Lifeboat Foundation

A team of engineers has developed a new RNA delivery technique that uses short bursts of ultrasound to efficiently deliver RNA into cells, reducing colon inflammation.

MIT and Brigham and Women’s Hospital researchers have demonstrated that they can deliver strands of RNA efficiently to colon cells, using bursts of ultrasound waves that propel the RNA into the cells. Using this approach, the researchers dramatically turned down the production of a protein involved in inflammatory bowel disease (IBD), in mice.

“What we saw in this paper was the ultrasound can enable rapid delivery of these molecules,” says Carl Schoellhammer, a postdoc at MIT’s Koch Institute for Integrative Cancer Research and the study’s lead author. “In this case it was proinflammatory molecules that we were shutting off, and we saw tremendous knockdown of those proteins.”

Continue reading “New Delivery Technique Enables Rapid Treatment for Inflammation” »

Eeek.

(HealthDay)—Eight people who worked at several rat-breeding facilities in Illinois and Wisconsin have been infected with a virus not commonly found in the United States, federal health officials said Friday.

This is the first known outbreak of Seoul virus associated with pet rats in the United States, although there have been several outbreaks in wild rats, according to the federal Centers for Disease Control and Prevention.

Continue reading “8 people infected in rare U.S. outbreak of rat virus” »

Not good to hear.

(HealthDay)—For patients with unresected anaplastic thyroid carcinoma (ATC), overall survival (OS) is poor, but radiation therapy (RT) dose is associated with improved survival, according to a study published online Dec. 27 in Cancer.

Todd A. Pezzi, from the Baylor College of Medicine in Houston, and colleagues examined the outcomes of patients with unresected ATC who underwent no surgery or grossly incomplete resection. The authors assessed correlates of OS for 1,288 patients.

Continue reading “Overall survival poor in unresected anaplastic thyroid CA” »

A “smart” needle with an embedded camera is helping doctors perform safer brain surgery.

The device was developed by researchers at the University of Adelaide in South Australia and uses a tiny camera to identify at-risk blood vessels.

Continue reading “Internet of Things smart needle probes the brain during surgery” »

In Brief:

• Predictions from the co-chair of the World Economic Forum’s Future Council, Melanie Walker, say we’ll soon enter a post-hospital world due to advances in personalized medicine, health monitoring, and nanotechnology.
• New and evolving technologies in medical science convince Walker we’ll live in a society not dependent on hospitals by 2030.

As the world of medicine is increasingly changed by biology, technology, communications, genetics, and robotics, predicting the outlook of the next few decades of medicine becomes harder. But that is exactly what Melanie Walker of the World Economic Forum does, and she predicts a bright new future for healthcare.

Why is it so hard to convince people living longer is a good thing? This short article has some evidence worth considering.

Most advocates of life extension report facing resistance to the idea of increased lifespans by medical means when trying to disseminate this idea among general public. Resistance manifests itself in many forms, ranging from concerns such as overpopulation to concerns about unequal access to life extending treatments. But the most unexpected thing is probably that people often don’t want an increased lifespan at all. Surveys in different countries show, that when people are asked “how long would you like to live?”, they often give a number equal to or slightly higher than the current life expectancy in a given country[1–4].

But wait… Isn’t extending life for more decades a good thing that everyone should strive for? In reality we often do not see enough enthusiasm for the idea in general. So why is this?

Continue reading “Intrinsic resistance to the idea of life extension or wrong messaging?” »

Microbial burden is a real problem in aging and researchers are finding ways to boost our immune system to resist these microscopic enemies.

Microbial burden is a significant contribution to aging and our bodies are under daily attack from these microscopic invaders. The more completely we can remove these invaders the less impact they will have on the aging process.

“Researchers at the University of Illinois at Urbana-Champaign and Newcastle University in the U.K. are investigating how infectious microbes can survive attacks by the body’s immune system. By better understanding the bacteria’s defenses, new strategies can be developed to cure infections that are currently resistant to treatments, the researchers said”

Continue reading “Team discovers how bacteria exploit a chink in the body’s armor” »

Synthetic chemicals commonly found in insecticides and garden products bind to the receptors that govern our biological clocks, University at Buffalo researchers have found. The research suggests that exposure to these insecticides adversely affects melatonin receptor signaling, creating a higher risk for metabolic diseases such as diabetes.

Published online on Dec. 27 in Chemical Research in Toxicology, the research combined a big data approach, using computer modeling on millions of chemicals, with standard wet-laboratory experiments. It was funded by a grant from the National Institute of Environmental Health Sciences, part of the National Institutes of Health.

Disruptions in human circadian rhythms are known to put people at higher risk for diabetes and other metabolic diseases but the mechanism involved is not well-understood.

The graphene temporary tattoo seen here is the thinnest epidermal electronic device ever and according to the University of Texas at Austin researchers who developed it, the device can take some medical measurements as accurately as bulky wearable sensors like EKG monitors. From IEEE Spectrum:

Graphene’s conformity to the skin might be what enables the high-quality measurements. Air gaps between the skin and the relatively large, rigid electrodes used in conventional medical devices degrade these instruments’ signal quality. Newer sensors that stick to the skin and stretch and wrinkle with it have fewer airgaps, but because they’re still a few micrometers thick, and use gold electrodes hundreds of nanometers thick, they can lose contact with the skin when it wrinkles. The graphene in the Texas researchers’ device is 0.3-nm thick. Most of the tattoo’s bulk comes from the 463-nm-thick polymer support.

The next step is to add an antenna to the design so that signals can be beamed off the device to a phone or computer, says (electrical engineer Deji) Akinwande.

Continue reading “Thinnest-ever electronic tattoos are capable of precision health monitoring” »