Dr. Domenico Praticó
Domenico Praticó, M.D. is
Associate Professor, Pharmacology, Temple University School of
Medicine.
Domenico’s research area is clinical pharmacology with a special focus
on the
cellular and molecular aspects of cell oxidative biology and a
particular interest in small molecules such as bioactive oxidized
lipids.
This area is very broad and extends to multiple disciplines including
aging, cardiovascular diseases, as well as neurodegeneration. His work
in
the biology of oxidized bioactive lipids has significantly contributed
to the current understanding of their importance as biomarkers,
mediators of cellular and molecular events involved in the pathogenesis
of several clinical conditions, and therapeutic targets for preventing
and treating human diseases.
In his lab he employs cellular
and animal
models of human diseases, and in this context particular emphasis is
given to the translation of any observation made in these systems into a
better understanding of human physiology and pathology. He is
committed to foster collaborative scientific research of the highest
quality, and at the same time to provide outstanding teaching and
mentoring for young scientists.
Domenico coauthored
Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an
Animal Model of Alzheimer Amyloidosis,
Increased Formation of Distinct F2 Isoprostanes in
Hypercholesterolemia,
Increased F2-isoprostanes in Alzheimer’s disease: evidence
for
enhanced
lipid peroxidation in vivo,
Chronic Obstructive Pulmonary Disease Is Associated with an Increase
in
Urinary Levels of Isoprostane F2α-III, an Index of
Oxidant
Stress,
Effect of Low-Dose Aspirin on Vascular Inflammation, Plaque
Stability,
and Atherogenesis in Low-Density Lipoprotein Receptor-Deficient
Mice, and
Early Vitamin E supplementation in young but not aged
mice reduces Aβ levels and amyloid deposition in a
transgenic model of Alzheimer’s disease.
Domenico earned his
M.D. at the University of Rome “La Sapienza”, Rome, Italy in
1986.
Read
Diet High in Methionine Could Increase Risk of Alzheimer’s,
Can an Aspirin a Day Keep Atherosclerosis at Bay?,
Nicotine May Accelerate Atherosclerosis, May Be As Dangerous As
Tar,
Urine Test Predicts Alzheimer’s Disease, and
Penn Study Findings Reverse Key Chronology for Development of
Alzheimer’s Disease.