Jul 29, 2023

Novel Raman technique breaks through 50 years of frustration

Posted by in categories: biotech/medical, chemistry, engineering, quantum physics

Raman spectroscopy—a chemical analysis method that shines monochromatic light onto a sample and records the scattered light that emerges—has caused frustration among biomedical researchers for more than half a century. Due to the heat generated by the light, live proteins are nearly destroyed during the optical measurements, leading to diminishing and non-reproducible results. As of recently, however, those frustrations may now be a thing of the past.

A group of researchers with the Institute for Quantum Sciences and Engineering at Texas A&M University and the Texas A&M Engineering Experiment Station (TEES) have developed a new technique that allows low-concentration and low-dose screenings of protein-to-ligand interactions in physiologically relevant conditions.

Titled thermostable-Raman-interaction-profiling (TRIP), this new approach is a paradigm-shifting answer to a long-standing problem that provides label-free, highly reproducible Raman spectroscopy measurements. The researchers published their findings in the Proceedings of the National Academy of Sciences.

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