources. No copyright infringement is intended. Clips Provided by Cuckoo for Kaku Watch : https://youtu.be/JANGUKLJkPQ #shorts #shortsfeed #shortvideos #shortvideo #shortsvideo #shortsyoutube #shortsviral #viralshortsvideo #viralshorts #viral #viralvideo #viralvideos #space #spaceflightsimulator #deepspace #spaceship #spacelovers #spacesuit #spaceexploration #spacecraft #telescope #spacex #spacestation #universe #cosmos #nasa #viral #viralvideo #viralvideos #science #technology #physics #astronomy #astrophysics #astrophotography #cosmology #cosmos #jwst #jameswebbspacetelescope #jameswebb #hubble #hubbletelescope #video #videos #interstellar
This is because the species undergoes a process called polyploidization, which is when a single chromosome is duplicated multiple times.
“It has amazing genetic diversity,” study co-author Tim O’Hara, a senior marine curator at Museums Victoria in Australia, told Newsweek.
“Instead of evolving into separate species over time, lineages readily hybridize with each other, so building up a great amount of genetic diversity. But not only that, they sometimes add their genomes together, so end up with four or more copies of each gene,” O’Hara said.
Mental effort is generally unpleasant, as confirmed by a meta-analysis involving over 4,600 participants across various tasks and demographics. People often pursue challenging activities for the rewards, not the pleasure of the task. Credit: SciTechDaily.com.
A meta-analysis of 170 studies revealed that regardless of the task or population, increased mental effort correlates with feelings of frustration and stress. This phenomenon is less pronounced in Asian populations, possibly due to different educational experiences. Despite this, people still engage in mentally challenging tasks like chess, driven by the rewards rather than enjoyment of the effort itself.
There’s only one alliterative phrase i like more than ‘the sheekey science show’, and that’s ‘anti-aging antibodies’. now, as it happens, one thing i spent a lot of time working on this year is antibodies. Antibody, make me feel this way. now while i cannot tell you yet what i was/am doing, i can tell you about two recent science stories that exploit antibodies to extend mouse lifespan. Firstly, i will bring your attention to this paper — immunotherapy targeting isoDGR-protein damage extends lifespan and then we’ll look at this paper that came out last month — Inhibition of IL-11 signalling extends mammalian healthspan.
Equitable and accessible education in life sciences, bioengineering, and synthetic biology is crucial for training the next generation of scientists. Here the authors present the CRISPRkit, a cost-effective educational tool that enables high school students to perform CRISPR experiments affordably and safely without prior experience, using smartphone-based quantification and an automated algorithm for data analysis.
