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Compass Pathways, a U.K. based clinical stage company that is developing a patented form of psilocybin to be used in conjunction with therapy, reported promising results from its much-anticipated phase two b clinical trial this week. The study found that patients who took a single psychedelic dose of psilocybin, 25 milligrams, in conjunction with therapy reported almost immediate and significant reduction in depressive symptoms that lasted weeks compared with patients who were given a 1 milligram dose, which is so low itโ€™s essentially a placebo.

Twenty-nine patients, or 36.7%, who took the 25 mg dose showed a 50% or more reduction in symptoms in three weeks after the single dose and again at three months, compared with the patients who took the placebo. Nineteen patients, or 24.1%, who took the highest dose were still in remission three months later, compared with 17.7% after three weeks and 10.1% after three months in the 1 mg group.

George Goldsmith, who cofounded Compass Pathways with his wife and medical doctor Ekaterina Malievskaia and Lars Christian Wilde, says that when they saw the positive results, they realized they were โ€œgroundbreaking.โ€