Lifeboat Foundation

The findings showed that the shrinking of the hippocampus — brain region associated with learning and memory — actually precedes the onset of a change in behaviour — namely the loss of memory. “Until now, no one knew the evolution of these changes. Does the hippocampus shrink before or after memory loss? Or do the two happen handin- hand,” said Sumantra Chattarji, Professor at National Centre for Biological Sciences in Bengaluru, Karnataka, in a statement.

Using rats as a model system which reacts to stress much as humans do, the team studied how the brain changes in structure during stress. The results showed that when under stress, rats develop anxiety-related behaviours and their ability to form memories are affected. In the study, rats were subjected to stress for two hours every day over 10 days. The brains were examined with MRI scans on several days over the course of the study, and their ability to form memories were assessed repeatedly.

After just three days of stress, the hippocampus of every stressed rat had shrunk. “Normally structural changes are seen in the brain after a long time — say 10 to 20 days. Three days doesn’t even count as chronic stress,” Chattarji added. Five days after stress exposure, the rats’ hippocampus-based ability to make memories was tested again. The stressed rats were found to perform almost as well as unstressed rats, the researchers said. “Volume loss and shrinkage has happened, yet spatial memory is still holding up,” Chattarji said.

Continue reading “Brain scan during stress may predict memory loss” »

I see many uses for this such as provider services including front office & hospital admissions, security in assessing people in line or trying to gain entry, etc.

Machines are taking over more and more tasks. Ideally, they should also be capable to support the human in case of poor performance. To intervene appropriately, the machine should understand what is going on with the human. Fraunhofer scientists have developed a diagnostic tool that recognizes user states in real time and communicates them to the machine.

The camera firmly focuses on the driver’s eyes. If they are closed for more than one second, an alarm is triggered. This technique prevents the dangerous micro-sleep at the wheel. “It is not always as easy for a machine to detect what state the human is in, as it is in this case,” says Jessica Schwarz from the Fraunhofer Institute for Communication, Information Processing and Ergonomics FKIE in Wachtberg, just south of Bonn.

Continue reading “Computers will be able to assess humans’ state of mind” »

Big Data and 3D.

3D printing remains one of those technological areas that holds a great amount of fascination. What began as a type of niche market has expanded rapidly in the past few years to encompass nearly every industry out there, from the medical field to manufacturing.

The outlook is a positive one in terms of 3D printing’s future, with Gartner predicting the amount of spending on 3D printers to exceed more than $13 billion in 2018. While 3D printing has always held a lot of promise, one of the factors truly taking the concept to the next level is big data.

Continue reading “Big Data’s Role in 3D Printing” »

Nice.

When we think of synthetic biology, we often think of engineering a cell to give it some useful function. But SEED 2016 had quite a few speakers working outside of a biological cell. Some broke open cells to utilize just the cellular machinery to create “cell-free” systems. Others showed what could be done inside of the computer (in silico) to improve our understanding and prediction of synthetic gene networks. Here, we’re highlighting SEED speakers who showed how both of these approaches can advance synthetic biology.

Cell-free synthetic biology

Continue reading “SEED 2016: What can we do outside of a cell?” »

Listen to famed biogerontolgist Aubrey de Grey explain the OncoSENS approach to curing ALT-Cancer (https://www.lifespan.io/campaigns/sens-control-alt-delete-cancer/) and how this is a vital part of overcoming the ill-effects of aging. This presentation is part of the Designing New Advances conference held by the Institute of Exponential Sciences in the Netherlands.

Tempus fugit. I’m just about old enough to remember a time in which 2020 was the distant future of science fiction novels, too far away to be thinking about in concrete terms, a foreign and fantastical land in which anything might happen. Several anythings did in fact happen, such as the internet, and the ongoing revolution in biotechnology that has transformed the laboratory world but leaks into clinics only all too slowly. Here we are, however, close enough to be making plans and figuring out what we expect to be doing when the third decade of the 21st century gets underway. The fantastical becomes the mundane. We don’t yet have regeneration of organs and limbs, or therapies to greatly extend life, but for these and many other staples of golden age science fiction, the scientific community has come close enough to be able to talk in detail about the roads to achieving these goals.

Of all the things that researchers might achieve with biotechnology in the near future, control over aging is by far the most important. Aging is the greatest cause of death and suffering in the world, and none of us are getting any younger. That may change, however. SENS, the Strategies for Engineered Negligible Senescence, is a synthesis of the scientific view of aging as an accumulation of specific forms of cell and tissue damage, pulling in a century of evidence from many diverse areas of medical science to support this conclusion. Aging happens because the normal operation of our cellular biochemistry produces damage, wear and tear at the level of molecules and molecular structures, and some of that damage accumulates to cause failure of tissues and organs, and ultimately death.

Philadelphia, PA, USA / Mexico City, Mexico — Bioquark, Inc., (www.bioquark.com) a life sciences company focused on the development of novel bioproducts for complex regeneration, disease reversion, and aging, and RegenerAge SAPI de CV, (www.regenerage.clinic/en/) a clinical company focused on translational therapeutic applications of a range of regenerative and rejuvenation healthcare interventions, have announced a collaboration to focus on novel combinatorial approaches in human disease and wellness. SGR-Especializada (http://www.sgr-especializada.com/), regulatory experts in the Latin American healthcare market, assisted in the relationship.

“We are very excited about this collaboration with RegenerAge SAPI de CV,” said Ira S. Pastor, CEO, Bioquark Inc. “The natural synergy of our cellular and biologic to applications of regenerative and rejuvenative medicine will make for novel and transformational opportunities in a range of degenerative disorders.”

As we close in on $7 trillion in total annual health care expenditures around the globe ($1 trillion spent on pharmaceutical products; $200 billion on new R&D), we are simultaneously witnessing a paradoxical rise in the prevalence of all chronic degenerative diseases responsible for human suffering and death.

Continue reading “Bioquark Inc. and RegenerAge SAPI de CV to Collaborate on Clinical Regenerative Healthcare” »

Nice!

IBM scientists have developed a new lab-on-a-chip technology that can, for the first time, separate biological particles at the nanoscale and could help enable physicians to detect diseases such as cancer before symptoms appear.

As reported today in the journal Nature Nanotechnology (“Nanoscale Lateral Displacement Arrays for Separation of Exosomes and Colloids Down to 20nm”), the IBM team’s results show size-based separation of bioparticles down to 20 nanometers (nm) in diameter, a scale that gives access to important particles such as DNA, viruses and exosomes. Once separated, these particles can be analyzed by physicians to potentially reveal signs of disease even before patients experience any physical symptoms and when the outcome from treatment is most positive. Until now, the smallest bioparticle that could be separated by size with on-chip technologies was about 50 times or larger, for example, separation of circulating tumor cells from other biological components.

Continue reading “Lab-on-a-Chip breakthrough aims to help physicians detect cancer and diseases at the nanoscale” »

Imagine you wake up one morning burning to make the great physicist Max Planck’s face out of copper. (Just go with it.) Sure, you could sculpt it, but there’s a better way. Cut a flat copper sheet into a half-oval, and take a triangle out of the center of its straight edge. Divide it into smaller triangles, bend the sheet so that the two sides of the big triangle touch—and violà! A sheet of flat copper triangles has morphed to match every nook and cranny of Planck’s face. No sculpting required.

If that sounds like magic … well, that’s understandable, because we left a few steps out. Computer scientist Keenan Crane from Carnegie Mellon University actually did this with real copper, and you can see a computer model of the final product at the top of this article. Making Planck’s face wasn’t the point, of course: When Crane cut the sheet into carefully-designed triangles, he brought it into a class of materials known as auxetics, whose curious and complex properties have excited researchers for decades. Someday, auxetics could improve highway shock absorbers, form more comfortable and versatile shoes, and line veins that thicken when expanding.

At least, that’s what the grant applications say. “People give a lot of lip service to how it’s gonna change the world, in terms of curing cancer,” says Crane. “But at this stage people are still trying to figure out just basic questions.” Auxetics all started with a 1987 Science paper by engineer and professor Roderic Lakes. He reported a new kind of polymer foam that contradicted common sense. It expanded in one direction when stretched in another, and contracted in one direction when squeezed in another.