Lifeboat Foundation

Artificial intelligence start-ups are making revenues more quickly than previous waves of software companies, according to new data that suggests that the transformative technology is also generating strong businesses at an unprecedented rate.

According to an analysis of payments information from fintech group Stripe, top AI groups are reaching millions of dollars in sales within a year — far faster in a start-up’s life cycle than comparable non-AI tech groups.

The findings come as investors raise questions about the economic benefits of generative AI and likely returns on Big Tech’s projected trillion-dollar investment in computing infrastructure to support the technology over the coming year.

The SARS-CoV-2 pandemic has had an unprecedented impact on global public health and the economy. Although vaccines and antivirals have provided effective protection and treatment, the development of new small molecule-based antiviral candidates is imperative to improve clinical outcomes against SARS-CoV-2. In this study, we identified UNI418, a dual PIKfyve and PIP5K1C inhibitor, as a new chemical agent that inhibits SARS-CoV-2 entry into host cells. UNI418 inhibited the proteolytic activation of cathepsins, which is regulated by PIKfyve, resulting in the inhibition of cathepsin L-dependent proteolytic cleavage of the SARS-CoV-2 spike protein into its mature form, a critical step for viral endosomal escape. We also demonstrated that UNI418 prevented ACE2-mediated endocytosis of the virus via PIP5K1C inhibition. Our results identified PIKfyve and PIP5K1C as potential antiviral targets and UNI418 as a putative therapeutic compound against SARS-CoV-2.

Despite the ongoing threat posed by new viruses following the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which led to the coronavirus disease 2019 (COVID-19) pandemic, new antiviral drugs continue to be developed to effectively block viral entry into the human body.

Professor Kyungjae Myung and his research team in the Department of Biomedical Engineering, affiliated with the IBS Center for Genomic Integrity, has discovered UNI418, a compound that effectively prevents the penetration of the coronavirus. This compound works by regulating dielectric homeostasis, thereby inhibiting the virus’s entry into human cells.

A small-N comparative analysis of six different areas of applied artificial intelligence (AI) suggests that the next period of development will require a merging of narrow-AI and strong-AI approaches. This will be necessary as programmers seek to move beyond developing narrowly defined tools to developing software agents capable of acting independently in complex environments. The present stage of artificial intelligence development is propitious for this because of the exponential increases in computer power and in available data streams over the last 25 years, and because of better understanding of the complex logic of intelligence. Applied areas chosen for examination were heart pacemakers, socialist economic planning, computer-based trading, self-driving automobiles, surveillance and sousveillance and artificial intelligence in medicine.

AI may equal human intelligence without matching the true nature of our experiences.

By Christof Koch

A future where the thinking capabilities of computers approach our own is quickly coming into view. We feel ever more powerful machine-learning (ML) algorithms breathing down our necks. Rapid progress in coming decades will bring about machines with human-level intelligence capable of speech and reasoning, with a myriad of contributions to economics, politics and, inevitably, warcraft. The birth of true artificial intelligence will profoundly affect humankind’s future, including whether it has one.

11 likes, — cyberserge on June 20, 2024: Universal Basic income for the unemployed.

#AI #income #future #work #belong #meaning #personaldevelopment #personaltrainer

Data from tangential flow filtration experiments using cell culture medium without animal products are used to estimate the costs of scaled-up, continuous cultivated chicken manufacturing.

A team led by scientists at the Department of Energy’s Oak Ridge National Laboratory identified and successfully demonstrated a new method to process a plant-based material called nanocellulose that reduced energy needs by a whopping 21%. The approach was discovered using molecular simulations run on the lab’s supercomputers, followed by pilot testing and analysis.

The method, leveraging a solvent of sodium hydroxide and urea in water, can significantly lower the production cost of nanocellulosic fiber — a strong, lightweight biomaterial ideal as a composite for 3D-printing structures such as sustainable housing and vehicle assemblies. The findings support the development of a circular bioeconomy in which renewable, biodegradable materials replace petroleum-based resources, decarbonizing the economy and reducing waste.

Colleagues at ORNL, the University of Tennessee, Knoxville, and the University of Maine’s Process Development Center collaborated on the project that targets a more efficient method of producing a highly desirable material. Nanocellulose is a form of the natural polymer cellulose found in plant cell walls that is up to eight times stronger than steel.

With mechanical recycling, “if you mix the sandwich bag and the milk jug together and then try to remake an object from that, you can’t make a very good milk jug and you can’t make a very good sandwich bag,” he said. “We’re trying to bring the plastics back to the chemicals from which they’re made in the first place,” Hartwig said.

The researchers use a catalyst, a component of a chemical reaction that makes it go faster, to vaporize both polyethylene and polypropylene plastics — two of the largest volumes of plastics in existence — transforming the solid waste into gases.

The polymers are reduced to their chemical precursors, which can then be reconstructed. In a press release, the university said the process brings “a circular economy for plastics one step closer to reality.”

China’s investment is driven by a need to secure a stable supply of chips critical to various industries, which is why over a dozen Chinese fabs are coming online in 2024 and 2025. Therefore, this surge in spending is not limited to the country’s top-tier manufacturers, such as Semiconductor Manufacturing International Corp. (SMIC) and Hua Hong, but also includes significant contributions from smaller and mid-sized chipmakers. These investments enabled China to maintain its position as the world’s largest market for chipmaking equipment. Virtually all new Chinese fabs are focused on trailing nodes, as it is hard for Chinese companies to get the advanced tools required to make chips on leading-edge process technologies.

China is the only major market to increase its spending on fab tools compared to the previous year despite a global economic slowdown. In contrast, Taiwan, South Korea, and North America all reduced their investments in wafer fab equipment during the same period.

The spending surge in China has also significantly impacted chipmaking tool makers. Companies like Applied Materials, Lam Research, KLA from the U.S., Tokyo Electron from Japan, and ASML from the Netherlands have all reported increased revenue contributions from Chinese companies. Such contributions range from 32% at Applied to 49% at ASML.