Dr Joan Mannick, Head of Research and Development at Life Biosciences, discusses the #geroscience approach in disease treatment and the exciting work being done at Life Biosciences.

#Ageing is the greatest risk factor for almost every chronic disease. Multiple studies have shown that ageing is a modifiable risk factor that can be targeted therapeutically.

In this week’s #HealthyLongevity #webinar session, Dr Joan Mannick, Head of Research and Development at Life Biosciences, discusses the #geroscience approach in disease treatment and the exciting work being done at Life Biosciences.

Register for the upcoming webinar sessions here: https://nus-sg.zoom.us/webinar/register/1816140491076/WN_ym1bHff2RwW1XI9jIwdXCA

#NUSMedicine #webinarseries

Disclaimer: The opinions and advice expressed in this webinar are those of the speakers and do not represent the views and opinions of the organizers and National University of Singapore or any of its subsidiaries or affiliates. The information provided in this webinar is for general information purposes only as part of a general discussion on public health. The information is not intended to be a substitute for professional medical advice, diagnoses or treatment; and cannot be relied on in place of consultation with your licensed healthcare provider.

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This is “Whatabout 1: The future by Aubrey de Grey, gerontologist” by WHAT on Vimeo, the home for high quality videos and the people who love them.

‘The Death of Death’ — David Wood and Jose Cordeiro.

“La mort de la mort — les avancées scientifiques vers l’immortalité” was published on 21st January 2021 and is available in bookshops throughout France, Belgium, Luxembourg, and Switzerland, as well as online — see e.g. https://www.amazon.fr/mort-avanc%C3%A9es-scientifiques-vers-…875422200/

To mark the occasion of the publication, Sergey Young, Founder of the Longevity Vision Fund, asked a number of questions to the book’s co-authors, José Cordeiro and David Wood.

This conversation took place in English — the book itself is in French.

Fair to say that we all assume that aging is inevitable. In reality however, there is no biological law that says we must age. Over the years we’ve seen a variety of theories proposed to explain why we age including the accumulation of damage to our DNA, the damaging effects of chemicals called “free radicals, changes in the function of our mitochondria, and so many others.

Our guest today, Dr. David Sinclair, believes that aging is related to a breakdown of information. Specifically, he describes how, with time, our epigenome accumulates changes that have powerful downstream effects on the way our DNA functions. Reducing these changes to the epigenome is achievable and in fact, even taking it further, his research now reveals that the epigenome can be reprogrammed back to a youthful state.

David A. Sinclair, PhD, AO is Professor of Genetics at Harvard Medical School, and is the author of Lifespan — Why We Age and Why We Don’t Have To. He is the Founding Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard. One of the leading innovators of his generation, he is listed by TIME magazine as one of the “100 most influential people in the world” (2014) and top 50 most important people in healthcare (2018). He is a board member of the American Federation for Aging Research, a Founding Editor of the journal Aging, and has received more than 35 awards for his research on resveratrol, NAD, and reprogramming to reverse aging, which have been widely hailed as major scientific breakthroughs and are topics we discuss in our time together.

In 2018, Dr. Sinclair became an Officer of the Order of Australia, the equivalent of a knighthood, for his work on national security matters and human longevity. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others.

In closing, I really need to say that Lifespan (https://amzn.to/3sSoCNS) ranks as one of the most influential books I have ever read. Please enjoy today’s interview.

To stay current on Dr. Sinclair, follow him on Twitter (https://twitter.com/davidasinclair) and Instagram (https://www.instagram.com/davidsinclairphd/)

Oneskin — the first skin cream that destroys senescent cells:

Longevity, Health, Long Lifespans, and Halthspans, Psychology, Spirituality — I and Carolina Reis Oliveira talk about all these things in relation to the skin. Find out how you can have very healthy skin with OneSkin!

Visit OneSkin’s website — https://www.oneskin.co/

0:00 — Logo & Title.
0:17 — H! & Intro.
1:40 — Presentation.
2:20 — Presentation | Skin Health — Longevity.
3:57 — Presentation | The Root Cause of Aging.
4:46 — Presentation | Senescent Cells.
5:49 — Presentation | Current solutions.
6:32 — Presentation | OneSkin Approach.
7:47 — Presentation | Let’s Dive Deeper into the Science.
9:51 — Presentation | Replicating Skin Aging.
11:42 — Presentation | Developing an Algorithm to Measure Skin Aging.
12:58 — Presentation | A Drug Discovery Process.
14:23 — Presentation | Senotherapeutic Compounds.
15:00 — Presentation | OS1
15:42 — Presentation | OS1 & UVB Radiation.
17:13 — Presentation | OS1 — Validate effects in 3D models.
19:33 — Presentation | OS1 — Treatment in Skin Biopsies.
20:55 — Presentation | OS1 — Safety.
21:43 — Presentation | OS1 — Clinical Study Results.
23:18 — Presentation | OS1 — Applications Beyond Skin.
26:14 — Presentation | Team.
28:07 — Q&A + the Conversation.
28:25 — Futuristic Psychology & Spirituality.
31:34 — Myths Regarding Immortality.
34:20 — The Collective Rejuvenation.
37:10 — Biologic Hygiene.
41:56 — Cellular Senescence.
46:00 — The Molecular Clock.
48:04 — Morphogenesis of a Scar.
51:15 — Differences Between Skin Types on a Body.
52:35 — Skin Types Regarding Different Races.
54:44 — Skin Conditions.
56:03 — Closing & Ending

No that’s not clickbait.
Being able to stop and reverse aging is probably something every single person has yearned for at some point in their life. Now researchers are finally seeing successful implementations of methods for reversing aging in Animal cells. This creates the potential for countless benefits for humans. These range from simply preventing age related illness all the way to allowing women the opportunity to have kids at any point in their life when they are ready. We are living in very exciting scientific times.

References:

Reprogramming to recover youthful epigenetic information and restore vision — https://doi.org/10.1038/s41586-020-2975-4

NAD+ Repletion Rescues Female Fertility during Reproductive Aging — https://doi.org/10.1016/j.celrep.2020.01.

Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16 — https://doi.org/10.1007/s10522-009-9225-3

Age-related NAD+ decline — https://doi.org/10.1016/j.exger.2020.

Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice — https://dx.doi.org/10.1016%2Fj.cmet.2016.09.

A breakthrough skin-gel is showing promising signs in Australian trials, with the ability to halt chronic pain in its tracks, halve healing time and even turn back the clock on ageing skin.

The gel, which is known as RM191A, is believed to be a new class of anti-inflammatory.

It’s a copper-based compound which is applied directly to the skin as a topical.

Welcome to the Siim Land Podcast I’m your host Siim Land and our guest today is Liz Parish. Liz is the founder and CEO of BioViva. Which is a company committed to extending human lifespan using techniques such as gene and cell technologies. Liz Parrish became the first person worldwide to take dual gene therapies for treating aging.

Summary: Scientists have long marveled at the rejuvenating effects of heterochronic parabiosis. When you mix the blood of a young mouse and an old mouse by joining their circulatory systems, the older animal recovers some features of youth, while the young animal becomes functionally older. While many have assumed that these effects were driven by the infusion of pro-youth factors from the young parabiont into the older one, an alternative “Dilution Solution” hypothesis is possible: that the young blood is instead diluting pro-aging factors from the old animal’s blood, as well as allowing the young animal’s livers and kidneys to filter out metabolic toxins through the young animals’ livers and kidneys.

In heterochronic parabiosis, joining the circulatory systems of young and old mice causes the older animal to recover some features of youth. The effect has been widely assumed to be driven by pro-youth factors in younger blood, but an alternative hypothesis is possible: that the procedure is instead diluting pro-aging factors in the older partner.

Gene therapies are opening up possibilities that were once reserved for science fiction.

At Harvard University, Professor of Genetics David Sinclair says he believes it’s possible to unlock the fountain of youth, and gene therapy is the key.

Sinclair spent two years trying to correct the vision of a mouse using gene therapy, and finally succeeded in doing it.

Although these discoveries are encouraging, Sinclair cautions that people set their expectations realistically.

“Many people are eager to use the research for their own health benefit,” he said. “But I’m hoping that the public will realize that it does take a long time and we can’t just jump from a mouse to a human tomorrow.”

Aging researcher Dr. Nir Barzilai is studying clinical trials that use the diabetes drug metformin to directly target aging.