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Category: biotech/medical – Page 2,633

Samsara is Developing Autophagy Boosting Therapies to Combat Aging

Samsara Therapeutics has completed a seed financing round in collaboration with Apollo Ventures, a venture capital company and biotech incubator that supports longevity research and treatments for age-related diseases.

Samsara Therapeutics, Inc. (“Samsara,”) a platform biotechnology startup engaged in the discovery and development of compounds that address the primary molecular causes of aging, announced today the closing of a seed financing round. The financing was led by Apollo Ventures, a life sciences venture capital firm and company builder working across Europe and North America.

Additionally, on February 19th, 2019 Nature Communications published a peer-reviewed paper, “The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species” authored by Samsara’s scientific team [1]. The paper demonstrates the capability of the Samsara platform to identify novel MoA geroprotective small molecules that extend healthy lifespan across species and which are protective in mammalian models of disease.

Graphene Shows Promise for Repairing Broken Bones

When you were a kid, did you ever sign a classmate’s cast after they broke an arm or a leg? Your name would be on display there for the rest of the semester. Broken bones are one of the worst trade-offs in childhood—a few seconds of calamity followed by months of boring rest and recovery. But children in the future may have a different story to tell as emerging tech overhauls how we fix broken bones.

Carbon nanomaterials may have the power to heal bones faster than a Harry Potter fan can say ‘Brackium Emendo!’ Researchers from Stefanie A. Sydlik’s team at Carnegie Mellon University have tested a new formulation of graphene that is biodegradable, mimics bone, attracts stem cells, and ultimately improves how animals can repair damage to their skeletons.

As reported in PNAS, this phosphate graphene serves as a scaffold, allowing the body’s own cells to more rapidly reform the missing or damaged bone. The technique has already shown success in mice. As this technology matures it could become a vital part of orthopedic medicine, helping us recover faster with stronger, healthier bones.

Chirality yields colossal photocurrent

A recently discovered Weyl semimetal delivers the largest intrinsic conversion of light to electricity of any material, an international team lead by a group of Boston College researchers reports today in the journal Nature Materials.

The discovery is based on a unique aspect of the material where electrons can be separated by their chirality, or handedness—similar to DNA. The findings may offer a new route to efficient generation of electricity from light, as well as for thermal or .

“We discovered that the Weyl semimetal Tantalum Arsenide, has a colossal bulk photovoltaic effect—an intrinsic, or non-linear, generation of current from light more than ten times larger than ever previously achieved,” said Boston College Associate Professor of Physics Kenneth Burch, a lead author of the article, titled “Colossal mid-infrared bulk photovoltaic effect in a type-I Weyl semimetal.”

Advances in stem cell treatment give hope to millions with ‘incurable’ diseases

The announcement that a London man has become the second in the world to be “functionally cured” of HIV is a major advance in stem cell transplant therapy.

The man — who wishes to remain anonymous — was given stem cells from a donor with genetic resistance to the disease and he has now been in long term remission for 18 months without medication.

The breakthrough comes ten years after the first such case of a patient with HIV going into sustained remission, known as the ‘Berlin Patient.’

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