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Scientists discover neural pathway that explains the escalation of fear responses

Posted in neuroscience

Survival requires the selection of appropriate behaviour in response to threats, and dysregulated defensive reactions are associated with psychiatric illnesses such as post-traumatic stress and panic disorder.


Scientists have discovered a new neural pathway involved in how the brain encodes the transition to high-intensity fear response behaviors that are necessary for survival, according to a recent study published in Nature.

Jones Parker, Ph.D., assistant professor of Neuroscience, of Pharmacology and of Psychiatry and Behavioral Sciences, was a co-author of the study.

In mammals, the amygdala is involved in generating survival responses and transitioning to different high-intensity behaviors such as freezing or immobility (avoidance behavior) to escaping (flight behavior) in response to perceived threats.