Jan 6, 2024

Horizontal gene transfer facilitates the molecular reverse-evolution of antibiotic sensitivity in experimental populations of H. pylori

Posted by in categories: biotech/medical, evolution

The authors evolved antibiotic-resistant Helicobacter pylori in the absence of antibiotics and presence of DNA from antibiotic-sensitive strains. Horizontal gene transfer mediated the molecular reverse evolution of the antibiotic-resistance gene to the antibiotic-sensitive allele, and the authors used theoretical modelling to determine the evolutionary conditions that promote reverse evolution.

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