Mike Lustgarten – Lifeboat News: The Blog https://lifeboat.com/blog Safeguarding Humanity Sat, 31 Jul 2021 11:23:13 +0000 en-US hourly 1 https://wordpress.org/?v=5.7.2 Dietary CD38 Inhibitors: Are They Correlated With Biological Age? https://spanish.lifeboat.com/blog/2021/07/dietary-cd38-inhibitors-are-they-correlated-with-biological-age https://spanish.lifeboat.com/blog/2021/07/dietary-cd38-inhibitors-are-they-correlated-with-biological-age#respond Sat, 31 Jul 2021 11:23:13 +0000 https://lifeboat.com/blog/2021/07/dietary-cd38-inhibitors-are-they-correlated-with-biological-age

Apigenin, quercetin, luteolin data: USDA Database for the Flavonoid.
Content of Selected Foods.
https://www.ars.usda.gov/arsuserfiles/80400525/data/flav/flav_r03-1.pdf.

Kuromanin data: http://phenol-explorer.eu/contents/polyphenol/9

Patreon link:
https://www.patreon.com/MichaelLustgartenPhD

]]> https://spanish.lifeboat.com/blog/2021/07/dietary-cd38-inhibitors-are-they-correlated-with-biological-age/feed 0 Quantifying Biological Age: Blood Test #3 in 2021 https://spanish.lifeboat.com/blog/2021/07/quantifying-biological-age-blood-test-3-in-2021 https://spanish.lifeboat.com/blog/2021/07/quantifying-biological-age-blood-test-3-in-2021#respond Tue, 27 Jul 2021 12:24:27 +0000 https://lifeboat.com/blog/2021/07/quantifying-biological-age-blood-test-3-in-2021

Links to biological age calculators:
Levine’s PhenoAge calculator is embedded as an Excel file:

https://michaellustgarten.com/2019/09/09/quantifying-biological-age/

Aging.ai.

Papers referenced in the video:
A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study.
https://pubmed.ncbi.nlm.nih.gov/30596641/

Underlying features of epigenetic aging clocks in vivo and in vitro.
https://onlinelibrary.wiley.com/doi/full/10.1111/acel.

Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations.
https://pubmed.ncbi.nlm.nih.gov/29340580/

]]> https://spanish.lifeboat.com/blog/2021/07/quantifying-biological-age-blood-test-3-in-2021/feed 0 Epigenetic Age Reduction Within 8 Weeks: Real Effect Or Statistical Noise? https://spanish.lifeboat.com/blog/2021/07/epigenetic-age-reduction-within-8-weeks-real-effect-or-statistical-noise https://spanish.lifeboat.com/blog/2021/07/epigenetic-age-reduction-within-8-weeks-real-effect-or-statistical-noise#respond Thu, 22 Jul 2021 15:23:41 +0000 https://lifeboat.com/blog/2021/07/epigenetic-age-reduction-within-8-weeks-real-effect-or-statistical-noise

Paper referenced in the video:

Potential reversal of epigenetic age using a diet and lifestyle.
intervention: a pilot randomized clinical trial.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064200/

Patreon link:
https://www.patreon.com/MichaelLustgartenPhD

]]> https://spanish.lifeboat.com/blog/2021/07/epigenetic-age-reduction-within-8-weeks-real-effect-or-statistical-noise/feed 0 NMN Improves Aerobic Capacity in Runners https://spanish.lifeboat.com/blog/2021/07/nmn-improves-aerobic-capacity-in-runners https://spanish.lifeboat.com/blog/2021/07/nmn-improves-aerobic-capacity-in-runners#respond Sat, 17 Jul 2021 13:23:42 +0000 https://lifeboat.com/blog/2021/07/nmn-improves-aerobic-capacity-in-runners

Paper referenced in the video:

https://pubmed.ncbi.nlm.nih.gov/34238308/

]]> https://spanish.lifeboat.com/blog/2021/07/nmn-improves-aerobic-capacity-in-runners/feed 0 Lifespan Extension In Drosophila: A Conversation with Dr. Michael Rose (full, unedited video) https://spanish.lifeboat.com/blog/2021/07/lifespan-extension-in-drosophila-a-conversation-with-dr-michael-rose-full-unedited-video https://spanish.lifeboat.com/blog/2021/07/lifespan-extension-in-drosophila-a-conversation-with-dr-michael-rose-full-unedited-video#respond Thu, 15 Jul 2021 15:23:14 +0000 https://lifeboat.com/blog/2021/07/lifespan-extension-in-drosophila-a-conversation-with-dr-michael-rose-full-unedited-video

Timestamps:

0:00 How the Rose lab more than doubled the lifespan of Drosophila.
17:20 Use of machine learning (ML) and multi-‘omics to characterize aging, and use of ML to develop interventions.
37:04 Adherence to an ancestral diet in Drosophila extends healthspan relative to their evolutionary recent diet.
40:35 The importance of measuring objective markers of health to determine if one’s diet is best for them.
44:04 Does aging stop, and use of biomarker testing to help decipher/optimize that.
53:33 The importance of characterizing aging for both Drosophila and its co-associated microbiome.
1:00:35 Why a massive, wide-scale, Manhattan-project approach for increasing human lifespan is necessary.

]]> https://spanish.lifeboat.com/blog/2021/07/lifespan-extension-in-drosophila-a-conversation-with-dr-michael-rose-full-unedited-video/feed 0 Which Diet Is Optimal For Health: The Evolutionary Perspective (Part III Featuring Dr. Michael Rose) https://spanish.lifeboat.com/blog/2021/07/which-diet-is-optimal-for-health-the-evolutionary-perspective-part-iii-featuring-dr-michael-rose https://spanish.lifeboat.com/blog/2021/07/which-diet-is-optimal-for-health-the-evolutionary-perspective-part-iii-featuring-dr-michael-rose#respond Mon, 12 Jul 2021 16:25:57 +0000 https://lifeboat.com/blog/2021/07/which-diet-is-optimal-for-health-the-evolutionary-perspective-part-iii-featuring-dr-michael-rose

Paper referenced in the video:

Diet and Botanical Supplementation: Combination Therapy for Healthspan Improvement?
https://pubmed.ncbi.nlm.nih.gov/32924860/

]]> https://spanish.lifeboat.com/blog/2021/07/which-diet-is-optimal-for-health-the-evolutionary-perspective-part-iii-featuring-dr-michael-rose/feed 0 100% Lifespan Extension In Drosophila: A Conversation With Dr. Michael Rose https://spanish.lifeboat.com/blog/2021/07/100-lifespan-extension-in-drosophila-a-conversation-with-dr-michael-rose https://spanish.lifeboat.com/blog/2021/07/100-lifespan-extension-in-drosophila-a-conversation-with-dr-michael-rose#respond Thu, 08 Jul 2021 12:22:39 +0000 https://lifeboat.com/blog/2021/07/100-lifespan-extension-in-drosophila-a-conversation-with-dr-michael-rose

Paper referenced in the video:

Can human aging be postponed?
https://pubmed.ncbi.nlm.nih.gov/10614072/

Dr. Rose’s website: https://55theses.org/

]]> https://spanish.lifeboat.com/blog/2021/07/100-lifespan-extension-in-drosophila-a-conversation-with-dr-michael-rose/feed 0 Aspartate Aminotransferase: What’s Optimal, And Can It Be Improved? https://spanish.lifeboat.com/blog/2021/06/aspartate-aminotransferase-whats-optimal-and-can-it-be-improved https://spanish.lifeboat.com/blog/2021/06/aspartate-aminotransferase-whats-optimal-and-can-it-be-improved#respond Wed, 30 Jun 2021 12:22:46 +0000 https://lifeboat.com/blog/2021/06/aspartate-aminotransferase-whats-optimal-and-can-it-be-improved

Papers referenced in the video:

Loss of Life Expectancy by 10 Years or More From Elevated Aspartate Aminotransferase: Finding Aspartate Aminotransferase a Better Mortality Predictor for All-Cause and Liver-Related than Alanine Aminotransferase.
https://pubmed.ncbi.nlm.nih.gov/31425154/

Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study.
https://pubmed.ncbi.nlm.nih.gov/29491346/

]]> https://spanish.lifeboat.com/blog/2021/06/aspartate-aminotransferase-whats-optimal-and-can-it-be-improved/feed 0 Insulin Sensitivity Is A Hallmark Of Longevity https://spanish.lifeboat.com/blog/2021/06/insulin-sensitivity-is-a-hallmark-of-longevity https://spanish.lifeboat.com/blog/2021/06/insulin-sensitivity-is-a-hallmark-of-longevity#respond Mon, 21 Jun 2021 11:23:01 +0000 https://lifeboat.com/blog/2021/06/insulin-sensitivity-is-a-hallmark-of-longevity

HOMA calculator: https://www.omnicalculator.com/health/homa-ir.

Papers referenced in the video:
Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice.
https://pubmed.ncbi.nlm.nih.gov/24175087/

Glucose regulation and oxidative stress in healthy centenarians.
https://pubmed.ncbi.nlm.nih.gov/12543271/

Distribution of blood glucose and prevalence of diabetes among centenarians and oldest-old in China: based on the China Hainan Centenarian Cohort Study and China Hainan Oldest-old Cohort Study.
https://pubmed.ncbi.nlm.nih.gov/32643047/

Prevalence and Ethnic Pattern of Diabetes and Prediabetesin China in 2013
https://pubmed.ncbi.nlm.nih.gov/28655017/

Families enriched for exceptional longevity also have increased health-span: findings from the long life family study.
https://pubmed.ncbi.nlm.nih.gov/24350207/

]]> https://spanish.lifeboat.com/blog/2021/06/insulin-sensitivity-is-a-hallmark-of-longevity/feed 0 Selenium: How Much Is Optimal For Health? https://spanish.lifeboat.com/blog/2021/06/selenium-how-much-is-optimal-for-health https://spanish.lifeboat.com/blog/2021/06/selenium-how-much-is-optimal-for-health#respond Tue, 15 Jun 2021 12:22:39 +0000 https://lifeboat.com/blog/2021/06/selenium-how-much-is-optimal-for-health

For those who track their diet, eating only the RDA for many nutrients may not optimize health. For example, the RDA for selenium is 55 micrograms per day, but is that amount optimal for reducing risk of death for all causes?

Papers referenced in the video:

The role of mitochondrial DNA mutations and free radicals in disease and ageing.
https://pubmed.ncbi.nlm.nih.gov/23432181/

The Hallmarks of Aging.
https://pubmed.ncbi.nlm.nih.gov/23746838/

Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids.
https://www.ncbi.nlm.nih.gov/books/NBK225470/

Dietary and serum selenium in coronary heart disease and all-cause mortality: An international perspective.
https://pubmed.ncbi.nlm.nih.gov/33377378/

Association between selenium intake, diabetes, and mortality in adults: findings fromNational Health and Nutrition Examination Survey (NHANES) 2003–2014
https://pubmed.ncbi.nlm.nih.gov/34039451/

Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
https://pubmed.ncbi.nlm.nih.gov/30239557/

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