CRISPR/Cas9 is a gene editing tool that has revolutionized biomedical research and led to the first FDA-approved CRISPR-based gene therapy. However, until now, the precise mechanism of exactly how this tool works and avoids creating detrimental off-target effects was not well understood.
Posted in bioengineering, biotech/medical, cyborgs, education, ethics, genetics, information science, robotics/AI | Leave a Comment on Michael Levin: What is Synthbiosis? Diverse Intelligence Beyond AI & The Space of Possible Minds
Michael Levin is a Distinguished Professor in the Biology department at Tufts University and associate faculty at the Wyss Institute for Bioinspired Engineering at Harvard University. @drmichaellevin holds the Vannevar Bush endowed Chair and serves as director of the Allen Discovery Center at Tufts and the Tufts Center for Regenerative and Developmental Biology. Prior to college, Michael Levin worked as a software engineer and independent contractor in the field of scientific computing. He attended Tufts University, interested in artificial intelligence and unconventional computation. To explore the algorithms by which the biological world implemented complex adaptive behavior, he got dual B.S. degrees, in CS and in Biology and then received a PhD from Harvard University. He did post-doctoral training at Harvard Medical School, where he began to uncover a new bioelectric language by which cells coordinate their activity during embryogenesis. His independent laboratory develops new molecular-genetic and conceptual tools to probe large-scale information processing in regeneration, embryogenesis, and cancer suppression.
TIMESTAMPS:
0:00 — Introduction.
1:41 — Creating High-level General Intelligences.
7:00 — Ethical implications of Diverse Intelligence beyond AI & LLMs.
10:30 — Solving the Fundamental Paradox that faces all Species.
15:00 — Evolution creates Problem Solving Agents & the Self is a Dynamical Construct.
23:00 — Mike on Stephen Grossberg.
26:20 — A Formal Definition of Diverse Intelligence (DI)
30:50 — Intimate relationships with AI? Importance of Cognitive Light Cones.
38:00 — Cyborgs, hybrids, chimeras, & a new concept called “Synthbiosis“
45:51 — Importance of the symbiotic relationship between Science & Philosophy.
53:00 — The Space of Possible Minds.
58:30 — Is Mike Playing God?
1:02:45 — A path forward: through the ethics filter for civilization.
1:09:00 — Mike on Daniel Dennett (RIP)
1:14:02 — An Ethical Synthbiosis that goes beyond “are you real or faking it“
1:25:47 — Conclusion.
EPISODE LINKS:
- Mike’s Round 1: https://youtu.be/v6gp-ORTBlU
- Mike’s Round 2: https://youtu.be/kMxTS7eKkNM
- Mike’s Channel: https://www.youtube.com/@drmichaellevin.
- Mike’s Website: https://drmichaellevin.org/
- Blog Website: https://thoughtforms.life.
- Mike’s Twitter: https://twitter.com/drmichaellevin.
- Mike’s Publications: https://scholar.google.com/citations?user=luouyakAAAAJ&hl=en.
- Mike’s NOEMA piece: https://www.noemamag.com/ai-could-be-a-bridge-toward-diverse-intelligence/
- Stephen Grossberg: https://youtu.be/bcV1eSgByzg.
- Mark Solms: https://youtu.be/rkbeaxjAZm4
- VPRO Roundtable: https://youtu.be/RVrnn7QW6Jg?feature=shared.
CONNECT:
Imagine owning a camera so powerful it can take freeze-frame photographs of a moving electron – an object traveling so fast it could circle the Earth many times in a second. Researchers at the University of Arizona have developed the world’s fastest electron microscope that can do just that.
They believe their work will lead to groundbreaking advancements in physics, chemistry, bioengineering, materials sciences and more.
“When you get the latest version of a smartphone, it comes with a better camera,” said Mohammed Hassan, associate professor of physics and optical sciences. “This transmission electron microscope is like a very powerful camera in the latest version of smartphones; it allows us to take pictures of things we were not able to see before – like electrons. With this microscope, we hope the scientific community can understand the quantum physics behind how an electron behaves and how an electron moves.”
Science And Engineering For Humanity — Dr. David Agus, MD — Founding Director & Co-CEO, Ellison Institute of Technology.
Dr. David B. Agus (https://davidagus.com/) is one of the world’s leading doctors and pioneering biomedical researchers.
Dr. Agus is the Founding Director and Co-CEO of the Ellison Institute of.
The great George Church takes us through the revolutionary journey of DNA sequencing from his early groundbreaking work to the latest advancements. He discusses the evolution of sequencing methods, including molecular multiplexing, and their implications for understanding and combating aging.
We talk about the rise of biotech startups, potential future directions in genome sequencing, the role of precise gene therapies, the ongoing integration of nanotechnology and biology, the potential of biological engineering in accelerating evolution, transhumanism, the Human Genome Project, and the importance of intellectual property in biotechnology.
The episode concludes with reflections on future technologies, the importance of academia in fostering innovation, and the need for scalable developments in biotech.
00:00 Introduction to Longevity and DNA Sequencing.
The technology’s promise can sound like science fiction—it might help us adapt to a radically different climate, or grow organs for people in need—but experts are also concerned about its potential side effects.
Every cell is beholden to a phenomenon called cell fate, a sort of biological preset determined by genetic coding. Burgeoning cells take their developmental cues from a set of core genetic instructions that shape their structure and function and how they interact with other cells in the body.
To you or me, it’s biological law. But to a group of researchers at Stanford Medicine, it’s more of a suggestion. Unconstrained by the rules of evolution, these scientists are instead governed by a question: What if?
What if you could eat a vaccine? Or create a bacterium that could also detect and attack cancer? What if furniture could grow from a seed?
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
An achievement that was deemed impossible has successfully become accomplished. For the first time in history, DNA can be edited. One of the goals is to be able to get rid of genetic diseases. This whole concept in genomic science has opened up a whole new revolutionary way of dealing with such critical health issues. There is a possibility that illnesses that were once incurable have a chance to be curable.
MedlinePlus provides a definition and states that a collection of tools known as genome editing, or gene editing, allows researchers to alter an organism’s DNA. These technologies enable the addition, deletion, or modification of genetic material at specific genomic regions. A person’s DNA can be altered through gene editing to fix mistakes that lead to illnesses.
CRISPR-Cas9, short for CRISPR-associated protein 9 and clustered regularly interspaced short palindromic repeats, is a well-known example as one of the approaches used and developed by scientists to edit DNA. The scientific community is very excited about the CRISPR-Cas9 system since it is more accurate, efficient, quicker, and less expensive than existing genome editing techniques.
Posted in bioengineering, biotech/medical, genetics, information science, robotics/AI | Leave a Comment on Compact ‘Gene Scissors’ enable Effective Genome Editing, may offer Future Treatment of High Cholesterol Gene Defect
CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known “gene scissors” but is much smaller and thus easier to transport into cells.
Using protein engineering and AI algorithms, University of Zurich researchers have now enhanced TnpB capabilities to make DNA editing more efficient and versatile, paving the way for treating a genetic defect for high cholesterol in the future. The work has been published in Nature Methods.
CRISPR-Cas systems, which consist of protein and RNA components, were originally developed as a natural defense mechanism of bacteria to fend off intruding viruses. Over the last decade, re-engineering these so-called “gene scissors” has revolutionized genetic engineering in science and medicine.
