Lifeboat Foundation

BENGALURU: After working for five years, a team of three from department of Biosciences and Bioengineering (BSBE) at Indian Institute of Technology (IIT), Bombay and IITB-Monash Research Academy has designed smart amyloid based hydrogels that are able to guide stem cell to differentiate to neuron and successfully transplanted these stem cells in the brain of Parkinson’s disease (PD) animal models with unique amyloid hydrogels.

In Brief

• Researchers have discovered that placing synthetic genetic circuits in liposomes prevents them from interfering with one another, while still allowing them to communicate.
• Not only could this new form of “modular” genetic circuits lead to more complex engineered circuits, it could also provide insight as to how the earliest life on Earth formed.

By applying engineering principles to biology, researchers can create biological systems that don’t exist naturally. A problem of synthetic biology, however, is that these engineered genetic circuits can interfere with each other. While beneficial on their own, some of these man-made circuits become useless when they come in contact with each other, and this bars them from being used to solve complex biological problems.

Continue reading “Researchers Just Solved One of the Biggest Problems in Synthetic Biology” »

An Obama advisory group warns that advances in gene engineering have outpaced our ability to contain them.

SENS makes official comment on the excellent news about Mitochondrial repair from UCLA and Caltech.

So the big news is progress has been made on Mitochondrial repair. Our resident expert at the SENS Research Foundation, Dr. Matthew O’Connor of the MitoSENS project had this to say about the exciting news:

“New work from UCLA and Caltech has shown that a genetic pathway can be harnessed to selectively remove mutant mitochondria from the muscles of fruit flies. This work from Kandul et al is exciting because it raises the possibility of someday finding a way to control this genetic pathway in such a way to selectively delete mutant mitochondria. Further they did it in live flies in a tissue (muscle) where we are especially concerned about the impact of mitochondrial DNA mutations. Our ability to selectively control genetic pathways in non-genetically engineered animals (such as humans) is, however, extremely limited so it may be a long time before any clinical benefits can be realized from this research.” — Dr. Matthew O’Connor SRF

Continue reading “Turning back the aging clock” »

In China, there are fewer regulations and ethical quandaries standing in the way of genetic progress.

A world where DNA can be rewritten to fix deadly diseases has moved a step closer after scientists announced they had genetically-edited the cells of a human for the first time using a groundbreaking technique.

A man in China was injected with modified immune cells which had been engineered to fight his lung cancer. Larger trials are scheduled to take place next year in the US and Beijing, which scientists say could open up a new era of genetic medicine.

The technique used is called Crispr, which works like tiny molecular scissors snipping away genetic code and replacing it with new instructions to build better cells.

Continue reading “New era of ‘cut and paste’ humans close as man injected with genetically-edited blood” »

Progress in real science is steady, follows proper methodology and respects engineering safety. We live in an amazing world where medical progress is advancing rapidly, sadly we also have those willing to jump the gun hawking unproven experimental therapies without sufficient data.

Unproven therapies and people jumping the gun to make a quick buck are a plague in the aging research field. Real science is slow and methodical but ultimately gets results that ensure safe therapies can be deployed in the healthcare arena. At Lifespan.io we are passionate about supporting the progress of science that is conducted properly.

“The life science community should embrace the discrediting of unproven therapies promoted without data for economic gain, and instead focus on the promise of research held to the highest standards.”

Continue reading “Reviving optimism for regenerative medicine” »

Luv it! Wait until we make the marriage of QC meets Synbio — QC for the infrastructure and communications, and Synbio makes us all connected.

Cambridge, MA (Scicasts) — Synthetic biology allows scientists to design genetic circuits that can be placed in cells, giving them new functions such as producing drugs or other useful molecules. However, as these circuits become more complex, the genetic components can interfere with each other, making it difficult to achieve more complicated functions.

MIT researchers have now demonstrated that these circuits can be isolated within individual synthetic “cells,” preventing them from disrupting each other. The researchers can also control communication between these cells, allowing for circuits or their products to be combined at specific times.

Continue reading “Synthetic Cells to Isolate Genetic Circuits Created” »

There weren’t many people who had heard of bioterrorism before 9/11. But shortly after the September 11th terrorist attacks, a wave of anthrax mailings diverted the attention of the public towards a new weapon in the arsenal of terrorists—bioterrorism. A US federal prosecutor found that an army biological researcher was responsible for mailing the anthrax-laced letters, which killed 5 and sickened 15 people in 2001. The cases generated huge media attention, and the fear of a new kind of terrorist warfare was arising.

However, as with every media hype, the one about bioterrorism disappeared quickly.

But looking toward the future, I believe that we may not be paying as much attention to it as we should. Although it may be scary, we have to prepare ourselves for the worst. It is the only way we can be prepared to mitigate the damages of any harmful abuses if (and when) they arise.

Continue reading “The Future of Extremism: Artificial Intelligence and Synthetic Biology Will Transform Terrorism” »