Magnetic resonance imaging (MRI) has long been a cornerstone of modern medicine, providing highly detailed images of internal organs and tissues. MRI machines, those large, tube-shaped magnets commonly found in hospitals, use powerful magnets to map the densities of water and fat molecules within the body.
Researchers from the Department of Energy’s Oak Ridge National Laboratory have taken a major step forward in using quantum mechanics to enhance sensing devices, a new advancement that could be used in a wide range of areas, including materials characterization, improved imaging and biological and medical applications.
Neural microtissues derived from pluripotent stem cells (iPSCs) can replace dopaminergic neurons, the nerve cells that are lost in Parkinson’s disease, and restore motor function when grown into tiny capsules and transplanted into the brains of model rats, a study led by TreeFrog Therapeutics found.
“TreeFrog Therapeutics has overcome the most complex challenges of developing a successful treatment for Parkinson’s disease using our C-Stem platform technology and producing a therapy containing mature dopaminergic neurons with a unique 3D format that promotes cell survival post-graft with proven pre-clinical results,” Jens Schroeder, MD, PhD, TreeFrog’s chief medical officer, said in a company press release.
The study, “Bioreactor-produced iPSCs-derived dopaminergic neuron-containing neural microtissues innervate and normalize rotational bias in a dose-dependent manner in a Parkinson rat model,” was published in Neurotherapeutics.
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A new study has found that the gene therapy COG-201, delivered through a nasal spray, can improve memory and decrease anxiety in animal models, offering a new approach to treating neurological conditions.
Innovative research from Vilnius University sheds light on how DNA methylation impacts cellular aging and healthspan.
Genetic testing company settles with plaintiffs over breach that was revealed when hacker published link to database labeled ‘ashkenazi DNA Data of Celebrities’
The breach, which occurred last October, affected more than 6.9 million customers and included users’ personal details such as their location, name and birthdate, as well as some information about their family trees. That data was shared on BreachForums, an online forum used by cybercriminals.
According to court documents, the data breach was revealed October 6 after a hacker going by the pseudonym Golem, a reference to the Jewish mythical defender made of clay, published a link to a database labeled ashkenazi DNA Data of Celebrities. According to the lawsuit, the hacker referred to the list as the most valuable data you’ll ever see, though most of the names were not famous.
Expanding Healthy Human Lifespan for All — Dr. Mehmood Khan, MD — CEO, Hevolution Foundation.
Dr. Mehmood Khan, MD is the Chief Executive Officer of Hevolution Foundation (https://www.hevolution.com/), a first of its kind non-profit organization that funds research through grants and provides investments in biotech to incentivize healthspan science across disciplines and borders for the benefit of all. Established by a Saudi Royal Decree, with its headquarters in Riyadh, with additional international hubs to support the expansion and execute the global mission, it’s vision is to expand healthy human lifespan for the benefit of all humanity.
https://youtube.com/channel/UC8Gtb6QcDOTbwcsDJo1bcGg
This little boy is really smart. I’m like in my 50’s this kid is barely 10, but much smarter than I am. Share and show him support. We need to have incentives for kids to thrive educationally. Props to the kids parents, they really raised an inspirational talent.
Sean is an aspiring brain and heart surgeon and he has created a name for it. He wants to be a “Neurocardio surgeon”. A word he created from Neurologist and Cardiologist. He is a STEM Educator Education Promotor/Advocate. He loves to learn and teach and wants to make the learning of science fun for all. Sean wants to create the awareness that science is not complex and can be seen in everything we do and in our everyday life. Sean is an advocate for positivity and shares motivation everywhere he goes. Sean is managed by his mom.
A nice study by Hoffmann et al. where nanobodies were inserted into various locations on adeno-associated virus (AAV) capsids. The authors also ablated hepatocyte tropism by mutating the heparan binding domain of the AAVs. These strategies greatly enhanced cell type specific targeting (in vitro).
Abstract. Adeno-associated virus (AAV) has been remarkably successful in the clinic, but its broad tropism is a practical limitation of precision gene therapy. A promising path to engineer AAV tropism is the addition of binding domains to the AAV capsid that recognize cell surface markers present on a targeted cell type. We have recently identified two previously unexplored capsid regions near the 2/5-fold wall and 5-fold pore of the AAV capsid that are amenable to insertion of larger protein domains, including nanobodies. Here, we demonstrate that these hotspots facilitate AAV tropism switching through simple nanobody replacement without extensive optimization in both VP1 and VP2. Our data suggest that engineering VP2 is the preferred path for maintaining both virus production yield and infectivity. We demonstrate highly specific targeting of human cancer cells expressing fibroblast activating protein (FAP). Furthermore, we found that the combination of FAP nanobody insertion plus ablation of the heparin binding domain can reduce off-target infection to a minimum, while maintaining a strong infection of FAP receptor-positive cells. Taken together, our study shows that nanobody swapping at multiple capsid locations is a viable strategy for nanobody-directed cell-specific AAV targeting.
