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Category: chemistry – Page 27

Anti-neuroinflammatory natural products from isopod-related fungus now accessible via chemical synthesis

“Herpotrichone” is a natural substance that has been evaluated highly for its excellent ability to suppress inflammation in the brain and protect nerve cells, displaying significant potential to be developed as a therapeutic agent for neurodegenerative brain diseases such as Alzheimer’s disease and Parkinson’s disease. This substance could only be obtained in minute quantities from fungi that are symbiotic with isopods. However, KAIST researchers have succeeded in chemically synthesizing this rare natural product, thereby presenting the possibility for the development of next-generation drugs for neurodegenerative diseases.

A research team led by Professor Sunkyu Han of the Department of Chemistry successfully synthesized the natural anti-neuroinflammatory substances ‘herpotrichones A, B, and C’ for the first time. The paper is published in the Journal of the American Chemical Society.

Herpotrichone natural products are substances obtainable only in minute quantities from Herpotrichia sp. SF09, a symbiotic pill bug fungus, and possesses a unique 6÷6÷6÷6÷3 pentacyclic framework consisting of five fused rings (four six-membered and one three-membered ring).

Cosmic Rays May Be Fueling Hidden Life on Mars and Beyond

“This discovery changes the way we think about where life might exist,” said Atri. “Instead of looking only for warm planets with sunlight, we can now consider places that are cold and dark, as long as they have some water beneath the surface and are exposed to cosmic rays. Life might be able to survive in more places than we ever imagined.”

The study introduces a new idea called the Radiolytic Habitable Zone. Unlike the traditional “Goldilocks Zone” — the area around a star where a planet could have liquid water on its surface — this new zone focuses on places where water exists underground and can be energized by cosmic radiation. Since cosmic rays are found throughout space, this could mean there are many more places in the universe where life could exist.

The findings provide new guidance for future space missions. Instead of only looking for signs of life on the surface, scientists might also explore underground environments on Mars and the icy moons, using tools that can detect chemical energy created by cosmic radiation.

Experiment Recreates The Universe’s Very First Chemical Reactions

The first chemical reactions in the wake of the Big Bang have been recreated for the first time in conditions similar to those in the baby Universe.

A team of physicists led by Florian Grussie of the Max Planck Institute for Nuclear Physics (MPIK) in Germany has reproduced the reactions of the helium hydride ion (HeH+), a molecule made from a neutral helium atom fusing with an ionized atom of hydrogen.

These are the first steps that lead to the formation of molecular hydrogen (H2), the most abundant molecule in the Universe and the stuff from which stars are born. The new work, therefore, elucidates some of the earliest processes that gave rise to the Universe as we know it today.

New Technique Sheds Light on Chemistry at the Bottom of the Periodic Table

The periodic table is one of the triumphs of science. Even before certain elements had been discovered, this chart could successfully predict their masses, densities, how they would link up with other elements, and a host of other properties.

But at the bottom of the periodic table, where massive atoms are practically bursting at the seams with protons, its predictive power might start to break down. Experiments to study the chemistry of the heaviest elements — especially the superheavy elements, which have more than 103 protons — have long been a challenge. Despite using specialized facilities, researchers have been unable to definitively identify the molecular species they produce in experiments. This uncertainty has hindered progress in the field, since scientists have had to rely on educated guesses rather than precise knowledge of the chemistry being observed.

Now, researchers have used the 88-Inch Cyclotron at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) to develop a new technique to make and directly detect molecules containing heavy and superheavy elements. In a study published today in the journal Nature, a team of researchers from Berkeley Lab, UC Berkeley, and The University of Alabama used the method to create molecules containing nobelium, element 102. It is the first time scientists have directly measured a molecule containing an element greater than 99.

Nobel Prize in Chemistry Awarded for Breakthrough “Click Chemistry” Discoveries

The 2022 Nobel Prize in Chemistry was awarded to Carolyn Bertozzi, K. Barry Sharpless, and Morten Meldal for pioneering the development of “click chemistry.” The trio will share a prize amounting to ten million Swedish kronor, approximately 925,000 euros.

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Solving a 13-Billion-Year-Old Mystery: Scientists Recreate the Universe’s First Chemical Reaction

Researchers have uncovered new insights into the reaction pathways of the universe’s first molecule. Shortly after the Big Bang, which took place around 13.8 billion years ago, the universe was a seething, dense expanse of extreme heat. In just a matter of seconds, it began to cool enough for the f

Tracing brain chemistry across humanity’s family tree

The evolutionary success of our species may have hinged on minute changes to our brain biochemistry after we diverged from the lineage leading to Neanderthals and Denisovans about half a million years ago.

Two of these tiny changes that set modern humans apart from Neanderthals and Denisovans affect the stability and genetic expression of the adenylosuccinate lyase, or ADSL. This enzyme is involved in the biosynthesis of purine, one of the fundamental building blocks of DNA, RNA, and other important biomolecules.

In a study published in PNAS, researchers from the Okinawa Institute of Science and Technology (OIST), Japan and the Max Planck Institute for Evolutionary Anthropology, Germany have discovered that these changes may play an important role in our behavior, contributing new pieces to the great puzzle of who we humans are and where we come from.

Altered protein translation elongation contributes to brain aging

The GFP gene, which has its origins in jellyfish, expresses proteins that fluoresce when illuminated with certain frequencies of light. Poeschla, of the Mayo Clinic in Rochester, Minnesota, reported his results in the journal Nature Methods.

This function is regularly used by scientists to monitor the activity of individual genes or cells in a wide variety of animals. The development and refinement of the GFP technique earned its scientific pioneers the Nobel prize for chemistry in 2008.

In the case of the glowing cats, the scientists hope to use the GM animals in the study of HIV/AIDS.

In vitro anti-cancer efficacy and phyto-chemical screening of solvent extracts of Kigelia africana (Lam.) Benth

Kigelia africana is a medicinal plant growing naturally in many parts of Africa. In Kenya, a water concoction of the plant is used to treat breast and prostate cancers. Laboratory data on its anti-cancer activity and active principles is limited, hence no scientific rationale for its medicinal use. This study reports on in-vitro toxic activities of dichloromethane and methanol extracts of the plant against human breast cancer cells and phytochemical screening of the two extracts.

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