Imine-linked covalent organic frameworks (COFs) have been explored for various applications; however, chemical recycling of end-of-life COFs is an undeveloped area of research. Here, we report closed-loop recycling methods for imine-linked COFs, realizing their chemical depolymerization and reconstruction through d.
Abstract. The heart, a vital organ, works without interruption and constantly adjusts to the ever-changing demands on our body. It adapts to physiological and pathological changes, including exercise and emotional state, as well as metabolic, respiratory, and vascular abnormalities. The pumping action of the heart is determined by the health of the myocardium, which undergoes changes with ageing that are both under-investigated and incompletely understood, potentially impacting our approach to pathological conditions. Here, the alterations in cellular, tissue, and gross physiological function of the heart with age are discussed. At the molecular level, non-coding RNAs influence cellular senescence, and extracellular vesicles induce fibrosis through matrix remodelling. Mitochondrial dysfunction and altered fatty acid oxidation reduce cellular energetics, whilst accumulation of reactive oxygen species and steatosis, as well as telomere shortening coupled with reduced autophagy, limit the myocardium’s regenerative capability. Loss of cardiomyocytes, combined with senescence, requires compensatory hypertrophy, inducing myocardial stiffness and altered muscle function. In addition to these direct alterations in myocardial characteristics with ageing, other factors that can affect the myocardium indirectly are addressed, including valve calcification, resulting in regurgitation and/or stenosis; vascular abnormalities, reducing compliance and exacerbating hypertension; fibrosis leading to cardiac arrhythmias; and autonomic dysregulation, reducing cardiac adaptability. Finally, potential modulation of cardiac ageing is discussed whilst also addressing which senescent modifications should be considered as ageing-related physiological changes of the myocardium. A better understanding of myocardial ageing will differentiate physiological changes from early, preventable, and reversible pathological changes, consequently helping to optimize management of individuals with or at risk of myocardial disease by taking into account diverse trajectories of myocardial ageing.
Early IL-6 receptor inhibition with tocilizumab in AMI patients at increased risk of CS safely suppressed systemic inflammation but had an inconclusive effect on NT-proBNP, with a trend toward a favorable effect that did not reach statistical significance. No difference in LV infarct size as assessed with CMR was observed compared with placebo. JACC CRT2026.
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A research team led by Prof. Seunguk Song from the Department of Energy Science at Sungkyunkwan University (SKKU), in collaboration with the Institute for Basic Science (IBS), the University of Pennsylvania, and the U.S. Air Force Research Laboratory, has developed a comprehensive technical roadmap for two-dimensional (2D) indium selenides (InSe)—a key material for next-generation low-power and quantum computing.
The study, titled “Indium selenides for next-generation electronics and optoelectronics,” was published in Nature Reviews Electrical Engineering. This research provides a deep dive into the physical properties and device applications of 2D quantum semiconductors, which are viewed as a definitive alternative to silicon as it reaches its physical scaling limits.
As current silicon-based semiconductors shrink to the sub-nanometer scale, they face critical hurdles such as surging power consumption, overheating, and leakage current. To address these challenges, Professor Song’s team focused on InSe, an atomically thin material.
Physicists have discovered a surprising new “Island of Inversion” in a place no one expected: among nuclei where the number of protons equals the number of neutrons. For decades, these strange regions—where atomic nuclei abandon their usual orderly structure and become strongly deformed—were thought to exist only in highly neutron-rich isotopes far from stability. But experiments on molybdenum isotopes revealed that molybdenum-84 behaves dramatically differently from its close neighbor molybdenum-86, even though they differ by just two neutrons.
Austria’s scientists have created a leather made from mycelium. Growing mushrooms in low-oxygen chambers allows researchers to craft an alternative material that feels and looks like traditional leather. The finished textile is strong, flexible, and even fire-resistant.
Manufacturers grow the material instead of harvesting it from animals. After it reaches the desired thickness, they apply non-toxic enzymes to keep it fully biodegradable. The vegetative part of the fungus grows into a dense mat over a matter of days. Above all, it avoids the environmental impact of traditional leather production…
…This is not science fiction; fungal fabric has grown from a curiosity into reality. A 2025 report listed the benefits of mushroom leather as having a lower carbon footprint. It begins with a substantial reduction in water use. Growing mushrooms, compared to raising cattle, requires a fraction of the water.
Scientists created a mushroom leather made from mycelium that looks and feels like traditional leather. It’s grown in a matter of days.