On the way to rejuvenation using AI and multidisciplinary knowledge!

An AI-generated small-molecule inhibitor treats fibrosis in vivo and in phase I clinical trials.

Humankind on the verge of evolutionary traps, a new study: …For the first time, scientists have used the concept of evolutionary traps on human societies at large.

For the first time, scientists have used the concept of evolutionary traps on human societies at large. They find that humankind risks getting stuck in 14 evolutionary dead ends, ranging from global climate tipping points to misaligned artificial intelligence, chemical pollution, and accelerating infectious diseases.

The evolution of humankind has been an extraordinary success story. But the Anthropocene—the proposed geological epoch shaped by us humans—is showing more and more cracks. Multiple global crises, such as the COVID-19 pandemic, climate change, food insecurity, financial crises, and conflicts have started to occur simultaneously in something which scientists refer to as a polycrisis.

Humans are incredibly creative as a species. We are able to innovate and adapt to many circumstances and can cooperate on surprisingly large scales. But these capabilities turn out to have unintentional consequences. Simply speaking, you could say that the human species has been too successful and, in some ways, too smart for its own future good, says Peter Søgaard Jørgensen, researcher at the Stockholm Resilience Center at Stockholm University and at the Royal Swedish Academy of Sciences’ Global Economic Dynamics and the Biosphere program and Anthropocene laboratory.

…Such moves are helping countries like the United Kingdom to develop the expertise needed to guide AI for the public good, says Bengio. But legislation will also be needed, he says, to safeguard against the development of future AI systems that are smart and hard to control.

We are on a trajectory to build systems that are extremely useful and potentially dangerous, he says. We already ask pharma to spend a huge chunk of their money to prove that their drugs aren’t toxic. We should do the same.

Doi: https://doi.org/10.1038/d41586-023-03472-x

UK and US governments establish efforts to democratize access to supercomputers that will aid studies on AI systems.

Human extinction? It could happen, but it doesn’t have to.

This resulted in a final recommendation for 8 natural compounds, 4 that have shown activity against other coronaviruses and that have strong immunomodulatory effects (see Recommended Based on Scientific Literature) along with 4 further compounds that have traditionally been used for prevention/treatment of viral infections with a long record of efficacy and safety (see Recommended Based on Clinical Practice).

Additionally, we found there is some supporting evidence for 23 more substances, discussed in the Potentially Useful section…” https://brain.forever-healthy.org/plugins/servlet/mobile?con…/101057620

This Practical Guide is part of Forever Healthy’s “Maximizing Health” initiative that s eeks to holistically review the world’s leading medical knowledge on various health-related topics and turn it into actionable information.

Special thanks are extended to the whole team at Forever Healthy and all of our collaborators for their friendly contributions.

Biological weapons could be built which target individuals in a specific ethnic group based on their DNA, a report by the University of Cambridge has warned.

Researchers from Cambridge’s Centre for the Study of Existential Risk (CSER) said the government was failing to prepare for ‘human-driven catastrophic risks’ that could lead to mass harm and societal collapse.

In recent years advances in science such as genetic engineering, and artificial intelligence (AI) and autonomous vehicles have opened the door to a host of new threats.

Inaugural Academy for Health and Lifespan Research (AHLR) …towards achieving the goal of not just accelerating longevity research, but making sure that its implications are accessible to all…”

The Academy is comprised of an elite group of world-renowned researchers, scientists and clinicians, all united toward making breakthroughs in longevity both accelerated & accessible.

On the Transhumanist Wishlist by Prof George Church, or the genes we have to change to enhance the human body and mind, a new post.

Here are some selections from the so-called Transhumanist Wishlist, drawing upon the philosophical movement of transhumanism that calls for using technology to enhance human physiology and intellect, leading to a transformation of what it means to be human:

A very good article on the life and ideas of life extensionists/immortalists/longevity’s: “… Strole is now 70. He lives in Scottsdale, Arizona, a desert town. In the life-extensionist mode, he avoids dairy and rarely touches bread, though he devours a whole heap of other things. Recently his diet has included pills, branded ”Cognitive”, which he takes twice a day and claims have all sorts of nourishing effects on his brain. (What good is maintaining the body if not the mind?) The pills are part of a self-directed anti-ageing process that requires a lot of swallowing. On some days, Strole takes 70 supplements, including a tablet that ”energises the mitochondria” (mitochondria produce energy) and whose effects resemble ”a shot of coffee, minus the jitters”, as well as vitamins, multi-nutrients and metformin, a diabetes drug that has become so popular among life extensionists that one referred to it as ”the aspirin of anti-ageing”. In the early mornings, when the Arizona air is still brisk, he takes a cold dip in his pool to shock his immune system into better function, and at some point or another he lies face-up on an electromagnetic mat that whirs silently against his body and ”opens up the veins”, and engages in a breathing regime that, he says, ”balances the hormones”.

Some sleep on electromagnetic mats, others pop up to 150 pills a day. But are ‘life extensionists’ any closer to finding the key to longevity? Alex Moshakis meets some of the people determined to become immortal.

Enhancing levels of NAD+ in mitochondria via delivery of various precursor compounds as supplements is growing in popularity as an approach to boost faltering mitochondrial function and thus modestly slow the progression of aging. A human trial demonstrated improved vascular function as a result of nicotinamide riboside supplementation, for example. Researchers here show that increased NAD+ will likely make worse the inflammatory signaling of senescent cells, however. Senescent cells accumulate with age, and are an important cause of the chronic inflammation of aging that drives the progression of many age-related diseases.

The results here suggest that efficient senolytic treatments to selectively destroy senescent cells should proceed any of the current approaches to raising levels of NAD+ in older individuals — and it is an open question as to whether any of the existing available options are efficient enough to make NAD+ enhancement safe in the longer term. Those people self-experimenting with NAD+ precursor supplementation should consider keeping a close eye on markers of inflammation.