When knowledge has advanced to a state that includes a predictive understanding of the relationship between genome sequence and organism phenotype it will be possible for future engineers to design and produce synthetic organisms. However, the possibility of synthetic biology does not necessarily guarantee its feasibility, in much the same way that the possibility of a brute force attack fails to ensure the timely breaking of robust encryption. The size and range of natural genomes, from a few million base pairs for bacteria to over 100 billion base pairs for some plants, suggests it is necessary to evaluate the practical limits of designing genomes of similar complexity.
The amniotic membrane (Amnio-M) has various applications in regenerative medicine. It acts as a highly biocompatible natural scaffold and as a source of several types of stem cells and potent growth factors. It also serves as an effective nano-reservoir for drug delivery, thanks to its high entrapment properties. Over the past century, the use of the Amnio-M in the clinic has evolved from a simple sheet for topical applications for skin and corneal repair into more advanced forms, such as micronized dehydrated membrane, amniotic cytokine extract, and solubilized powder injections to regenerate muscles, cartilage, and tendons. This review highlights the development of the Amnio-M over the years and the implication of new and emerging nanotechnology to support expanding its use for tissue engineering and clinical applications. Graphical Abstract.
Bioprinting is widely applicable to develop tissue engineering scaffolds and form tissue models in the lab. Materials scientists use this method to construct complex 3D structures based on different polymers and hydrogels; however, relatively low resolution and long fabrication times can result in limited procedures for cell-based applications.
In a new report now available in Nature Asia Materials, Byungjun Lee and a team of scientists in mechanical engineering at Seoul National University, Seoul, Korea, presented a 3D hybrid-micromesh assisted bioprinting method (Hy-MAP) to combine digital light projection, 3D printed micromesh scaffold sutures, together with sequential hydrogel patterning. The new method of bioprinting offered rapid cell co-culture via several methods including injection, dipping and draining. The work can promote the construction of mesoscale complex 3D hydrogel structures across 2D microfluidic channels to 3D channel networks.
Lee et al. established the design rules for Hy-MAP printing via analytical and experimental investigations. The new method can provide an alternative technique to develop mesoscale implantable tissue engineering constructs for organ-on-a-chip applications.
Northwestern University synthetic biologists have developed a low-cost, easy-to-use, hand-held device that can let users know—within mere minutes—if their water is safe to drink.
The new device works by using powerful and programmable genetic networks, which mimic electronic circuits, to perform a range of logic functions.
Among the DNA-based circuits, for example, the researchers engineered cell-free molecules into an analog-to-digital converter (ADC), a ubiquitous circuit type found in nearly all electronic devices. In the water-quality device, the ADC circuit processes an analog input (contaminants) and generates a digital output (a visual signal to inform the user).
𝙍𝙚𝙨𝙚𝙖𝙧𝙘𝙝𝙚𝙧𝙨 𝙛𝙧𝙤𝙢 𝙩𝙝𝙚 𝙐𝙣𝙞𝙫𝙚𝙧𝙨𝙞𝙩𝙚́ 𝙇𝙖𝙫𝙖𝙡 𝙁𝙖𝙘𝙪𝙡𝙩𝙮 𝙤𝙛 𝙈𝙚𝙙𝙞𝙘𝙞𝙣𝙚 𝙖… See more.
Researchers from the Université Laval Faculty of Medicine and CHU de Québec–Université Laval Research Center have successfully edited the genome of human cells grown in vitro to introduce a mutation providing protection against Alzheimer’s disease. The details of this breakthrough were recently published in The CRISPR Journal.
“Some genetic mutations increase the risk of developing Alzheimer’s disease, but there is a mutation that reduces this risk,” says lead author Professor Jacques-P. Tremblay. “This is a rare mutation identified in 2012 in the Icelandic population. The mutation has no known disadvantage for those who carry it and reduces the risk of developing Alzheimer’s disease. Using an improved version of the CRISPR gene editing tool, we have been able to edit the genome of human cells to insert this mutation.”
Not science, apparentlyLast month, a Ph.D. student at the Hebrew University of Jerusalem breed a new strain of ‘supercharged’ lettuce that expanded its vitamin C and beta carotene content by 800 percent and 70 percent respectively.
Research Interests.
Genomic/metabolomic/proteomic approaches for identification of novel (regulatory and biosynthetic) aroma genes.
Metabolic engineering of plants and yeast.
Site-specific genome modification and genetic engineering in plants.
A cloud-based repository that creates a digital fingerprint of engineered microorganisms has been successfully trialed.
An international team led by Newcastle University has launched CellRepo, a species and strain database that uses cell barcodes to monitor and track engineered organisms. Reported in a new study in the journal Nature Communications, the database keeps track and organizes the digital data produced during cell engineering. It also molecularly links that data to the associated living samples.
Available globally, this resource supports international collaboration and has significant safety advantages, such as limiting the impact of deliberately or accidentally released genetically modified microorganisms by enabling faster tracing of organisms lab of origin and design details.
Dr. Marvin Minsky — A.I. Pioneer & Mind Theorist. Professor of Media Arts and Sciences, MIT, Media Lab http://GF2045.com/speakers.
As soon as we understand how the human brain works, we should be able to make functional copies of our minds out of other materials. Given that everything is made of atoms, if you make a machine, in some sense it is made of the same kinds of materials as brains are made but organized either in very different ways or fundamentally the same ways.
Interestingly, if you are going to copy the organization of a particular human mind maybe you should make a dozen of them. There is no particular limit on how many copies to make and how the future society will treat them.
When will all these great things happen of overcoming death and making people more intelligent and turning ourselves into machines with replaceable parts so that suffering will disappear? Many great science fiction writers have written well about the future of human minds and what will happen if we eliminate death and people can live forever and we keep growing and so forth.
In my view, as we still do not know very much about how exactly the brain represents knowledge and does reasoning, it is very hard to predict how long it will take to do things like that. I however am fairly confident that, sooner or later, we will. Given that, in all likelihood, it does not require the breaking of any known rules of physics, and while it clearly represents a formidable science and engineering challenge, it is not a matter of “if” but a matter of “when” — it is a matter of time.
The Lifeboat Foundation is a nonprofit nongovernmental organization dedicated to encouraging scientific advancements while helping humanity survive existential risks and possible misuse of increasingly powerful technologies, including genetic engineering, nanotechnology, and robotics/AI, as we move towards the Singularity.
Lifeboat Foundation is pursuing a variety of options, including helping to accelerate the development of technologies to defend humanity, such as new methods to combat viruses, effective nanotechnological defensive strategies, and even self-sustaining space colonies in case the other defensive strategies fail.
We believe that, in some situations, it might be feasible to relinquish technological capacity in the public interest (for example, we are against the U.S. government posting the recipe for the 1918 flu virus on the internet). We have some of the best minds on the planet working on programs to enable our survival. We invite you to join our cause!
