A preventative anti-aging therapy seems like wishful thinking.

Yet a new study led by Dr. Corina Amor Vegas at Cold Spring Harbor Laboratory describes a treatment that brings the dream to life—at least for mice. Given a single injection in young adulthood, they aged more slowly compared to their peers.

By the equivalent of roughly 65 years of age in humans, the mice were slimmer, could better regulate blood sugar and insulin levels, and had lower inflammation and a more youthful metabolic profile. They even kept up their love for running, whereas untreated seniors turned into couch potatoes.

Scientists have made progress in understanding how the brain processes time, potentially rewriting the narrative on neural flexibility and cognitive function.

The research, led by Professor Arkarup Banerjee in the Cold Spring Harbor Laboratory, focused on the vocalizations of Alston’s singing mouse from Costa Rica, offers profound insights into how our brains may bend the perception of time to adapt to varying circumstances.

This phenomenon could have far-reaching implications across numerous fields including technology, education, and therapy.

It started as a big old ball of dust, so how did it end up like a giant pancake? Our resident physicist tells the true story using fake forces.

Plutonium-pit secrets, growing up in parallel universes, the strange aftermath of a fictional wildfire, and more books out now.

Deloitte’s Global Generative AI Innovation Leader Nitin Mittal and Tomorrow CEO Mike Walsh explore the Fifth Industrial Revolution in which the catalyst for societal transformation is the augmentation and expansion of human intelligence.

Given the recency of the Fourth Industrial Revolution, it might be a surprise that we are on the verge of an entirely new one. Rapid progress in computation, connectivity, and artificial intelligence (AI)—accelerated by the COVID-19 pandemic—has brought forward the timeline for transformation. While prior industrial revolutions were premised on gains in operational efficiency, the next revolution will be powered by minds, not just machines—where the catalyst for societal transformation is the augmentation and expansion of human intelligence.

Bacteria choose to swarm based on what happened to their great-grandmothers.

With anaesthetics and brain organoids, we are finally testing whether quantum effects can explain consciousness. We may have misunderstood this long-derided idea, says George Musser.

This story is part of a series on the current progression in Regenerative Medicine. This piece discusses advances in Alzheimer’s therapy.

In 1999, I defined regenerative medicine as the collection of interventions that restore normal function to tissues and organs damaged by disease, injured by trauma, or worn by time. I include a full spectrum of chemical, gene, and protein-based medicines, cell-based therapies, and biomechanical interventions that achieve that goal.

An emerging combination of focused ultrasound therapy with a recently approved medication could be our best treatment for Alzheimer’s disease to date. In the New England Journal of Medicine, Dr. Ali Rezai and colleagues from West Virginia University describe an approach to reduce cerebral amyloid-beta load, a biomarker for neurodegeneration, in patients with Alzheimer’s. While in its preliminary stages, the combination treatment can potentially help thousands, if not millions, suffering from the disease in the near future.

A tragedy in the making.

How Lake Kivu became a ticking time bomb

Lake Kivu sits along the East African Rift Valley, dotted with hot springs that feed carbon dioxide and methane into its depths.

“Kivu has a complicated vertical structure,” Sergei Katsev, a limnologist at University of Minnesota Duluth, explains. While “the top [200 feet] or so mix regularly,” the rest of the lake remains stratified. Nearly 72 cubic miles of dissolved carbon dioxide and 14 cubic miles of methane, laced with toxic hydrogen sulfide, remain trapped in the bottom of the lake. They sit beneath a “main density gradient” at 850 feet below the surface.

The year 2023 saw the “enshittification” of platforms from Facebook to Google Search. A new exit strategy means platforms will have to play nicely with your data, even if you leave for a rival.