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Category: biotech/medical – Page 2,602

In sync: How cells make connections could impact circadian rhythm

If you’ve ever experienced jet lag, you are familiar with your circadian rhythm, which manages nearly all aspects of metabolism, from sleep-wake cycles to body temperature to digestion. Every cell in the body has a circadian clock, but researchers were unclear about how networks of cells connect with each other over time and how those time-varying connections impact network functions.

In research published Aug. 27 in PNAS, researchers at Washington University in St. Louis and collaborating institutions developed a unified, data-driven computational approach to infer and reveal these connections in biological and chemical oscillatory networks, known as the topology of these , based on their time-series data. Once they establish the topology, they can infer how the agents, or cells, in the network work together in synchrony, an important state for the brain. Abnormal synchrony has been linked to a variety of brain disorders, such as epilepsy, Alzheimer’s disease and Parkinson’s disease.

Jr-Shin Li, professor of systems science & mathematics and an applied mathematician in the School of Engineering & Applied Science, developed an algorithm, called the ICON (infer connections of networks) method, that shows for the first time the strength of these connections over time. Previously, researchers could only determine whether a connection existed between networks.

Singapore hit by ‘most serious’ cyberattack, resulting in theft of health data of 1.5 million people – including the prime minister

Wealthy Singapore is hyper-connected and on a drive to digitise government records and essential services, including medical records which public hospitals and clinics can share via a centralised database.

But authorities have put the brakes on these plans while they investigate the cyberattack. A former judge will head a committee looking into the incident.

While the city state has some of the most advanced military weaponry in the region, the government says it fends off thousands of cyberattacks every day and has long warned of breaches by actors as varied as high-school students in their basements to nation states.

Study Shows Telomerase Gene Therapy Does Not Increase Cancer Risk

Researchers have demonstrated that telomerase gene therapy does not increase the risk of cancer, even in strains of mice that are particularly susceptible to cancer [1].

A tale of telomeres

Short telomeres trigger cellular senescence and are thought to be one of the primary hallmarks of aging, which has led to various researchers seeking ways to restore the telomeres in order to prevent cells from dying and to encourage division and tissue regeneration. We won’t go over the basics of telomeres and how they influence aging here, but if you would like to learn more, check out our telomeres article, which explains it all.

The natural sugar that reduces the risk of diabetes in mice

Sugar may be the villain of our time, with too much of the sweet stuff known to be a leading cause of developing diabetes. But now researchers at Washington University School of Medicine in St. Louis have discovered a new way to reduce the risk of this condition – sugar. Trehalose is a natural sugar that has now been found to deprive the liver of glucose and activate a gene that improves insulin sensitivity and triggers the burning of more fat.

Insecure Medical Devices Are Low-Hanging Fruit for Hackers

“The big problem is that hospitals don’t buy new devices, and they keep using really dangerous ones ad infinitum — until they just stop working,” Corman said.

Corman wants these old, unsecured devices gone from hospitals. The fear is that, beyond freezing systems or hijacking medical records as they did during WannaCry, hackers could also actively manipulate medical equipment to harm patients by, say, administering a lethal dose of medication via an infusion pump. While newer devices aren’t ironclad, they are typically built with more robust security features. So Corman and others are urging health-care providers to scrap old, or “legacy,” equipment and replace it with newer models.

To nudge health-care providers to trade up, he’s put forth an idea for an incentive program akin to “Cash for Clunkers,” the 2009 federal auto-rebate plan that aimed to run gas-guzzling cars off the road. Under that program, which was formally called the Car Allowance Rebate System, people received cash in exchange for turning in fuel-inefficient vehicles, which they could then put toward new, more efficient ones. (The program fizzled after a few months, when it depleted its allotted budget.) Similarly, in this version, health-care providers would be compensated for junking old equipment, and could use the rebates toward the purchase of new devices. Corman said he hasn’t fully worked out the economics, but he believes device makers might be willing to subsidize the program in part, since it would help them move inventory.

Startup Proposes Using Stem Cells From Placentas for Regenerative Medicine

Our ultimate mission is to make 100 years old the new 60.”

A new exploration of stem cells from placentas could drastically advance regenerative medicine. Peter Diamandis, X-Prize and Singularity University founder, recently teamed up with Robert Hariri, the founder of Celgene Cellular Therapeutics, to study these specific stem cells in the hopes of discovering new regenerative therapies.

The initiative, called Celularity, is built around the idea that stem cells found in the human placenta (which transports nutrients to fetuses as they grow) are ideal for regenerating tissue and organs. According to Celularity, the cells can be taken from any placenta, which typically just gets discarded, and placed into any human without the risk of rejection.