Feb 27, 2023

New Study Finds Neurons Derived from Stem Cells Predict Psychosis and Cognitive Deficits in Individuals with Schizophrenia

Posted by in categories: biotech/medical, neuroscience

Baltimore, Md. (January 11, 2022) – In a breakthrough that holds significant promise for early diagnosis and better treatment of psychiatric illness, researchers have for the first time used neurons derived from human stem cells to predict the cardinal features of a psychiatric illness, such as psychosis and cognitive deficits in patients with schizophrenia.

A study published today in the Proceedings of the National Academy of Sciences (PNAS) by scientists at the Lieber Institute for Brain Development/Maltz Research Laboratories (LIBD) shows that the clinical symptoms of individuals with schizophrenia can be predicted by the activity of neurons derived from the patients’ own stem cells.

This connection — between the physiology of cells and symptoms like delusions, hallucinations and altered cognition— has never been made before. That is, no other study has demonstrated a robust association between neuronal models derived from a patient’s stem cells and clinically relevant features of the psychiatric disorder in the same person.

Comments are closed.