Lifeboat Foundation

Big scientific breakthroughs often require inventions at the smallest scale. Advances in tissue engineering that can replace hearts and lungs will require the fabrication of artificial tissues that allow for the flow of blood through passages that are no thicker than a strand of hair. Similarly, miniature softbotic (soft-robot) devices that physically interact with humans safely and comfortably will demand the manufacture of components with complex networks of small liquid and airflow channels.

Advances in 3D printing are making it possible to produce such tiny structures. But for those applications that require very small, smooth, internal channels in specific complex geometries, challenges remain. 3D printing of these geometries using traditional processes requires the use of support structures that are difficult to remove after printing. Printing these models using layer-based methods at a high resolution takes a long time and compromises geometric accuracy.

Researchers at Carnegie Mellon University have developed a high-speed, reproducible fabrication method that turns the 3D printing process “inside out.” They developed an approach to 3D print ice structures that can be used to create sacrificial templates that later form the conduits and other open features inside fabricated parts.

If the combination of Covid-19 and remote work technologies like Zoom have undercut the role of cities in economic life, what might an even more robust technology like the metaverse do? Will it finally be the big upheaval that obliterates the role of cities and density? To paraphrase Airbnb CEO Brian Chesky: The place to be was Silicon Valley. It feels like now the place to be is the internet.

The simple answer is no, and for a basic reason. Wave after wave of technological innovation — the telegraph, the streetcar, the telephone, the car, the airplane, the internet, and more — have brought predictions of the demise of physical location and the death of cities.

Remote work has become commonplace since the beginning of the Covid-19 pandemic. But the focus on daily remote work arrangements may miss a larger opportunity that the pandemic has unearthed: the possibility of a substantially increased labor pool for digital economy work. To measure interest in digital economy jobs, defined as jobs within the business, finance, art, science, information technology, and architecture and engineering sectors, the authors conducted extensive analyses of job searches on the Bing search engine, which accounts for more than a quarter of all desktop searches in the U.S. They found that, not only did searches for digital economy jobs increase since the beginning of the pandemic, but those searches also became less geographically concentrated. The single biggest societal consequence of the dual trends of corporate acceptance of remote work and people’s increased interest in digital economy jobs is the potential geographic spread of opportunity.

Continue reading “Who Gets to Work in the Digital Economy?” »

The last known thylacine, also called the Tasmanian tiger, died at Australia’s Hobart Zoo in 1936. Now, a team of scientists believe they can resurrect the extinct species within 10 years, using stem cells and gene editing technology.

Circular ribonucleic acids (circRNAs) are a promising platform for gene expression studies as a stable and prevalent ribonucleic acid in eukaryotic cells, which arise from back-splicing. In a new report now published in Nature Biotechnology, Robert Chen and a team of interdisciplinary researchers at Stanford University, California, U.S., developed a systematic approach to rapidly assemble and test features affecting protein production based on synthetic circular RNAs. The team maximized translation of the circRNA by optimizing fine elements to implement design principles to improve circular RNA yield by several hundred-fold. The outcomes facilitated an increased translation of the RNA of interest, when compared to messenger RNA (mRNA) levels, to provide durable translation in vivo.

Developing circular RNA (circRNA) in the lab

Therapeutics based on ribonucleic acids span across messenger RNA (mRNA), small interfering RNAs (siRNA) and microRNAs (miRNA) with expansion into modern medicine including small molecules, biologics and cell therapeutics. For example, the lately popular mRNA vaccines can be designed in the lab and developed at a rapid pace to respond to evolving and urgent medical crises. Coding RNAs can be circularized into circRNAs to extend the duration of protein translation, based on RNA molecules that covalently join head-to-tail. Bioengineers have also advanced the synthesis of circular long transcripts into circRNAs. However, the fundamental mechanisms of initiating translation to form circular RNA or messenger RNA differ due to the lack of a 7-methylguanylate (M⁷G) cap on the circular RNAs. As a result of this, researchers need to thoroughly examine the principles of circular RNA translation to build better therapies and potentially surpass the translational capacities of mRNA.

Specific proteins in prokaryotes detect viruses in unexpectedly direct ways.

Bacteria use a variety of defense strategies to fight off viral infection. STAND ATPases in humans are known to respond to bacterial infections by inducing programmed cell death in infected cells. Scientists predict that many more antiviral weapons will be discovered in the microbial world in the future. Scientists have discovered a new unexplored microbial defense system in bacteria.

Researchers uncovered specific proteins in prokaryotes (bacteria and archaea) that detect viruses in unexpectedly direct ways, recognizing critical parts of the viruses and causing the single-celled organisms to commit suicide to stop the infection within a microbial community, according to a press release published in the official website of the Massachusetts Institute of Technology (MIT) on Thursday.

Continue reading “MIT researchers discover bacteria’s new antiviral defense system” »

Thor Balkhed/Linköping University.

Made of collagen protein from pig’s skin, the implant resembles the human cornea and is more than a pipe dream for an estimated number of 12.7 million people around the world who are blind due to their diseased corneas. The implant is a promising alternative to the transplantation of donated human corneas, which are scarce in under-developed and developing countries, where the need for them is greatest.

A pair of UCLA bioengineers and a former postdoctoral scholar have developed a new class of bionic 3D camera systems that can mimic flies’ multiview vision and bats’ natural sonar sensing, resulting in multidimensional imaging with extraordinary depth range that can also scan through blind spots.

Powered by computational image processing, the camera can decipher the size and shape of objects hidden around corners or behind other items. The technology could be incorporated into autonomous vehicles or medical imaging tools with sensing capabilities far beyond what is considered state of the art today. This research has been published in Nature Communications.

Continue reading “Bug eyes and bat sonar: Bioengineers turn to animal kingdom for creation of bionic super 3D cameras” »

Researchers and entrepreneurs have developed an implant made of collagen protein from pig’s skin, which resembles the human cornea. In a pilot study, the implant restored vision to 20 people with diseased corneas, most of whom were blind prior to receiving the implant.

The study jointly led by researchers at Linköping University (LiU) and LinkoCare Life Sciences AB has been published in Nature Biotechnology. The promising results bring hope to those suffering from corneal blindness and low vision by providing a bioengineered implant as an alternative to the transplantation of donated human corneas, which are scarce in countries where the need for them is greatest.

Motors are ubiquitous in our everyday lives — from cars to washing machines, even if we rarely notice them. A futuristic scientific field is working on the development tiny motors that could power a network of nanomachines and replace some of the power sources we currently use in electronic devices.

Researchers from the Cockrell School of Engineering at The University of Texas at Austin created the first ever solid-state optical nanomotor. All previous iterations of these light-driven motors reside in a solution of some sort, which limited their potential for the majority of real-world applications. This new research was published recently in the journal ACS Nano.

Continue reading “Tiny Motors Take a Big Step Forward: First-Ever Solid-State Optical Nanomotor” »