Lifeboat Foundation

Science is making progress on the treatment of aging and age-releated diseases but should you rush out and start your own testing or not? This article weighs up some of the pros and cons.

Senescent cells accumulate with age, and secrete an unfortunate combination of signals that harms organs and tissues in numerous ways, such as via the production of increased chronic inflammation. This is one of the root causes of aging and age-related disease. Safe and effective clearance of senescent cells has been on the SENS rejuvenation biotechnology agenda for fifteen years, but only recently has progress in scientific funding and demonstrations of improved health and life spans in mice snowballed to the point at which startup companies could make a real go of it. Things are moving fairly rapidly in this field now. With the recent $116 million venture investment in UNITY Biotechnology’s work on senescent cell clearance, and other companies angling for their own launch, it is fair to say that this line of research and development is underway for real. Clinical trials of senescent cell clearance will be underway soon, funded by UNITY Biotechnology, and using drug candidates such as navitoclax developed in the cancer research community, noted for their ability to induce apoptosis, a form of programmed cell death. Senescent cells are primed for apoptosis, and it takes little to tip them over the edge in comparison to a normal somatic cell, which means that there may well be quite a large stable of existing drugs that will have some useful effect.

The question here is one that is only now starting to be useful to ask: should we all be running out today to obtain and take a drug (such as navitoclax) or drug combination (such as dasatinib and quercetin) that were shown to clear some fraction of senescent cells in rodents? Certainly there have been no shortage of people chasing after whatever the current hype of the day was in past years; I’m sure you all recall resveratrol and other alleged calorie restriction mimetics or telomere length enhancers. All a waste of time and effort. The difference between the science behind those and the science between senescent cell clearance is considerable, however. The items of the past have all been associated with altering metabolism so as to modestly slow aging, at best, and we have the very good examples of calorie restriction and exercise to show us the immediate bounds of the plausible on that front in our species.

Continue reading “On the Topic of Senescent Cells: Should We All be Trying to Take Navitoclax?” »

The SRF November newsletter is out now!

SENS Research Foundation email newsletter from 1st November 2016.

For the first time, researchers have achieved superconductivity — the phenomenon of electrical conductivity with zero resistance — in a material that’s not a superconductor.

The new technique demonstrates a concept that was first proposed back in the 1970s, but until now had never been proven, and it could lead to ways to make existing superconductors, like the ones used in MRI machines or maglev trains, cheaper and more efficient at higher temperatures.

“Superconductivity is used in many things, of which MRI (magnetic resonance imaging) is perhaps the best known,” said lead researcher Paul C. W. Chu from the University of Houston.

Continue reading “Physicists have achieved superconductivity in a non-superconductive material” »

Rattling around inside a hard drive doesn’t sound like an awful lot of fun — but then, neither does death.

Both eventualities are rather difficult to imagine, but we’ll all have to give them some thought sooner rather than later. Neuroscientist and neuroengineer Randal Koene thinks it’s only going to be another 10 years before we replace parts of the brain with prosthetics.

From there, it’s just a matter of replacing each region systematically, to end up with someone whose brain is immortal and electronic. Could the last person to die have already been born?

Continue reading “Would You Like to Be Uploaded to a Computer When You Die?” »

In a newly published study, nanoscientists look ahead to what we can expect in the coming decade, and conclude that nanoscience is poised to make important contributions in many areas, including health care, electronics, energy, food and water.

Nanoscience research involves molecules that are only 1/100th the size of cancer cells and that have the potential to profoundly improve the quality of our health and our lives. Now nine prominent nanoscientists look ahead to what we can expect in the coming decade, and conclude that nanoscience is poised to make important contributions in many areas, including health care, electronics, energy, food and water.

Significant progress has already been made in nanomaterials, report authors Paul Weiss, who holds a UC presidential chair and is a distinguished professor of chemistry and biochemistry at UCLA, and Dr. Andre Nel, chief of nanomedicine at the David Geffen School of Medicine at UCLA. In the journal ACS Nano, Weiss, Nel, who is a distinguished professor of medicine, and their colleagues say the following:

Continue reading “How Nanoscience Will Improve Our Lives in the Coming Years” »

Ready to leave your body behind? Scientists have developed robots that people can remotely control and embody using their minds, a breakthrough set to revolutionize the lives of paralyzed patients. The Virtual Embodiment and Robotic Re-Embodiment (VERE) project “aims at dissolving the boundary between the human body and surrogate representations in immersive virtual reality and physical reality,” meaning that people genuinely feel like the surrogate body is an extension of themselves. Three volunteers have tried out a prototype, and the results are promising.

“The feeling of actually embodying the robot was good, although needless to say, the sensation varied over time,” said Alessandro, a volunteer on the project, in an interview published Wednesday. “When the robot was stationary, the feeling of embodiment was low, but the moment I gave the first command or changed direction, there was this feeling of control and increased embodiment.”

The three volunteers, based in Italy, placed an electroencephalogram (EEG) cap on their heads that scanned for brain activity through the scalp. Patients were given a video feed of what a robot in Japan could see, superimposed with arrows. When the wearer focused on one arrow, the machine was able to detect the signal and send it remotely to the robot.

Continue reading “VERE’s Mind Control Robots Give Patients Out-of-Body Experience” »

15 years ago, Ray Kurzweil published one of the most significant essays in the history of futurism: “The Law of Accelerating Returns.” This piece showcased the immense power of exponential technology versus linear technology and became a pivotal concept for anyone trying to anticipate what the future held.

The essay predicted advances in business and technology with eerie precision, including how exponential growth would ripple through any technology that became an information technology, such as computing, biotechnology, or energy.

Continue reading “No Technology Thrives Alone: Progress Is All About Convergence” »

In Brief:

• New artificial blood vessels were able to grow with the recipient in recent animal testing
• Researchers saw a 56% increase in diameter made of patients’ own cells.

We have sufficiently advanced medicine to the point that artificial body parts are no longer science fiction. In fact, we may even start 3D printing organs, or have them grown in a lab. However, their artificial nature often means they won’t grow with a patient. For example, children need to undergo repeated surgeries until adulthood to replace implants they have outgrown.

https://www.singularityweblog.com/mic…

Dr. Michael Fossel is one of those few theoreticians who can see much of the big picture of aging. While some use mostly guesswork, and others hope to improve on that with logic, Fossel never shies away from the clear verdict that only data can give. Add his overwhelming compassion as a human being and you will understand why he is a clinician who really cares. You will also get a pretty good idea of what kind of a person Michael is – both personally and professionally. And those are just some of the reasons why enjoy having him back on my Singularity 1on1 podcast for an in-depth discussion of his latest book on the topic titled the Telomerase Revolution.

Continue reading “Michael Fossel on Aging and the Telomerase Revolution” »